| Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein AP Wong, CE Bear, S Chin, P Pasceri, TO Thompson, LJ Huan, F Ratjen, ... Nature biotechnology 30 (9), 876-882, 2012 | 462 | 2012 |
| Directed differentiation of cholangiocytes from human pluripotent stem cells M Ogawa, S Ogawa, CE Bear, S Ahmadi, S Chin, B Li, M Grompe, ... Nature biotechnology 33 (8), 853-861, 2015 | 305 | 2015 |
| Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans S Shojaie, L Ermini, C Ackerley, J Wang, S Chin, B Yeganeh, M Bilodeau, ... Stem cell reports 4 (3), 419-430, 2015 | 120 | 2015 |
| Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells AP Wong, S Chin, S Xia, J Garner, CE Bear, J Rossant nature protocols 10 (3), 363-381, 2015 | 78 | 2015 |
| Functional rescue of F508del-CFTR using small molecule correctors S Molinski, PDW Eckford, S Pasyk, S Ahmadi, S Chin, CE Bear Frontiers in pharmacology 3, 160, 2012 | 54 | 2012 |
| Lipophilicity of the cystic fibrosis drug, ivacaftor (VX-770), and its destabilizing effect on the major CF-causing mutation: F508del S Chin, M Hung, A Won, YS Wu, S Ahmadi, D Yang, S Elmallah, K Toutah, ... Molecular pharmacology 94 (2), 917-925, 2018 | 39 | 2018 |
| The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation S Pasyk, S Molinski, S Ahmadi, M Ramjeesingh, LJ Huan, S Chin, K Du, ... Proteomics 15 (2-3), 447-461, 2015 | 31 | 2015 |
| Cholesterol interaction directly enhances intrinsic activity of the cystic fibrosis transmembrane conductance regulator (CFTR) S Chin, M Ramjeesingh, M Hung, J Ereño-Oreba, H Cui, O Laselva, ... Cells 8 (8), 804, 2019 | 25 | 2019 |
| Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants. CEB S Chin, M Hung Cell Mol Life Sci 74 (1), 57-66, 2017 | 25 | 2017 |
| Generation of functional ciliated cholangiocytes from human pluripotent stem cells M Ogawa, JX Jiang, S Xia, D Yang, A Ding, O Laselva, M Hernandez, ... Nature communications 12 (1), 6504, 2021 | 24 | 2021 |
| Structural effects of extracellular loop mutations in CFTR helical hairpins YH Chang, TA Stone, S Chin, M Glibowicka, CE Bear, CM Deber Biochimica et Biophysica Acta (BBA)-Biomembranes 1860 (5), 1092-1098, 2018 | 9 | 2018 |
| Attenuation of phosphorylation-dependent activation of cystic fibrosis transmembrane conductance regulator (CFTR) by disease-causing mutations at the transmission interface S Chin, D Yang, AJ Miles, PDW Eckford, S Molinski, BA Wallace, CE Bear Journal of Biological Chemistry 292 (5), 1988-1999, 2017 | 8 | 2017 |
| Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR) S Chin, M Ramjeesingh, M Hung, J Ereño-Oreba, C Ing, ZW Zeng, H Cui, ... BioRxiv, 495010, 2018 | 3 | 2018 |
| Regulation of CFTR function and stability by phosphorylation and its membrane environment S Chin University of Toronto (Canada), 2019 | | 2019 |
| MODULATION OF CFTR BY ITS PHOSPHORYLATION AND INTERACTION WITH SMALL MOLECULES CE Bear, M Hung, S Chin, O Laselva, S Pasyk, S Ahmadi, R Viirre, ... PEDIATRIC PULMONOLOGY. SUPPLEMENT 53, 78-79, 2018 | | 2018 |
| COUPLING BETWEEN CYTOSOLIC AND MEMBRANE DOMAINS MODIFIES PKA-DEPENDENT CFTR CHANNEL ACTIVATION S Chin, D Yang, S Molinski, M Ramjeesingh, P Eckford, CE Bear PEDIATRIC PULMONOLOGY 51, 196-196, 2016 | | 2016 |
| Phosphorylation Modifies Coupling of the Membrane Domains and NBD1 of Full Length CFTR S Chin, M Ramjeesingh, P Eckford, CE Bear Biophysical Journal 110 (3), 546a, 2016 | | 2016 |
| Investigating the Effect of PKA Phosphorylation on Intramolecular Interactions in Purified Full Length Wildtype CFTR S Chin, M Ramjeesingh, P Eckford, C Bear Biophysical Journal 108 (2), 382a-383a, 2015 | | 2015 |
| TRIMETHYLANGELICIN (TMA) BINDS DIRECTLY TO PURIFIED WILD-TYPE CFTR O Laselva, S Chin, S Molinski, J Ereno, J Julien, V Casavola, CE Bear PEDIATRIC PULMONOLOGY. SUPPLEMENT 50, 204-204, 2015 | | 2015 |
| INVESTIGATING THE EFFECT OF PHOSPHORYLATION ON THE THERMODYNAMICS AND ENERGETICS OF UNFOLDING OF FULL LENGTH CFTR S Chin, M Ramjeesingh, PD Eckford, CE Bear PEDIATRIC PULMONOLOGY 48, 229-229, 2013 | | 2013 |
