Gary Lopaschuk
Gary Lopaschuk
Professor, Pediatrics, Universit of Alberta
Verified email at
Cited by
Cited by
Myocardial substrate metabolism in the normal and failing heart
WC Stanley, FA Recchia, GD Lopaschuk
Physiological reviews 85 (3), 1093-1129, 2005
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ...
Cell metabolism 7 (1), 45-56, 2008
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
S Bonnet, SL Archer, J Allalunis-Turner, A Haromy, C Beaulieu, ...
Cancer cell 11 (1), 37-51, 2007
Myocardial fatty acid metabolism in health and disease
GD Lopaschuk, JR Ussher, CDL Folmes, JS Jaswal, WC Stanley
Physiological reviews 90 (1), 207-258, 2010
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A …
PF Kantor, A Lucien, R Kozak, GD Lopaschuk
Circulation research 86 (5), 580-588, 2000
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
BN Finck, JJ Lehman, TC Leone, MJ Welch, MJ Bennett, A Kovacs, X Han, ...
The Journal of clinical investigation 109 (1), 121-130, 2002
Heart physiology: from cell to circulation
LH Opie
Lippincott Williams & Wilkins, 2004
AT Yan, AJ Shayne, KA Brown, SN Gupta, CW Chan, TM Luu, MF Di Carli, ...
Circulation 114 (1), 32-39, 2006
Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions: potential for pharmacological interventions
WC Stanley, GD Lopaschuk, JL Hall, JG McCormack
Cardiovascular research 33 (2), 243-257, 1997
Regulation of fatty acid oxidation in the mammalian heart in health and disease
GD Lopaschuk, DD Belke, J Gamble, I Toshiyuki, BO Schönekess
Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism 1213 (3 …, 1994
High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMP-activated protein …
N Kudo, AJ Barr, RL Barr, S Desai, GD Lopaschuk
Journal of Biological Chemistry 270 (29), 17513-17520, 1995
Regulation of energy substrate metabolism in the diabetic heart
WC Stanley, GD Lopaschuk, JG McCormack
Cardiovascular research 34 (1), 25-33, 1997
Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts
MF Allard, BO Schonekess, SL Henning, DR English, GD Lopaschuk
American Journal of Physiology-Heart and Circulatory Physiology 267 (2 …, 1994
Cardiovascular remodelling in coronary artery disease and heart failure
G Heusch, P Libby, B Gersh, D Yellon, M Böhm, G Lopaschuk, L Opie
The Lancet 383 (9932), 1933-1943, 2014
Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts.
M Saddik, GD Lopaschuk
Journal of Biological Chemistry 266 (13), 8162-8170, 1991
Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart.
M Saddik, J Gamble, LA Witters, GD Lopaschuk
Journal of Biological Chemistry 268 (34), 25836-25845, 1993
AMPK alterations in cardiac physiology and pathology: enemy or ally?
JRB Dyck, GD Lopaschuk
The Journal of physiology 574 (1), 95-112, 2006
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated …
ED Michelakis, MS McMurtry, XC Wu, JRB Dyck, R Moudgil, TA Hopkins, ...
Circulation 105 (2), 244-250, 2002
Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts
JG McCormack, RL Barr, AA Wolff, GD Lopaschuk
Circulation 93 (1), 135-142, 1996
An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic …
GD Lopaschuk, RB Wambolt, RL Barr
Journal of Pharmacology and Experimental Therapeutics 264 (1), 135-144, 1993
The system can't perform the operation now. Try again later.
Articles 1–20