R Tyndale
R Tyndale
Unknown affiliation
Verified email at utoronto.ca
TitleCited byYear
Guidelines on nicotine dose selection for in vivo research
SG Matta, DJ Balfour, NL Benowitz, RT Boyd, JJ Buccafusco, ...
Psychopharmacology 190 (3), 269-319, 2007
6342007
Pharmacogenetics
W Kalow, DM Grant
Heredity and the response to drugs. London: Saunders Company 12, 1962
6281962
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct …
T Aoyama, S Yamano, DJ Waxman, DP Lapenson, UA Meyer, V Fischer, ...
Journal of Biological Chemistry 264 (18), 10388-10395, 1989
5261989
Nicotine metabolism defect reduces smoking
ML Pianezza, EM Sellers, RF Tyndale
Nature 393 (6687), 750, 1998
5211998
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes
ES Messina, RF Tyndale, EM Sellers
Journal of Pharmacology and Experimental Therapeutics 282 (3), 1608-1614, 1997
4881997
Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity
D Dempsey, P Tutka, P Jacob III, F Allen, K Schoedel, RF Tyndale, ...
Clinical Pharmacology & Therapeutics 76 (1), 64-72, 2004
3672004
Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence
V Malaiyandi, EM Sellers, RF Tyndale
Clinical Pharmacology & Therapeutics 77 (3), 145-158, 2005
3092005
Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians
KA Schoedel, EB Hoffmann, Y Rao, EM Sellers, RF Tyndale
Pharmacogenetics and Genomics 14 (9), 615-626, 2004
3072004
Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking
Y Rao, E Hoffmann, M Zia, L Bodin, M Zeman, EM Sellers, RF Tyndale
Molecular Pharmacology 58 (4), 747-755, 2000
3042000
Nicotine-dependence symptoms are associated with smoking frequency in adolescents
J O'Loughlin, J DiFranza, RF Tyndale, G Meshefedjian, E McMillan-Davey, ...
American journal of preventive medicine 25 (3), 219-225, 2003
2712003
Genetics of alcohol and tobacco use in humans
RF Tyndale
Annals of medicine 35 (2), 94-121, 2003
2622003
Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation
C Lerman, R Tyndale, F Patterson, EP Wileyto, PG Shields, A Pinto, ...
Clinical Pharmacology & Therapeutics 79 (6), 600-608, 2006
2572006
The pharmacogenetics research network: from SNP discovery to clinical drug response
KM Giacomini, CM Brett, RB Altman, NL Benowitz, ME Dolan, ...
Clinical Pharmacology & Therapeutics 81 (3), 328-345, 2007
2522007
The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H] GBR-12935 binding proteins
HB Niznik, RF Tyndale, FR Sallee, FJ Gonzalez, JP Hardwick, T Inaba, ...
Archives of biochemistry and biophysics 276 (2), 424-432, 1990
2371990
Inhibition of cytochromes P450 by antifungal imidazole derivatives
W Zhang, Y Ramamoorthy, T Kilicarslan, H Nolte, RF Tyndale, EM Sellers
Drug Metabolism and Disposition 30 (3), 314-318, 2002
2302002
Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking
EM Sellers, HL Kaplan, RF Tyndale
Clinical Pharmacology & Therapeutics 68 (1), 35-43, 2000
2102000
Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
S Miksys, C Lerman, PG Shields, DC Mash, RF Tyndale
Neuropharmacology 45 (1), 122-132, 2003
2072003
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine
NL Benowitz, GE Swan, P Jacob III, CN Lessov‐Schlaggar, RF Tyndale
Clinical Pharmacology & Therapeutics 80 (5), 457-467, 2006
2012006
Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy
V Malaiyandi, C Lerman, NL Benowitz, C Jepson, F Patterson, ...
Molecular psychiatry 11 (4), 400, 2006
1892006
Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk
RF Tyndale, EM Sellers
Drug Metabolism and Disposition 29 (4), 548-552, 2001
1862001
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