|Interleukin 6 is required for the development of collagen-induced arthritis|
T Alonzi, E Fattori, D Lazzaro, P Costa, L Probert, G Kollias, ...
The Journal of experimental medicine 187 (4), 461-468, 1998
|Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis|
F De Benedetti, HI Brunner, N Ruperto, A Kenwright, S Wright, I Calvo, ...
New England Journal of Medicine 367 (25), 2385-2395, 2012
|Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.|
F De Benedetti, T Alonzi, A Moretta, D Lazzaro, P Costa, V Poli, A Martini, ...
The Journal of clinical investigation 99 (4), 643-650, 1997
|Correlation of serum interleukin‐6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis|
F De Benedetti, M Massa, P Robbioni, A Ravelli, GR Burgio, A Martini
Arthritis & Rheumatism: Official Journal of the American College of …, 1991
|2016 Classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a European league against rheumatism/American College of …|
A Ravelli, F Minoia, S Davì, AC Horne, F Bovis, A Pistorio, M Aricò, ...
Annals of the Rheumatic Diseases 75 (3), 481-489, 2016
|Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile …|
R Donn, Z Alourfi, F De Benedetti, C Meazza, E Zeggini, M Lunt, ...
Arthritis & Rheumatism 46 (9), 2402-2409, 2002
|Impaired skeletal development in interleukin‐6–transgenic mice: A model for the impact of chronic inflammation on the growing skeletal system|
F De Benedetti, N Rucci, A Del Fattore, B Peruzzi, R Paro, M Longo, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2006
|Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2011|
DE Furst, EC Keystone, J Braun, FC Breedveld, GR Burmester, ...
Annals of the rheumatic diseases 71 (Suppl 2), i2-i45, 2012
|Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis.|
F De Benedetti, M Massa, P Pignatti, S Albani, D Novick, A Martini
The Journal of clinical investigation 93 (5), 2114-2119, 1994
|Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2009|
DE Furst, EC Keystone, R Fleischmann, P Mease, FC Breedveld, ...
Annals of the Rheumatic Diseases 69 (Suppl 1), i2-i29, 2010
|Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis|
M Cazzola, L Ponchio, F De Benedetti, A Ravelli, V Rosti, Y Beguin, ...
|Functional and prognostic relevance of the− 173 polymorphism of the macrophage migration inhibitory factor gene in systemic‐onset juvenile idiopathic arthritis|
F De Benedetti, C Meazza, M Vivarelli, F Rossi, A Pistorio, R Lamb, ...
Arthritis & Rheumatism 48 (5), 1398-1407, 2003
|Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2008|
DE Furst, EC Keystone, B Kirkham, R Fleischmann, P Mease, ...
Annals of the Rheumatic Diseases 67 (Suppl 3), iii2-iii25, 2008
|Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial|
HI Brunner, N Ruperto, Z Zuber, C Keane, O Harari, A Kenwright, P Lu, ...
Annals of the rheumatic diseases 74 (6), 1110-1117, 2015
|Is systemic juvenile rheumatoid arthritis an interleukin 6 mediated disease?|
F De Benedetti
J Rheumatol 25 (2), 203-207, 1998
|Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis|
SJ Vastert, R Van Wijk, LE D’Urbano, KMK De Vooght, W De Jager, ...
Rheumatology 49 (3), 441-449, 2010
|Effect of IL-6 on IGF binding protein-3: a study in IL-6 transgenic mice and in patients with systemic juvenile idiopathic arthritis|
F De Benedetti, C Meazza, M Oliveri, P Pignatti, M Vivarelli, T Alonzi, ...
Endocrinology 142 (11), 4818-4826, 2001
|Macrophage activation syndrome in systemic juvenile rheumatoid arthritis successfully treated with cyclosporine|
A Ravelli, F De Benedetti, S Viola, A Martini
The Journal of pediatrics 128 (2), 275-278, 1996
|An international registry on autoinflammatory diseases: the Eurofever experience|
N Toplak, J Frenkel, S Ozen, HJ Lachmann, P Woo, I Koné-Paut, ...
Annals of the rheumatic diseases 71 (7), 1177-1182, 2012
|A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis|
R Donn, Z Alourfi, E Zeggini, R Lamb, F Jury, M Lunt, ...
Arthritis & Rheumatism 50 (5), 1604-1610, 2004