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Luke R.G. Pike, M.D., D.Phil.
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Regulation of autophagy by ATF4 in response to severe hypoxia
T Rzymski, M Milani, L Pike, F Buffa, HR Mellor, L Winchester, I Pires, ...
Oncogene 29 (31), 4424-4435, 2010
4222010
The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib
M Milani, T Rzymski, HR Mellor, L Pike, A Bottini, D Generali, AL Harris
Cancer research 69 (10), 4415-4423, 2009
3202009
Safety of combining radiotherapy with immune-checkpoint inhibition
WL Hwang, LRG Pike, TJ Royce, BA Mahal, JS Loeffler
Nature reviews Clinical oncology 15 (8), 477-494, 2018
2342018
The histone demethylase JMJD2B is regulated by estrogen receptor α and hypoxia, and is a key mediator of estrogen induced growth
J Yang, AM Jubb, L Pike, FM Buffa, H Turley, D Baban, R Leek, KC Gatter, ...
Cancer research 70 (16), 6456-6466, 2010
2002010
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
LRG Pike, DC Singleton, F Buffa, O Abramczyk, K Phadwal, JL Li, ...
Biochemical Journal 449 (2), 389-400, 2013
1632013
Multicenter evaluation of the tolerability of combined treatment with PD-1 and CTLA-4 immune checkpoint inhibitors and palliative radiation therapy
A Bang, TJ Wilhite, LRG Pike, DN Cagney, AA Aizer, A Taylor, A Spektor, ...
International Journal of Radiation Oncology* Biology* Physics 98 (2), 344-351, 2017
1582017
A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells
K Phadwal, J Alegre-Abarrategui, AS Watson, L Pike, S Anbalagan, ...
autophagy 8 (4), 677-689, 2012
1582012
The impact of radiation therapy on lymphocyte count and survival in metastatic cancer patients receiving PD-1 immune checkpoint inhibitors
LRG Pike, A Bang, BA Mahal, A Taylor, M Krishnan, A Spektor, ...
International Journal of Radiation Oncology* Biology* Physics 103 (1), 142-151, 2019
1352019
The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress
T Rzymski, A Petry, D Kračun, F Riess, L Pike, AL Harris, A Görlach
Oncogene 31 (31), 3621-3634, 2012
882012
Radiation and PD-1 inhibition: favorable outcomes after brain-directed radiation
LRG Pike, A Bang, P Ott, T Balboni, A Taylor, P Catalano, B Rawal, ...
Radiotherapy and Oncology 124 (1), 98-103, 2017
582017
ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia
LRG Pike, K Phadwal, AK Simon, AL Harris
Molecular biology reports 39, 10811-10822, 2012
362012
Outcomes of HPV-associated squamous cell carcinoma of the head and neck: impact of race and socioeconomic status
LRG Pike, TJ Royce, AR Mahal, DW Kim, WL Hwang, BA Mahal, ...
Journal of the National Comprehensive Cancer Network 18 (2), 177-184, 2020
282020
YU238259 is a novel inhibitor of homology-dependent DNA repair that exhibits synthetic lethality and radiosensitization in repair-deficient tumors
GC Stachelek, E Peterson-Roth, Y Liu, RJ Fernandez III, LRG Pike, ...
Molecular Cancer Research 13 (10), 1389-1397, 2015
222015
Conservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database
AR Mahal, S Butler, I Franco, V Muralidhar, D Larios, LRG Pike, SG Zhao, ...
Cancer 125 (19), 3338-3346, 2019
202019
Trimodality therapy for HPV-positive oropharyngeal cancer: a population-based study: trimodality therapy for HPV+ OPC
NN Sanford, WL Hwang, LRG Pike, AC Lam, TJ Royce, BA Mahal
Oral oncology 98, 28-34, 2019
142019
31st annual meeting and associated programs of the society for immunotherapy of cancer (Sitc 2016): Part two: National harbor, md, USA. 9-13 November 2016
C Ager, M Reilley, C Nicholas, T Bartkowiak, A Jaiswal, M Curran, ...
Journal for ImmunoTherapy of Cancer 4, 107-221, 2016
122016
Fractionated proton radiation therapy and hearing preservation for vestibular schwannoma: preliminary analysis of a prospective phase 2 clinical trial
A Saraf, LRG Pike, KH Franck, NK Horick, BY Yeap, BC Fullerton, ...
Neurosurgery 90 (5), 506-514, 2022
102022
Palliative radiation therapy for vertebral metastases and metastatic cord compression in patients treated with anti-PD-1 therapy
MM Fareed, LRG Pike, A Bang, MA Huynh, A Taylor, A Spektor, MM Awad, ...
Frontiers in Oncology 9, 199, 2019
102019
Time to prostate-specific antigen nadir and the risk of death from prostate cancer following radiation and androgen deprivation therapy
LRG Pike, J Wu, MH Chen, M Loffredo, AA Renshaw, J Pfail, PW Kantoff, ...
Urology 126, 145-151, 2019
92019
Recent advances and applications of radiation therapy for brain metastases
NJ Mathis, NA Wijetunga, BS Imber, LRG Pike, JT Yang
Current Oncology Reports 24 (3), 335-342, 2022
82022
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