Linda Z. Penn
Linda Z. Penn
Senior Scientist, Princess Margaret Cancer Centre, Toronto, Ontario Canada
Verified email at - Homepage
Cited by
Cited by
Induction of apoptosis in fibroblasts by c-myc protein
GI Evan, AH Wyllie, CS Gilbert, TD Littlewood, H Land, M Brooks, ...
Cell 69 (1), 119-128, 1992
Reflecting on 25 years with MYC
N Meyer, LZ Penn
Nature Reviews Cancer 8 (12), 976-990, 2008
HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis
WWL Wong, J Dimitroulakos, MD Minden, LZ Penn
Leukemia 16 (4), 508-519, 2002
The myc oncogene: marvelously complex
SK Oster, CSW Ho, EL Soucie, LZ Penn
Academic Press 84, 81-154, 2002
The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis
D Barsyte-Lovejoy, SK Lau, PC Boutros, F Khosravi, I Jurisica, IL Andrulis, ...
Cancer research 66 (10), 5330-5337, 2006
The molecular role of Myc in growth and transformation: recent discoveries lead to new insights
LM Facchini, LZ Penn
The FASEB Journal 12 (9), 633-651, 1998
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
MG Annis, EL Soucie, PJ Dlugosz, JA Cruz‐Aguado, LZ Penn, B Leber, ...
The EMBO journal 24 (12), 2096-2103, 2005
Bcl‐2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.
W Zhu, A Cowie, GW Wasfy, LZ Penn, B Leber, DW Andrews
The EMBO journal 15 (16), 4130-4141, 1996
Dysregulation of the mevalonate pathway promotes transformation
JW Clendening, A Pandyra, PC Boutros, S El Ghamrasni, F Khosravi, ...
Proceedings of the National Academy of Sciences 107 (34), 15051-15056, 2010
Three-gene prognostic classifier for early-stage non–small-cell lung cancer
SK Lau, PC Boutros, M Pintilie, FH Blackhall, CQ Zhu, D Strumpf, ...
Journal of Clinical Oncology 25 (35), 5562-5569, 2007
Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro
Y Shi, A Frankel, LG Radvanyi, LZ Penn, RG Miller, GB Mills
Cancer research 55 (9), 1982-1988, 1995
Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues
ABY Hui, W Shi, PC Boutros, N Miller, M Pintilie, T Fyles, D McCready, ...
Laboratory investigation 89 (5), 597-606, 2009
Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis
J Wu, WWL Wong, F Khosravi, MD Minden, LZ Penn
Cancer research 64 (18), 6461-6468, 2004
The interplay between cell signalling and the mevalonate pathway in cancer
PJ Mullen, R Yu, J Longo, MC Archer, LZ Penn
Nature Reviews Cancer 16 (11), 718, 2016
Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: a potential therapeutic approach
J Dimitroulakos, D Nohynek, KL Backway, DW Hedley, H Yeger, ...
Blood, The Journal of the American Society of Hematology 93 (4), 1308-1318, 1999
Bcl‐xL/Bcl‐2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry
YM Janumyan, CG Sansam, A Chattopadhyay, N Cheng, EL Soucie, ...
The EMBO journal 22 (20), 5459-5470, 2003
Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression
DYL Mao, JD Watson, PS Yan, D Barsyte-Lovejoy, F Khosravi, ...
Current Biology 13 (10), 882-886, 2003
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells
Z Xia, MM Tan, WWL Wong, J Dimitroulakos, MD Minden, LZ Penn
Leukemia 15 (9), 1398-1407, 2001
OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line–specific manner
AD Gonzalez, M Kaya, W Shi, H Song, JR Testa, LZ Penn, J Filmus
The Journal of cell biology 141 (6), 1407-1414, 1998
Prognostic gene signatures for non-small-cell lung cancer
PC Boutros, SK Lau, M Pintilie, N Liu, FA Shepherd, SD Der, MS Tsao, ...
Proceedings of the National Academy of Sciences 106 (8), 2824-2828, 2009
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