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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin RD Morin, NA Johnson, TM Severson, AJ Mungall, J An, R Goya, JE Paul, ... Nature genetics 42 (2), 181-185, 2010 | 1957 | 2010 |
PyClone: statistical inference of clonal population structure in cancer A Roth, J Khattra, D Yap, A Wan, E Laks, J Biele, G Ha, S Aparicio, ... Nature methods 11 (4), 396-398, 2014 | 948 | 2014 |
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation DB Yap, J Chu, T Berg, M Schapira, SWG Cheng, A Moradian, RD Morin, ... Blood, The Journal of the American Society of Hematology 117 (8), 2451-2459, 2011 | 706 | 2011 |
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution P Eirew, A Steif, J Khattra, G Ha, D Yap, H Farahani, K Gelmon, S Chia, ... Nature 518 (7539), 422-426, 2015 | 654 | 2015 |
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ... Nature communications 8 (1), 14432, 2017 | 472 | 2017 |
TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data G Ha, A Roth, J Khattra, J Ho, D Yap, LM Prentice, N Melnyk, ... Genome research 24 (11), 1881-1893, 2014 | 395 | 2014 |
Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer A McPherson, A Roth, E Laks, T Masud, A Bashashati, AW Zhang, G Ha, ... Nature genetics 48 (7), 758-767, 2016 | 340 | 2016 |
Histological transformation and progression in follicular lymphoma: a clonal evolution study R Kridel, FC Chan, A Mottok, M Boyle, P Farinha, K Tan, B Meissner, ... PLoS medicine 13 (12), e1002197, 2016 | 230 | 2016 |
Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage JK Hsieh, D Yap, DJ O’Connor, V Fogal, L Fallis, F Chan, S Zhong, X Lu Molecular and cellular biology 22 (1), 78-93, 2002 | 146 | 2002 |
mdm2: a bridge over the two tumour suppressors, p53 and Rb D Yap, JK Hsieh, FSG Chan, X Lu Oncogene 18 (53), 7681-7689, 1999 | 143 | 1999 |
Clonal genotype and population structure inference from single-cell tumor sequencing A Roth, A McPherson, E Laks, J Biele, D Yap, A Wan, MA Smith, ... Nature methods 13 (7), 573-576, 2016 | 122 | 2016 |
Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation M Heuser, DB Yap, M Leung, TR de Algara, A Tafech, S McKinney, ... Blood, The Journal of the American Society of Hematology 113 (7), 1432-1443, 2009 | 118 | 2009 |
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis T Berg, S Thoene, D Yap, T Wee, N Schoeler, P Rosten, E Lim, M Bilenky, ... Blood, The Journal of the American Society of Hematology 123 (25), 3914-3924, 2014 | 103 | 2014 |
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The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type Y Wang, SY Chen, AN Karnezis, S Colborne, ND Santos, JD Lang, ... The Journal of pathology 242 (3), 371-383, 2017 | 97 | 2017 |
ASPP1 and ASPP2 are new transcriptional targets of E2F V Fogal, NN Kartasheva, G Trigiante, S Llanos, D Yap, KH Vousden, X Lu Cell Death & Differentiation 12 (4), 369-376, 2005 | 87 | 2005 |
Weaver syndrome‐associated EZH2 protein variants show impaired histone methyltransferase function in vitro ASA Cohen, DB Yap, MES Lewis, C Chijiwa, MA Ramos‐Arroyo, ... Human mutation 37 (3), 301-307, 2016 | 78 | 2016 |
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors Y Wang, J Chen, W Yang, F Mo, J Senz, D Yap, MS Anglesio, B Gilks, ... Neoplasia 17 (8), 650-660, 2015 | 69 | 2015 |
A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation A Burleigh, S McKinney, J Brimhall, D Yap, P Eirew, S Poon, V Ng, A Wan, ... Breast Cancer Research 17, 1-21, 2015 | 58 | 2015 |