Alexander Yakunin

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Alexei SavchenkoUniversity of CalgaryVerified email at ucalgary.ca
Anna KhusnutdinovaBangor UniversityVerified email at bangor.ac.uk
Andrzej JoachimiakArgonne Nat. Lab., Distinguished Fellow, Prof. Univ. of Chicago, Adj. Prof. Northwestern Univ.Verified email at anl.gov
Radhakrishnan MahadevanProfessor of Chemical Engineering & Applied Chemistry, University of TorontoVerified email at utoronto.ca
Eugene KooninSenior Investigator, NCBI, NIHVerified email at ncbi.nlm.nih.gov
Cheryl ArrowsmithSenior Scientist, Princess Margaret Cancer Centre & Professor of Medical Biophysics, University of TorontoVerified email at uhnres.utoronto.ca
Patrick C. HallenbeckMicro&Immuno University of MontrealVerified email at umontreal.ca
Elizabeth A. EdwardsChemical Engineering and Applied Chemistry, University of TorontoVerified email at utoronto.ca
Peter N GolyshinProfessor in Environmental Genomics, School of Natural Sciences, Bangor UniversityVerified email at bangor.ac.uk
Kira MakarovaNCBI, NIHVerified email at ncbi.nlm.nih.gov
Claudio GonzalezProfessor, Microbiology and Cell Science, IFAS, University of FloridaVerified email at ufl.edu
Dr Olga V GolyshinaReader, School of Natural Sciences, Bangor UniversityVerified email at bangor.ac.uk
Michail YakimovHead of Extreme Microbiology, Biotechnology and Astrobiology Group, ISP-CNRVerified email at virgilio.it
Sylvain MoineauUniversité LavalVerified email at bcm.ulaval.ca
Daniel HaftStaff Scientist, National Center for Biotechnology Information, NIHVerified email at nih.gov
John van der OostMicrobiology, Wageningen UniversityVerified email at wur.nl
Rodolphe BarrangouNorth Carolina State UniversityVerified email at ncsu.edu
Stan J.J. BrounsProfessor of Molecular Microbiology, Delft University of TechnologyVerified email at tudelft.nl
Philippe HORVATHIFFVerified email at iff.com
Dr Tatyana ChernikovaResearcher, School of Natural Sciences, Bangor UniversityVerified email at bangor.ac.uk

Alexander Yakunin

University of Toronto (Canada), Bangor University (UK)

Verified email at bangor.ac.uk

enzymes


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Evolution and classification of the CRISPR–Cas systems KS Makarova, DH Haft, R Barrangou, SJJ Brouns, E Charpentier, ... Nature Reviews Microbiology 9 (6), 467-477, 2011	3450	2011
An updated evolutionary classification of CRISPR–Cas systems KS Makarova, YI Wolf, OS Alkhnbashi, F Costa, SA Shah, SJ Saunders, ... Nature reviews microbiology 13 (11), 722-736, 2015	2984	2015
Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants KS Makarova, YI Wolf, J Iranzo, SA Shmakov, OS Alkhnbashi, SJJ Brouns, ... Nature Reviews Microbiology 18 (2), 67-83, 2020	1996	2020
Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family E Kuznetsova, M Proudfoot, CF Gonzalez, G Brown, MV Omelchenko, ... Journal of Biological Chemistry 281 (47), 36149-36161, 2006	369	2006
A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair M Babu, N Beloglazova, R Flick, C Graham, T Skarina, B Nocek, ... Molecular microbiology 79 (2), 484-502, 2011	359	2011
In situ proteolysis for protein crystallization and structure determination A Dong, X Xu, AM Edwards Nature methods 4 (12), 1019-1021, 2007	292	2007
Heavy metal removal by bioaccumulation using genetically engineered microorganisms P Diep, R Mahadevan, AF Yakunin Frontiers in bioengineering and biotechnology 6, 157, 2018	281	2018
A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats N Beloglazova, G Brown, MD Zimmerman, M Proudfoot, KS Makarova, ... Journal of Biological Chemistry 283 (29), 20361-20371, 2008	270	2008
Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction N Beloglazova, R Flick, A Tchigvintsev, G Brown, A Popovic, B Nocek, ... Journal of Biological Chemistry 288 (12), 8101-8110, 2013	265	2013
Enzyme genomics: Application of general enzymatic screens to discover new enzymes E Kuznetsova, M Proudfoot, SA Sanders, J Reinking, A Savchenko, ... FEMS microbiology reviews 29 (2), 263-279, 2005	193	2005
Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference N Beloglazova, P Petit, R Flick, G Brown, A Savchenko, AF Yakunin The EMBO journal 30 (22), 4616-4627, 2011	170	2011
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia C Schneider, T Oellerich, HM Baldauf, SM Schwarz, D Thomas, R Flick, ... Nature medicine 23 (2), 250-255, 2017	165	2017
Structural insight into the mechanism of c-di-GMP hydrolysis by EAL domain phosphodiesterases A Tchigvintsev, X Xu, A Singer, C Chang, G Brown, M Proudfoot, H Cui, ... Journal of molecular biology 402 (3), 524-538, 2010	164	2010
Molecular basis of formaldehyde detoxification: characterization of two S-formylglutathione hydrolases from Escherichia coli, FrmB and YeiG CF Gonzalez, M Proudfoot, G Brown, Y Korniyenko, H Mori, ... Journal of Biological Chemistry 281 (20), 14514-14522, 2006	158	2006
Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria B Nocek, S Kochinyan, M Proudfoot, G Brown, E Evdokimova, J Osipiuk, ... Proceedings of the National Academy of Sciences 105 (46), 17730-17735, 2008	154	2008
Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica M Kube, TN Chernikova, Y Al-Ramahi, A Beloqui, N Lopez-Cortez, ... Nature communications 4 (1), 2156, 2013	150	2013
Riboneogenesis in yeast MF Clasquin, E Melamud, A Singer, JR Gooding, X Xu, A Dong, H Cui, ... Cell 145 (6), 969-980, 2011	146	2011
Biochemical and structural insights into enzymatic depolymerization of polylactic acid and other polyesters by microbial carboxylesterases M Hajighasemi, BP Nocek, A Tchigvintsev, G Brown, R Flick, X Xu, H Cui, ... Biomacromolecules 17 (6), 2027-2039, 2016	145	2016
Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli R Sanishvili, AF Yakunin, RA Laskowski, T Skarina, E Evdokimova, ... Journal of Biological Chemistry 278 (28), 26039-26045, 2003	144	2003
Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis G Brown, A Singer, M Proudfoot, T Skarina, Y Kim, C Chang, ... Biochemistry 47 (21), 5724-5735, 2008	131	2008

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