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Roberto Orrù
Roberto Orrù
Bayer AG
Verified email at bayer.com
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Cited by
Year
ThermoFAD, a Thermofluor®‐adapted flavin ad hoc detection system for protein folding and ligand binding
F Forneris, R Orru, D Bonivento, LR Chiarelli, A Mattevi
The FEBS journal 276 (10), 2833-2840, 2009
2252009
Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase
A Alfieri, E Malito, R Orru, MW Fraaije, A Mattevi
Proceedings of the National Academy of Sciences 105 (18), 6572-6577, 2008
1792008
Snapshots of enzymatic Baeyer-Villiger catalysis: oxygen activation and intermediate stabilization
R Orru, HM Dudek, C Martinoli, DET Pazmiño, A Royant, M Weik, ...
Journal of Biological Chemistry 286 (33), 29284-29291, 2011
1522011
Joint functions of protein residues and NADP (H) in oxygen activation by flavin-containing monooxygenase
R Orru, DET Pazmino, MW Fraaije, A Mattevi
Journal of biological chemistry 285 (45), 35021-35028, 2010
592010
Crystal structure of 3-hydroxybenzoate 6-hydroxylase uncovers lipid-assisted flavoprotein strategy for regioselective aromatic hydroxylation
S Montersino, R Orru, A Barendregt, AH Westphal, E van Duijn, A Mattevi, ...
Journal of Biological Chemistry 288 (36), 26235-26245, 2013
542013
Do MAO A and MAO B utilize the same mechanism for the C–H bond cleavage step in catalysis? Evidence suggesting differing mechanisms
R Orru, M Aldeco, DE Edmondson
Journal of Neural Transmission 120, 847-851, 2013
422013
Optimization of d‐amino acid oxidase for low substrate concentrations – towards a cancer enzyme therapy
E Rosini, L Pollegioni, S Ghisla, R Orru, G Molla
The FEBS Journal 276 (17), 4921-4932, 2009
422009
RApid Parallel Protein EvaluatoR (RAPPER), from gene to enzyme function in one day
LT Quertinmont, R Orru, S Lutz
Chemical communications 51 (1), 122-124, 2015
262015
IM30 IDPs form a membrane-protective carpet upon super-complex disassembly
B Junglas, R Orru, A Axt, C Siebenaller, W Steinchen, J Heidrich, ...
Communications biology 3 (1), 595, 2020
182020
Beyond the protein matrix: Probing cofactor variants in a Baeyer–Villiger oxygenation reaction
C Martinoli, HM Dudek, R Orru, DE Edmondson, MW Fraaije, A Mattevi
ACS catalysis 3 (12), 3058-3062, 2013
162013
3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1 Contains a Phosphatidylinositol Cofactor
S Montersino, E Te Poele, R Orru, AH Westphal, A Barendregt, AJR Heck, ...
Frontiers in Microbiology 8, 1110, 2017
132017
Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein
A Garg, R Orru, W Ye, U Distler, JE Chojnacki, M Köhn, S Tenzer, ...
Journal of Biological Chemistry 294 (45), 16604-16619, 2019
102019
Structural basis of regioselective hydroxylation in 3 hydroxybenzoate hydroxylases
S Montersino, R Orru, A Mattevi, WJH van Berkel
Flavins and Flavoproteins 2011: Proceedings 17th International Symposium on …, 2013
12013
Mirroring human monoamine oxidases A and B: Similar structures with opposite mechanisms of C‐H bond cleavage
R Orru, M Aldeco, DE Edmondson
The FASEB Journal 27, 789.2-789.2, 2013
2013
Baeyer-Villiger Monooxygenase: Oxygen Activation and Substrate Selectivity
R Orrù, HM Dudek, C Martinoli, P Stępniak, LS Wyrwicz, DET Pazmiño, ...
FLAVINS and FLAVOPROTEINS 2011, 313, 2013
2013
Insight into the regioselectivity of flavin-dependent aromatic hydroxylation
S Montersino, AH Westphal, R Orru, A Bonvin, A Mattevi, WJH van Berkel
2011
Structure and function of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1.
S Montersino, R Orru, A Mattevi, WJH van Berkel
17th International Symposium on Flavins and Flavoproteins, Berkeley …, 2011
2011
Investigating the oxygen reactivity in enzymes
A Mattevi, R Orrù, R Baron, P Chaiyen, MW Fraaije
Foundations of Crystallography 66 (a1), 28-28, 2010
2010
Production of evolved D-amino acid oxidases for a cancer enzyme therapy
E Rosini, G Molla, R Orru, M Pilone, L Pollegioni
2008
Modulation of the oxygen affinity of D-amino acid oxidase: production of evolved variants for a cancer enzyme therapy
L Pollegioni, E Rosini, M Pilone, R Orru, G Molla
Flavins and Flavoproteins, 497-502, 2008
2008
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