Dustin J Little
Dustin J Little
Assistant Professor, Ryerson University
Verified email at - Homepage
Cited by
Cited by
Identification of poly-N-acetylglucosamine as a major polysaccharide component of the Bacillus subtilis biofilm matrix
D Roux, C Cywes-Bentley, YF Zhang, S Pons, M Konkol, DB Kearns, ...
Journal of Biological Chemistry 290 (31), 19261-19272, 2015
Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus*♦
NC Bamford, BD Snarr, FN Gravelat, DJ Little, MJ Lee, CA Zacharias, ...
Journal of Biological Chemistry 290 (46), 27438-27450, 2015
The structure-and metal-dependent activity of Escherichia coli PgaB provides insight into the partial de-N-acetylation of poly-β-1, 6-N-acetyl-D-glucosamine
DJ Little, J Poloczek, JC Whitney, H Robinson, M Nitz, PL Howell
Journal of Biological Chemistry 287 (37), 31126-31137, 2012
Characterization of the Pseudomonas aeruginosa glycoside hydrolase PslG reveals that its levels are critical for Psl polysaccharide biosynthesis and biofilm formation
P Baker, GB Whitfield, PJ Hill, DJ Little, MJ Pestrak, H Robinson, ...
Journal of Biological Chemistry 290 (47), 28374-28387, 2015
P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation
P Baker, T Ricer, PJ Moynihan, EN Kitova, MTC Walvoort, DJ Little, ...
PLoS pathogens 10 (8), e1004334, 2014
Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6-N-acetyl-d-glucosamine
DJ Little, G Li, C Ing, BR DiFrancesco, NC Bamford, H Robinson, M Nitz, ...
Proceedings of the National Academy of Sciences 111 (30), 11013-11018, 2014
PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β (1, 6)-N-acetylglucosamine and can disrupt bacterial biofilms
DJ Little, R Pfoh, F Le Mauff, NC Bamford, C Notte, P Baker, M Guragain, ...
PLoS pathogens 14 (4), e1006998, 2018
PilN binding modulates the structure and binding partners of the Pseudomonas aeruginosa type IVa pilus protein PilM
M McCallum, S Tammam, DJ Little, H Robinson, J Koo, M Shah, ...
Journal of biological Chemistry 291 (21), 11003-11015, 2016
Functional Characterization of Staphylococcus epidermidis IcaB, a De-N-acetylase Important for Biofilm Formation
V Pokrovskaya, J Poloczek, DJ Little, H Griffiths, PL Howell, M Nitz
Biochemistry 52 (32), 5463-5471, 2013
PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides
D Sychantha, DJ Little, RN Chapman, GJ Boons, H Robinson, PL Howell, ...
Nature chemical biology 14 (1), 79-85, 2018
The protein BpsB is a poly-β-1, 6-N-acetyl-D-glucosamine deacetylase required for biofilm formation in Bordetella bronchiseptica
DJ Little, S Milek, NC Bamford, T Ganguly, BR DiFrancesco, M Nitz, ...
Journal of Biological Chemistry 290 (37), 22827-22840, 2015
In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA)
D Sychantha, CS Jones, DJ Little, PJ Moynihan, H Robinson, NF Galley, ...
PLoS pathogens 13 (10), e1006667, 2017
Structural basis for the de-N-acetylation of poly-β-1, 6-N-acetyl-D-glucosamine in Gram-positive bacteria
DJ Little, NC Bamford, V Pokrovskaya, H Robinson, M Nitz, PL Howell
Journal of Biological Chemistry 289 (52), 35907-35917, 2014
Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation
A Chibba, J Poloczek, DJ Little, PL Howell, M Nitz
Organic & biomolecular chemistry 10 (35), 7103-7107, 2012
Regulatory evolution drives evasion of host inflammasomes by Salmonella Typhimurium
B Ilyas, DT Mulder, DJ Little, W Elhenawy, MM Banda, D Pérez-Morales, ...
Cell Reports 25 (4), 825-832. e5, 2018
Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli
D Valleau, DJ Little, D Borek, T Skarina, AT Quaile, R Di Leo, S Houliston, ...
Proceedings of the National Academy of Sciences 115 (40), 10004-10009, 2018
Combining in situ proteolysis and mass spectrometry to crystallize Escherichia coli PgaB
DJ Little, JC Whitney, H Robinson, P Yip, M Nitz, PL Howell
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2012
Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli
DJ Little, BK Coombes
PLoS Pathogens 14 (8), e1007224, 2018
Direct Staudinger–Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De‐N‐acetylases
R Ariyakumaran, V Pokrovskaya, DJ Little, PL Howell, M Nitz
ChemBioChem 16 (9), 1350-1356, 2015
The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing
R Pfoh, AS Subramanian, J Huang, DJ Little, A Forman, BR DiFrancesco, ...
PLoS Pathogens 18 (8), e1010750, 2022
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