Osvaldo Andrade Santos-Filho
Osvaldo Andrade Santos-Filho
Professor of Physical Chemistry and Molecular Modeling, Federal University of Rio de Janeiro
Verified email at ippn.ufrj.br
Title
Cited by
Cited by
Year
Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection
LC Manjolin, MBG dos Reis, C do Carmo Maquiaveli, OA Santos-Filho, ...
Food chemistry 141 (3), 2253-2262, 2013
792013
Rational Design of New Antituberculosis Agents: Receptor-Independent Four-Dimensional Quantitative Structure− Activity Relationship Analysis of a Set of Isoniazid Derivatives
KFM Pasqualoto, EI Ferreira, OA Santos-Filho, AJ Hopfinger
Journal of medicinal chemistry 47 (15), 3755-3764, 2004
712004
Design, synthesis, and antiviral activity of new 1 H-1, 2, 3-triazole nucleoside ribavirin analogs
GF Maria de Lourdes, LCS Pinheiro, OA Santos-Filho, MDS Peçanha, ...
Medicinal Chemistry Research 23 (3), 1501-1511, 2014
702014
Modelagem de proteínas por homologia
OA Santos Filho, RB Alencastro
Química Nova 26, 253-259, 2003
662003
Mapping the Protein Interaction Network in Methicillin-Resistant Staphylococcus aureus
A Cherkasov, M Hsing, R Zoraghi, LJ Foster, RH See, N Stoynov, J Jiang, ...
Journal of proteome research 10 (3), 1139-1150, 2011
632011
Molecular modeling of wild-type and antifolate resistant mutant Plasmodium falciparum DHFR
RT Delfino, OA Santos-Filho, JD Figueroa-Villar
Biophysical chemistry 98 (3), 287-300, 2002
632002
Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis …
MBG dos Reis, LC Manjolin, CC Maquiaveli, OA Santos-Filho, ...
PLoS One 8 (11), e78387, 2013
582013
New trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents
N Boechat, L Pinheiro, TS Silva, ACC Aguiar, AS Carvalho, MM Bastos, ...
Molecules 17 (7), 8285-8302, 2012
562012
A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors
OA Santos-Filho, AJ Hopfinger
Journal of computer-aided molecular design 15 (1), 1-12, 2001
502001
Type 2 antifolates in the chemotherapy of falciparum malaria
RT Delfino, OA Santos-Filho, JD Figueroa-Villar
Journal of the Brazilian Chemical Society 13, 727-741, 2002
492002
Design and synthesis of new N-(5-trifluoromethyl)-1H-1, 2, 4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes
N Boechat, L Pinheiro, OA Santos-Filho, IC Silva
Molecules 16 (9), 8083-8097, 2011
472011
An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin
A Cherkasov, F Ban, O Santos-Filho, N Thorsteinson, M Fallahi, ...
Journal of medicinal chemistry 51 (7), 2047-2056, 2008
442008
Free energy force field (FEFF) 3D-QSAR analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors
OA Santos-Filho, RK Mishra, AJ Hopfinger
Journal of computer-aided molecular design 15 (9), 787-810, 2001
422001
The receptor-dependent QSAR paradigm: an overview of the current state of the art
OA Santos-Filho, AJ Hopfinger, A Cherkasov, RB de Alencastro
Medicinal Chemistry 5 (4), 359-366, 2009
382009
Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy …
OA Santos-Filho, RB de Alencastro, JD Figueroa-Villar
Biophysical chemistry 91 (3), 305-317, 2001
382001
Structure-based QSAR analysis of a set of 4-hydroxy-5, 6-dihydropyrones as inhibitors of HIV-1 protease: an application of the receptor-dependent (RD) 4D-QSAR formalism
OA Santos-Filho, AJ Hopfinger
Journal of chemical information and modeling 46 (1), 345-354, 2006
322006
The 4D‐QSAR Paradigm: Application to a Novel Set of Non‐peptidic HIV Protease Inhibitors
OA Santos‐Filho, AJ Hopfinger
Quantitative Structure‐Activity Relationships 21 (4), 369-381, 2002
282002
In silico identification of anthropogenic chemicals as ligands of zebrafish sex hormone binding globulin
N Thorsteinson, F Ban, O Santos-Filho, SMH Tabaei, S Miguel-Queralt, ...
Toxicology and applied pharmacology 234 (1), 47-57, 2009
272009
Molecular modeling of the interaction of trypanocide guanyl hydrazones with B-DNA
OA Santos-Filho, JD Figueroa-Villar, MT Araujo
Bioorganic & Medicinal Chemistry Letters 7 (13), 1797-1802, 1997
241997
A complete model of the Plasmodium falciparum bifunctional enzyme dihydrofolate reductase-thymidylate synthase: a model to design new antimalarials
TCC França, ALR de Medeiros, ECP dos Santos, OA Santos-Filho, ...
Journal of the Brazilian Chemical Society 15, 450-454, 2004
202004
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Articles 1–20