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Wei Zhang
Wei Zhang
Associate Professor, Department of Molecular and Cellular Biology, University of Guelph
Verified email at uoguelph.ca - Homepage
Title
Cited by
Cited by
Year
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
MD Canny, N Moatti, LCK Wan, A Fradet-Turcotte, D Krasner, ...
Nature biotechnology 36 (1), 95-102, 2018
2492018
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes
W Zhang, KP Wu, MA Sartori, HB Kamadurai, A Ordureau, C Jiang, ...
Molecular cell 62 (1), 121-136, 2016
1712016
Dynamics of PARKIN-dependent mitochondrial ubiquitylation in induced neurons and model systems revealed by digital snapshot proteomics
A Ordureau, JA Paulo, W Zhang, T Ahfeldt, J Zhang, EF Cohn, Z Hou, ...
Molecular cell 70 (2), 211-227. e8, 2018
1572018
Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C
NG Brown, R VanderLinden, ER Watson, F Weissmann, A Ordureau, ...
Cell 165 (6), 1440-1453, 2016
1452016
Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation
M Yamaguchi, R VanderLinden, F Weissmann, R Qiao, P Dube, ...
Molecular cell 63 (4), 593-607, 2016
1402016
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination
L O'Donnell, S Panier, J Wildenhain, JM Tkach, A Al-Hakim, MC Landry, ...
Molecular cell 40 (4), 619-631, 2010
1402010
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
RS Banh, C Iorio, R Marcotte, Y Xu, D Cojocari, AA Rahman, J Pawling, ...
Nature cell biology 18 (7), 803-813, 2016
1132016
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine
DYL Mao, D Neculai, M Downey, S Orlicky, YZ Haffani, DF Ceccarelli, ...
Molecular cell 32 (2), 259-275, 2008
1072008
Development of inhibitors in the ubiquitination cascade
W Zhang, SS Sidhu
FEBS letters 588 (2), 356-367, 2014
992014
De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks
W Zhang, D Durocher
Genes & Development 24 (5), 502-515, 2010
982010
DNA damage signalling targets the kinetochore to promote chromatin mobility
J Strecker, GD Gupta, W Zhang, M Bashkurov, MC Landry, L Pelletier, ...
Nature cell biology 18 (3), 281-290, 2016
952016
Perinuclear tethers license telomeric DSBs for a broad kinesin-and NPC-dependent DNA repair process
DKC Chung, JNY Chan, J Strecker, W Zhang, S Ebrahimi-Ardebili, T Lu, ...
Nature Communications 6, 2015
832015
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants
W Zhang, BA Bailey-Elkin, RCM Knaap, B Khare, TJ Dalebout, ...
PLoS pathogens 13 (5), e1006372, 2017
622017
Emerging drug development technologies targeting ubiquitination for cancer therapeutics
G Veggiani, MCR Gerpe, SS Sidhu, W Zhang
Pharmacology & therapeutics 199, 139-154, 2019
592019
Targeting UBE4A revives viperin protein in epithelium to enhance host antiviral defense
Y Yuan, Y Miao, L Qian, Y Zhang, C Liu, J Liu, Y Zuo, Q Feng, T Guo, ...
Molecular cell 77 (4), 734-747. e7, 2020
582020
A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants
M Gabrielsen, L Buetow, MA Nakasone, SF Ahmed, GJ Sibbet, BO Smith, ...
Molecular cell 68 (2), 456-470. e10, 2017
572017
Generation and validation of intracellular ubiquitin variant inhibitors for USP7 and USP10
W Zhang, MA Sartori, T Makhnevych, KE Federowicz, X Dong, L Liu, ...
Journal of molecular biology 429 (22), 3546-3560, 2017
532017
Targeting the ubiquitin-proteasome system for cancer therapeutics by small-molecule inhibitors
G LaPlante, W Zhang
Cancers 13 (12), 3079, 2021
482021
Targeting the ubiquitin signaling cascade in tumor microenvironment for cancer therapy
Q Liu, B Aminu, O Roscow, W Zhang
International journal of molecular sciences 22 (2), 791, 2021
282021
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site
ER Watson, CRR Grace, W Zhang, DJ Miller, IF Davidson, JR Prabu, S Yu, ...
Proceedings of the National Academy of Sciences 116 (35), 17280-17289, 2019
262019
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