| Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications ZC Hartman, DM Appledorn, A Amalfitano Virus research 132 (1-2), 1-14, 2008 | 314 | 2008 |
| Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo DM Appledorn, S Patial, A McBride, S Godbehere, N Van Rooijen, ... The Journal of Immunology 181 (3), 2134-2144, 2008 | 237 | 2008 |
| Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy SS Seregin, DM Appledorn, AJ McBride, NJ Schuldt, YA Aldhamen, ... Molecular Therapy 17 (4), 685-696, 2009 | 111 | 2009 |
| Bone inflammation and altered gene expression with type I diabetes early onset KJ Motyl, S Botolin, R Irwin, DM Appledorn, T Kadakia, A Amalfitano, ... Journal of cellular physiology 218 (3), 575-583, 2009 | 89 | 2009 |
| Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors DM Appledorn, A McBride, S Seregin, JM Scott, N Schuldt, A Kiang, ... Gene therapy 15 (24), 1606-1617, 2008 | 82 | 2008 |
| Campylobacter jejuni-Induced Activation of Dendritic Cells Involves Cooperative Signaling through Toll-Like Receptor 4 (TLR4)-MyD88 and TLR4-TRIF Axes VAK Rathinam, DM Appledorn, KA Hoag, A Amalfitano, LS Mansfield Infection and immunity 77 (6), 2499-2507, 2009 | 78 | 2009 |
| Regulation of lipopolysaccharide‐induced inflammatory response and endotoxemia by β‐arrestins KJ Porter, B Gonipeta, S Parvataneni, DM Appledorn, S Patial, D Sharma, ... Journal of cellular physiology 225 (2), 406-416, 2010 | 62 | 2010 |
| G‐protein coupled receptor kinase 5 mediates lipopolysaccharide‐induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice S Patial, S Shahi, Y Saini, T Lee, N Packiriswamy, DM Appledorn, ... Journal of cellular physiology 226 (5), 1323-1333, 2011 | 59 | 2011 |
| Wild-type adenoviruses from groups A–F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent DM Appledorn, A Kiang, A McBride, H Jiang, S Seregin, JM Scott, ... Gene therapy 15 (12), 885-901, 2008 | 59 | 2008 |
| Sublingual administration of an adenovirus serotype 5 (Ad5)-based vaccine confirms Toll-like receptor agonist activity in the oral cavity and elicits improved mucosal and … DM Appledorn, YA Aldhamen, S Godbehere, SS Seregin, A Amalfitano Clinical and Vaccine Immunology 18 (1), 150-160, 2011 | 57 | 2011 |
| Myeloid‐specific GPCR kinase‐2 negatively regulates NF‐κB1p105‐ERK pathway and limits endotoxemic shock in mice S Patial, Y Saini, S Parvataneni, DM Appledorn, GW Dorn, JJ LaPres, ... Journal of cellular physiology 226 (3), 627-637, 2011 | 49 | 2011 |
| Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector–triggered immune responses in vitro and in vivo SS Seregin, YA Aldhamen, DM Appledorn, ZC Hartman, NJ Schuldt, ... Blood, The Journal of the American Society of Hematology 116 (10), 1669-1677, 2010 | 45 | 2010 |
| A New Adenovirus Based Vaccine Vector Expressing an Eimeria tenella Derived TLR Agonist Improves Cellular Immune Responses to an Antigenic Target DM Appledorn, YA Aldhamen, W DePas, SS Seregin, CJJ Liu, N Schuldt, ... PLoS One 5 (3), e9579, 2010 | 42 | 2010 |
| Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens YA Aldhamen, DM Appledorn, SS Seregin, CJ Liu, NJ Schuldt, ... The Journal of Immunology 186 (2), 722-732, 2011 | 41 | 2011 |
| TRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses DM Appledorn, S Patial, S Godbehere, N Parameswaran, A Amalfitano Journal of innate immunity 1 (4), 376-388, 2009 | 40 | 2009 |
| Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the … ZC Hartman, DM Appledorn, D Serra, O Glass, TB Mendelson, TM Clay, ... Virology 374 (2), 453-467, 2008 | 35 | 2008 |
| β-Arrestins modulate Adenovirus-vector-induced innate immune responses: Differential regulation by β-arrestin-1 and β-arrestin-2 SS Seregin, DM Appledorn, S Patial, M Bujold, W Nance, S Godbehere, ... Virus research 147 (1), 123-134, 2010 | 27 | 2010 |
| CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies SS Seregin, YA Aldhamen, DM Appledorn, NJ Schuldt, AJ McBride, ... Gene therapy 16 (10), 1245-1259, 2009 | 24 | 2009 |
| TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo SS Seregin, YA Aldhamen, DM Appledorn, CF Aylsworth, S Godbehere, ... PloS one 6 (7), e22064, 2011 | 21 | 2011 |
| Novel adenovirus vectors ‘capsid-displaying’a human complement inhibitor SS Seregin, ZC Hartman, DM Appledorn, S Godbehere, H Jiang, ... Journal of innate immunity 2 (4), 353-359, 2010 | 21 | 2010 |
