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Yu-Chen Liu
Yu-Chen Liu
Senior Scientist, Exelixis, Inc
Verified email at exelixis.com
Title
Cited by
Cited by
Year
Structure and mechanism of assembly line polyketide synthases
T Robbins, YC Liu, DE Cane, C Khosla
Current opinion in structural biology 41, 10-18, 2016
1522016
Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds
YC Liu, YS Li, SY Lyu, LJ Hsu, YH Chen, YT Huang, HC Chan, CJ Huang, ...
Nature Chemical Biology 7 (5), 304-309, 2011
612011
Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms
CY Chang, SY Lyu, YC Liu, NS Hsu, CC Wu, CF Tang, KH Lin, JY Ho, ...
Angewandte Chemie 126 (7), 1974-1979, 2014
562014
In vitro Characterization of Enzymes Involved in the Synthesis of Nonproteinogenic Residue (2S,3S)‐β‐Methylphenylalanine in Glycopeptide Antibiotic …
YT Huang, SY Lyu, PH Chuang, NS Hsu, YS Li, HC Chan, CJ Huang, ...
Chembiochem 10 (15), 2480-2487, 2009
482009
Solution structure of γ‐bungarotoxin: the functional significance of amino acid residues flanking the RGD motif in integrin binding
JH Shiu, CY Chen, LS Chang, YC Chen, YC Chen, YH Lo, YC Liu, ...
Proteins: Structure, Function, and Bioinformatics 57 (4), 839-849, 2004
422004
Structure–function analysis of the extended conformation of a polyketide synthase module
X Li, N Sevillano, F La Greca, L Deis, YC Liu, MC Deller, II Mathews, ...
Journal of the American Chemical Society 140 (21), 6518-6521, 2018
412018
Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
XW Zou, YC Liu, NS Hsu, CJ Huang, SY Lyu, HC Chan, CY Chang, ...
Acta Crystallographica Section D: Biological Crystallography 70 (6), 1549-1560, 2014
342014
Regioselective deacetylation based on teicoplanin-complexed Orf2* crystal structures
HC Chan, YT Huang, SY Lyu, CJ Huang, YS Li, YC Liu, CC Chou, ...
Molecular BioSystems 7 (4), 1224-1231, 2011
282011
Characterization and crystal structure of a nonheme diiron monooxygenase involved in platensimycin and platencin biosynthesis
LB Dong, YC Liu, AJ Cepeda, E Kalkreuter, MR Deng, JD Rudolf, ...
Journal of the American Chemical Society 141 (31), 12406-12412, 2019
272019
Multiple Complexes of Long Aliphatic N-Acyltransferases Lead to Synthesis of 2,6-Diacylated/2-Acyl-Substituted Glycopeptide Antibiotics, Effectively Killing …
SY Lyu, YC Liu, CY Chang, CJ Huang, YH Chiu, CM Huang, NS Hsu, ...
Journal of the American Chemical Society 136 (31), 10989-10995, 2014
252014
Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: Importance of the interactions between the D residue and integrin
CY Chen, JH Shiu, YH Hsieh, YC Liu, YC Chen, YC Chen, WY Jeng, ...
Proteins: Structure, Function, and Bioinformatics 76 (4), 808-821, 2009
252009
Combining biocatalysis and chemoselective chemistries for glycopeptide antibiotics modification
TL Li, YC Liu, SY Lyu
Current Opinion in Chemical Biology 16 (1-2), 170-178, 2012
242012
Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody …
A Adhikari, CN Teijaro, X Yan, CY Chang, C Gui, YC Liu, I Crnovcic, ...
Journal of medicinal chemistry 63 (15), 8432-8441, 2020
192020
Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes
KC Wang, SY Lyu, YC Liu, CY Chang, CJ Wu, TL Li
Acta Crystallographica Section D: Biological Crystallography 70 (5), 1401-1410, 2014
192014
Chain elongation and cyclization in type III PKS DpgA
HC Wu, YS Li, YC Liu, SY Lyu, CJ Wu, TL Li
ChemBioChem 13 (6), 862-871, 2012
142012
Cryptic sulfur incorporation in thioangucycline biosynthesis
M Cao, C Zheng, D Yang, E Kalkreuter, A Adhikari, YC Liu, ME Rateb, ...
Angewandte Chemie 133 (13), 7216-7223, 2021
132021
The Mesomeric Effect of Thiazolium on non‐Kekulé Diradicals in Pichia stipitis Transketolase
NS Hsu, YL Wang, KH Lin, CF Chang, SY Lyu, LJ Hsu, YC Liu, CY Chang, ...
Angewandte Chemie International Edition 57 (7), 1802-1807, 2018
62018
PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases
CJ Zheng, E Kalkreuter, BY Fan, YC Liu, LB Dong, B Shen
ACS chemical biology 16 (1), 96-105, 2020
52020
Structural and mechanistic basis for novel compound biosynthesis using the 4-electron hexose oxidase
TL Li, YC Liu, YS Li, SY Lyu
US Patent 8,507,427, 2013
32013
Addendum: Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds
YC Liu, YS Li, SY Lyu, LJ Hsu, YH Chen, YT Huang, HC Chan, CJ Huang, ...
Nature Chemical Biology 11 (5), 361-361, 2015
22015
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