| MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ... Nature 508 (7495), 215-221, 2014 | 535 | 2014 |
| Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation T Visnes, A Cázares-Körner, W Hao, O Wallner, G Masuyer, O Loseva, ... Science 362 (6416), 834-839, 2018 | 192 | 2018 |
| Cancer-specific synthetic lethality between ATR and CHK1 kinase activities K Sanjiv, A Hagenkort, JM Calderón-Montaño, T Koolmeister, PM Reaper, ... Cell reports 14 (2), 298-309, 2016 | 150 | 2016 |
| Validation and development of MTH1 inhibitors for treatment of cancer UW Berglund, K Sanjiv, H Gad, C Kalderen, T Koolmeister, T Pham, ... Annals of oncology 27 (12), 2275-2283, 2016 | 139 | 2016 |
| Rational design and validation of a Tip60 histone acetyltransferase inhibitor C Gao, E Bourke, M Scobie, MA Famme, T Koolmeister, T Helleday, ... Scientific reports 4 (1), 5372, 2014 | 125 | 2014 |
| Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells BDG Page, NCK Valerie, RHG Wright, O Wallner, R Isaksson, M Carter, ... Nature communications 9 (1), 250, 2018 | 72 | 2018 |
| Pinacolyl boronic esters as components in the Petasis reaction T Koolmeister, M Södergren, M Scobie Tetrahedron letters 43 (34), 5965-5968, 2002 | 68 | 2002 |
| The first example of chiral induction using homochiral boronic esters in the Petasis reaction T Koolmeister, M Södergren, M Scobie Tetrahedron letters 43 (34), 5969-5970, 2002 | 64 | 2002 |
| A new concise synthesis of 2, 3-dihydroquinazolin-4 (1 H)-one derivatives M Desroses, M Scobie, T Helleday New Journal of Chemistry 37 (11), 3595-3597, 2013 | 47 | 2013 |
| The synthesis of some head to head linked DNA minor groove binders AI Khalaf, AR Pitt, M Scobie, CJ Suckling, J Urwin, RD Waigh, ... Tetrahedron 56 (29), 5225-5239, 2000 | 46 | 2000 |
| Discovery of the first potent and selective inhibitors of human dCTP pyrophosphatase 1 S Llona-Minguez, A Hoglund, SA Jacques, L Johansson, ... Journal of medicinal chemistry 59 (3), 1140-1148, 2016 | 45 | 2016 |
| Tumor-targeted boranes. 4. Synthesis of nitroimidazole-carboranes with polyether-isoxazole links M Scobie, MD Threadgill The Journal of Organic Chemistry 59 (23), 7008-7013, 1994 | 45 | 1994 |
| Targeting OGG1 arrests cancer cell proliferation by inducing replication stress T Visnes, C Benítez-Buelga, A Cázares-Körner, K Sanjiv, BMF Hanna, ... Nucleic acids research 48 (21), 12234-12251, 2020 | 41 | 2020 |
| dUTPase inhibition augments replication defects of 5-Fluorouracil A Hagenkort, CBJ Paulin, M Desroses, A Sarno, E Wiita, O Mortusewicz, ... Oncotarget 8 (14), 23713, 2017 | 41 | 2017 |
| Gold-Catalyzed Addition of N-Hydroxy Heterocycles to Alkynes and Subsequent 3,3-Sigmatropic Rearrangement M Kumar, M Scobie, MS Mashuta, GB Hammond, B Xu Organic letters 15 (4), 724-727, 2013 | 41 | 2013 |
| A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma BO Einarsdottir, J Karlsson, EMV Söderberg, MF Lindberg, ... Cell Death & Disease 9 (8), 810, 2018 | 40 | 2018 |
| Fragment-based discovery and optimization of enzyme inhibitors by docking of commercial chemical space A Rudling, R Gustafsson, I Almlof, E Homan, M Scobie, ... Journal of Medicinal Chemistry 60 (19), 8160-8169, 2017 | 39 | 2017 |
| DNA binding, solubility, and partitioning characteristics of extended lexitropsins RV Fishleigh, KR Fox, AI Khalaf, AR Pitt, M Scobie, CJ Suckling, J Urwin, ... Journal of medicinal chemistry 43 (17), 3257-3266, 2000 | 32 | 2000 |
| Parallel synthesis of unsymmetrically substituted tetraphenyl porphyrins on Wang resin B Shi, M Scobie, RW Boyle Tetrahedron letters 44 (27), 5083-5086, 2003 | 31 | 2003 |
| Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress N Bonagas, NMS Gustafsson, M Henriksson, P Marttila, R Gustafsson, ... Nature cancer 3 (2), 156-172, 2022 | 29 | 2022 |
