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Prakash Kharel
Prakash Kharel
Investigator and Instructor in Medicine at Brigham and Women's Hospital/ Harvard Medical School
Verified email at bwh.harvard.edu
Title
Cited by
Cited by
Year
Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back
P Kharel, G Becker, V Tsvetkov, P Ivanov
Nucleic acids research 48 (22), 12534-12555, 2020
1102020
The role of RNA G‐quadruplexes in human diseases and therapeutic strategies
P Kharel, S Balaratnam, N Beals, S Basu
Wiley Interdisciplinary Reviews: RNA 11 (1), e1568, 2020
872020
eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function
SM Lyons, P Kharel, Y Akiyama, S Ojha, D Dave, V Tsvetkov, W Merrick, ...
Nucleic acids research 48 (11), 6223-6233, 2020
652020
Tumor interferon signaling is regulated by a lncRNA INCR1 transcribed from the PD-L1 locus
M Mineo, SM Lyons, M Zdioruk, N von Spreckelsen, R Ferrer-Luna, H Ito, ...
Molecular cell 78 (6), 1207-1223. e8, 2020
512020
Isolation and initial structure-functional characterization of endogenous tRNA-derived stress-induced RNAs
Y Akiyama, P Kharel, T Abe, P Anderson, P Ivanov
RNA biology 17 (8), 1116-1124, 2020
492020
Stress promotes RNA G-quadruplex folding in human cells
P Kharel, M Fay, EV Manasova, PJ Anderson, AV Kurkin, JU Guo, ...
Nature Communications 14 (1), 205, 2023
352023
Targeting of G-quadruplex harboring pre-miRNA 92b by LNA rescues PTEN expression in NSCL cancer cells
G Mirihana Arachchilage, P Kharel, J Reid, S Basu
ACS chemical biology 13 (4), 909-914, 2018
332018
Evidence of extensive RNA oxidation in normal appearing cortex of multiple sclerosis brain
P Kharel, J McDonough, S Basu
Neurochemistry international 92, 43-48, 2016
142016
Isolation, identification and antimicrobial activity of a Withanolide [WS-1] from the roots of Withania somnifera
P Kharel, MD Manandhar, SK Kalauni, S Awale, J Baral
Nepal Journal of Science and Technology 12, 179-186, 2011
132011
Volume measurements and fluorescent staining indicate an increase in permeability for organic cation transporter substrates during apoptosis
BA Gibbons, P Kharel, LC Robinson, RA Synowicki, MA Model
Experimental cell research 344 (1), 112-119, 2016
122016
Mono-and bilayer smectic liquid crystal ordering in dense solutions of “gapped” DNA duplexes
P Gyawali, R Saha, GP Smith, M Salamonczyk, P Kharel, S Basu, R Li, ...
Proceedings of the National Academy of Sciences 118 (12), e2019996118, 2021
112021
Engineered domain swapping indicates context dependent functional role of RNA G-quadruplexes
D Bhattacharyya, MJ Morris, P Kharel, GM Arachchilage, KM Fedeli, ...
Biochimie 137, 147-150, 2017
92017
NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis
P Kharel, NK Singhal, T Mahendran, N West, B Croos, J Rana, L Smith, ...
Cell Chemical Biology 30 (3), 308-320. e5, 2023
42023
Rationally designed DNA therapeutics can modulate human tyrosine hydroxylase expression by controlling specific G-quadruplex formation in its promoter
N Beals, M M Farhath, P Kharel, B Croos, T Mahendran, J Johnson, ...
Elsevier Ltd., 2021
32021
RNA G-quadruplexes and stress: emerging mechanisms and functions
P Kharel, P Ivanov
Trends in Cell Biology, 2024
22024
Rationally designed DNA therapeutics can modulate human TH expression by controlling specific GQ formation in its promoter
N Beals, MM Farhath, P Kharel, B Croos, T Mahendran, J Johnson, ...
Molecular Therapy 30 (2), 831-844, 2022
22022
Structure and Functions of RNA G-quadruplexes
P Kharel, P Ivanov
RNA Structure and Function, 183-203, 2023
12023
HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide
E Deforzh, P Kharel, A Karelin, P Ivanov, AM Krichevsky
bioRxiv, 2023
12023
Identification of oxidized mitochondrial mRNA in human neurons under oxidative stress
J Rana, P Kharel, S Basu
The FASEB Journal 33 (S1), 651.21-651.21, 2019
12019
Identification of bona fide RNA G-quadruplex binding proteins.
P Kharel, P Ivanov
Methods in Enzymology 695, 255-274, 2023
2023
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