Philip Seeman
Philip Seeman
pharmacology and psychiatry University of Toronto
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The membrane actions of anesthetics and tranquilizers
P Seeman
Pharmacol rev 24 (4), 583-655, 1972
Brain dopamine recepotrs
P Seeman
Pharmacol Rev 32, 229-313, 1981
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
HHM Van Tol, JR Bunzow, HC Guan, RK Sunahara, P Seeman, ...
Nature 350 (6319), 610-614, 1991
Antipsychotic drug doses and neuroleptic/dopamine receptors
P Seeman, T Lee, M Chau-Wong, K Wong
Nature 261 (5562), 717-719, 1976
Does Fast Dissociation From the Dopamine D2 Receptor Explain the Action of Atypical Antipsychotics?: A New Hypothesis
S Kapur, P Seeman
American Journal of Psychiatry 158 (3), 360-369, 2001
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
RK Sunahara, HC Guan, BF O'Dowd, P Seeman, LG Laurier, G Ng, ...
Nature 350 (6319), 614-619, 1991
Radioreceptor binding profile of the atypical antipsychotic olanzapine
FP Bymaster, DO Calligaro, JF Falcone, RD Marsh, NA Moore, NC Tye, ...
Neuropsychopharmacology 14 (2), 87-96, 1996
Atypical antipsychotics: mechanism of action
P Seeman
The Canadian Journal of Psychiatry 47 (1), 27-38, 2002
Multiple dopamine D4 receptor variants in the human population
HHMV Tol, CM Wu, HC Guan, K Ohara, JR Bunzow, O Civelli, J Kennedy, ...
Nature 358 (6382), 149-152, 1992
Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons
P Seeman, T Lee
Science 188 (4194), 1217-1219, 1975
Dopamine receptors and the dopamine hypothesis of schizophrenia
P Seeman
Synapse 1 (2), 133-152, 1987
Dopamine receptor pharmacology
P Seeman, HHM Van Tol
Trends in pharmacological sciences 15 (7), 264-270, 1994
Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
P Seeman, M Chau-Wong, J Tedesco, K Wong
Proceedings of the National Academy of Sciences 72 (11), 4376-4380, 1975
Dopamine D4 receptors elevated in schizophrenia
P Seeman, HC Guan, HHM Van Tol
Nature 365 (6445), 441-445, 1993
Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4.
P Seeman
Neuropsychopharmacology: official publication of the American College of …, 1992
D1 and D2 dopamine receptor mRNA in rat brain.
DM Weiner, AI Levey, RK Sunahara, HB Niznik, BF O'Dowd, P Seeman, ...
Proceedings of the national academy of sciences 88 (5), 1859-1863, 1991
Human dopamine D1 receptor encoded by an intronless gene on chromosome 5
RK Sunahara, HB Niznik, DM Weiner, TM Stormann, MR Brann, ...
Nature 347 (6288), 80-83, 1990
Receptor basis for dopaminergic supersensitivity in Parkinson's disease
T Lee, P Seeman, A Rajput, IJ FARLEY, O Hornykiewicz
Nature 273 (5657), 59-61, 1978
NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D2 and serotonin 5-HT2 receptors—implications for models of schizophrenia
S Kapur, P Seeman
Molecular psychiatry 7 (8), 837-844, 2002
A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy
S Kapur, R Zipursky, C Jones, CS Shammi, G Remington, P Seeman
Archives of general psychiatry 57 (6), 553-559, 2000
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