Wei Zhang

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Sachdev SidhuUniversity of WaterlooVerified email at uwaterloo.ca
Daniel DurocherThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and Department of MolecularVerified email at lunenfeld.ca
frank sicheriLunenfeld-Tanenbaum Research Institute, Mount Sinai HospitalVerified email at lunenfeld.ca
Andreas ErnstInstitute of Clinical Pharmacology, Goethe-University FrankfurtVerified email at em.uni-frankfurt.de
Jan-Michael PetersResearch Institute of Molecular Pathology (IMP)Verified email at imp.ac.at
Amélie Fradet-TurcotteAssociate professor, Dept. of Molecular Biology, Medical Biochemistry and Pathology, UniversitéVerified email at crchudequebec.ulaval.ca
Alexandre ORTHWEINMcGill UniversityVerified email at mcgill.ca
Benjamin G. NeelProfessor of Medicine, NYU School of Medicine; Director, Laura and Isaac Perlmutter Cancer CenterVerified email at nyulangone.org
Robert BanhNew York UniversityVerified email at nyulangone.org
Jonathan StreckerAssistant Professor, MGH/HMSVerified email at hms.harvard.edu
J.Wade HarperProfessor of Cell BiologyVerified email at hms.harvard.edu
Alban ORDUREAUCell Biology Program, Sloan Kettering InstituteVerified email at mskcc.org
anne-claude gingrasLunenfeld-Tanenbaum Research Institute; University of TorontoVerified email at lunenfeld.ca
Stephanie PanierMax Planck Research Group Leader, MPI-Age Cologne and University of CologneVerified email at age.mpg.de
Grant W BrownUniversity of TorontoVerified email at utoronto.ca
Mike TyersThe Hospital for Sick ChildrenVerified email at sickkids.ca
Robert G BristowUniversity of ManchesterVerified email at manchester.ac.uk
Michael DowneyUniversity of OttawaVerified email at uottawa.ca
Brian L. MarkUniversity of ManitobaVerified email at umanitoba.ca
Gianluca VeggianiLouisiana State UniversityVerified email at lsu.edu

Wei Zhang

Associate Professor, Department of Molecular and Cellular Biology, University of Guelph

Verified email at uoguelph.ca - Homepage

ubiquitin signaling protein engineering targeted protein degradation genome stability


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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹ DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021	10664	2021
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency MD Canny, N Moatti, LCK Wan, A Fradet-Turcotte, D Krasner, ... Nature biotechnology 36 (1), 95-102, 2018	251	2018
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes W Zhang, KP Wu, MA Sartori, HB Kamadurai, A Ordureau, C Jiang, ... Molecular cell 62 (1), 121-136, 2016	172	2016
Dynamics of PARKIN-dependent mitochondrial ubiquitylation in induced neurons and model systems revealed by digital snapshot proteomics A Ordureau, JA Paulo, W Zhang, T Ahfeldt, J Zhang, EF Cohn, Z Hou, ... Molecular cell 70 (2), 211-227. e8, 2018	159	2018
Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C NG Brown, R VanderLinden, ER Watson, F Weissmann, A Ordureau, ... Cell 165 (6), 1440-1453, 2016	146	2016
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination L O'Donnell, S Panier, J Wildenhain, JM Tkach, A Al-Hakim, MC Landry, ... Molecular cell 40 (4), 619-631, 2010	142	2010
Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation M Yamaguchi, R VanderLinden, F Weissmann, R Qiao, P Dube, ... Molecular cell 63 (4), 593-607, 2016	141	2016
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia RS Banh, C Iorio, R Marcotte, Y Xu, D Cojocari, AA Rahman, J Pawling, ... Nature cell biology 18 (7), 803-813, 2016	114	2016
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine DYL Mao, D Neculai, M Downey, S Orlicky, YZ Haffani, DF Ceccarelli, ... Molecular cell 32 (2), 259-275, 2008	107	2008
Development of inhibitors in the ubiquitination cascade W Zhang, SS Sidhu FEBS letters 588 (2), 356-367, 2014	100	2014
De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks W Zhang, D Durocher Genes & Development 24 (5), 502-515, 2010	98	2010
DNA damage signalling targets the kinetochore to promote chromatin mobility J Strecker, GD Gupta, W Zhang, M Bashkurov, MC Landry, L Pelletier, ... Nature cell biology 18 (3), 281-290, 2016	95	2016
Perinuclear tethers license telomeric DSBs for a broad kinesin-and NPC-dependent DNA repair process DKC Chung, JNY Chan, J Strecker, W Zhang, S Ebrahimi-Ardebili, T Lu, ... Nature Communications 6, 2015	84	2015
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants W Zhang, BA Bailey-Elkin, RCM Knaap, B Khare, TJ Dalebout, ... PLoS pathogens 13 (5), e1006372, 2017	64	2017
Emerging drug development technologies targeting ubiquitination for cancer therapeutics G Veggiani, MCR Gerpe, SS Sidhu, W Zhang Pharmacology & therapeutics 199, 139-154, 2019	60	2019
A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants M Gabrielsen, L Buetow, MA Nakasone, SF Ahmed, GJ Sibbet, BO Smith, ... Molecular cell 68 (2), 456-470. e10, 2017	59	2017
Targeting UBE4A revives viperin protein in epithelium to enhance host antiviral defense Y Yuan, Y Miao, L Qian, Y Zhang, C Liu, J Liu, Y Zuo, Q Feng, T Guo, ... Molecular cell 77 (4), 734-747. e7, 2020	58	2020
A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects J Zhang, V Lachance, A Schaffner, X Li, A Fedick, LE Kaye, J Liao, ... PLoS genetics 12 (4), e1005848, 2016	58	2016
CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma R Zhao, J Ni, S Lu, S Jiang, L You, H Liu, J Shou, C Zhai, W Zhang, ... Aging (Albany NY) 11 (19), 8484, 2019	55	2019
Generation and validation of intracellular ubiquitin variant inhibitors for USP7 and USP10 W Zhang, MA Sartori, T Makhnevych, KE Federowicz, X Dong, L Liu, ... Journal of molecular biology 429 (22), 3546-3560, 2017	54	2017

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