Wei Zhang
Wei Zhang
Assistant Professor, Department of Molecular and Cellular Biology, University of Guelph
Verified email at - Homepage
Cited by
Cited by
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
MD Canny, N Moatti, LCK Wan, A Fradet-Turcotte, D Krasner, ...
Nature biotechnology 36 (1), 95-102, 2018
System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes
W Zhang, KP Wu, MA Sartori, HB Kamadurai, A Ordureau, C Jiang, ...
Molecular cell 62 (1), 121-136, 2016
Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation
M Yamaguchi, R VanderLinden, F Weissmann, R Qiao, P Dube, ...
Molecular Cell 63 (4), 593-607, 2016
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
NG Brown, R VanderLinden, ER Watson, F Weissmann, A Ordureau, ...
Cell 165 (6), 1440-1453, 2016
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination
L O'Donnell, S Panier, J Wildenhain, JM Tkach, A Al-Hakim, MC Landry, ...
Molecular cell 40 (4), 619-631, 2010
Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics
A Ordureau, JA Paulo, W Zhang, T Ahfeldt, J Zhang, EF Cohn, Z Hou, ...
Molecular cell 70 (2), 211-227. e8, 2018
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine
DYL Mao, D Neculai, M Downey, S Orlicky, YZ Haffani, DF Ceccarelli, ...
Molecular cell 32 (2), 259-275, 2008
Development of inhibitors in the ubiquitination cascade
W Zhang, SS Sidhu
FEBS letters 588 (2), 356-367, 2014
De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks
W Zhang, D Durocher
Genes & development 24 (5), 502-515, 2010
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
RS Banh, C Iorio, R Marcotte, Y Xu, D Cojocari, AA Rahman, J Pawling, ...
Nature cell biology 18 (7), 803-813, 2016
DNA damage signalling targets the kinetochore to promote chromatin mobility
J Strecker, GD Gupta, W Zhang, M Bashkurov, MC Landry, L Pelletier, ...
Nature cell biology 18 (3), 281-290, 2016
Perinuclear tethers license telomeric DSBs for a broad kinesin-and NPC-dependent DNA repair process
DKC Chung, JNY Chan, J Strecker, W Zhang, S Ebrahimi-Ardebili, T Lu, ...
Nature Communications 6, 2015
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants
W Zhang, BA Bailey-Elkin, RCM Knaap, B Khare, TJ Dalebout, ...
PLoS pathogens 13 (5), e1006372, 2017
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
M Gabrielsen, L Buetow, MA Nakasone, SF Ahmed, GJ Sibbet, BO Smith, ...
Molecular cell 68 (2), 456-470. e10, 2017
Emerging drug development technologies targeting ubiquitination for cancer therapeutics
G Veggiani, MCR Gerpe, SS Sidhu, W Zhang
Pharmacology & therapeutics 199, 139-154, 2019
Generation and validation of intracellular ubiquitin variant Inhibitors for USP7 and USP10
W Zhang, MA Sartori, T Makhnevych, KE Federowicz, X Dong, L Liu, ...
Journal of molecular biology 429 (22), 3546-3560, 2017
Targeting UBE4A revives viperin protein in epithelium to enhance host antiviral defense
Y Yuan, Y Miao, L Qian, Y Zhang, C Liu, J Liu, Y Zuo, Q Feng, T Guo, ...
Molecular Cell 77 (4), 734-747. e7, 2020
Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors
G LaPlante, W Zhang
Cancers 13 (12), 3079, 2021
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site
ER Watson, CRR Grace, W Zhang, DJ Miller, IF Davidson, JR Prabu, S Yu, ...
Proceedings of the National Academy of Sciences 116 (35), 17280-17289, 2019
Engineering cell signaling modulators from native protein–protein interactions
W Zhang, M Ben-David, SS Sidhu
Current Opinion in Structural Biology 45, 25-35, 2017
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