Structure and mechanism of assembly line polyketide synthases T Robbins, YC Liu, DE Cane, C Khosla Current opinion in structural biology 41, 10-18, 2016 | 152 | 2016 |
Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds YC Liu, YS Li, SY Lyu, LJ Hsu, YH Chen, YT Huang, HC Chan, CJ Huang, ... Nature Chemical Biology 7 (5), 304-309, 2011 | 61 | 2011 |
Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms CY Chang, SY Lyu, YC Liu, NS Hsu, CC Wu, CF Tang, KH Lin, JY Ho, ... Angewandte Chemie 126 (7), 1974-1979, 2014 | 56 | 2014 |
In vitro Characterization of Enzymes Involved in the Synthesis of Nonproteinogenic Residue (2S,3S)‐β‐Methylphenylalanine in Glycopeptide Antibiotic … YT Huang, SY Lyu, PH Chuang, NS Hsu, YS Li, HC Chan, CJ Huang, ... Chembiochem 10 (15), 2480-2487, 2009 | 48 | 2009 |
Solution structure of γ‐bungarotoxin: the functional significance of amino acid residues flanking the RGD motif in integrin binding JH Shiu, CY Chen, LS Chang, YC Chen, YC Chen, YH Lo, YC Liu, ... Proteins: Structure, Function, and Bioinformatics 57 (4), 839-849, 2004 | 42 | 2004 |
Structure–function analysis of the extended conformation of a polyketide synthase module X Li, N Sevillano, F La Greca, L Deis, YC Liu, MC Deller, II Mathews, ... Journal of the American Chemical Society 140 (21), 6518-6521, 2018 | 41 | 2018 |
Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase XW Zou, YC Liu, NS Hsu, CJ Huang, SY Lyu, HC Chan, CY Chang, ... Acta Crystallographica Section D: Biological Crystallography 70 (6), 1549-1560, 2014 | 34 | 2014 |
Regioselective deacetylation based on teicoplanin-complexed Orf2* crystal structures HC Chan, YT Huang, SY Lyu, CJ Huang, YS Li, YC Liu, CC Chou, ... Molecular BioSystems 7 (4), 1224-1231, 2011 | 28 | 2011 |
Characterization and crystal structure of a nonheme diiron monooxygenase involved in platensimycin and platencin biosynthesis LB Dong, YC Liu, AJ Cepeda, E Kalkreuter, MR Deng, JD Rudolf, ... Journal of the American Chemical Society 141 (31), 12406-12412, 2019 | 27 | 2019 |
Multiple Complexes of Long Aliphatic N-Acyltransferases Lead to Synthesis of 2,6-Diacylated/2-Acyl-Substituted Glycopeptide Antibiotics, Effectively Killing … SY Lyu, YC Liu, CY Chang, CJ Huang, YH Chiu, CM Huang, NS Hsu, ... Journal of the American Chemical Society 136 (31), 10989-10995, 2014 | 25 | 2014 |
Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: Importance of the interactions between the D residue and integrin CY Chen, JH Shiu, YH Hsieh, YC Liu, YC Chen, YC Chen, WY Jeng, ... Proteins: Structure, Function, and Bioinformatics 76 (4), 808-821, 2009 | 25 | 2009 |
Combining biocatalysis and chemoselective chemistries for glycopeptide antibiotics modification TL Li, YC Liu, SY Lyu Current Opinion in Chemical Biology 16 (1-2), 170-178, 2012 | 24 | 2012 |
Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody … A Adhikari, CN Teijaro, X Yan, CY Chang, C Gui, YC Liu, I Crnovcic, ... Journal of medicinal chemistry 63 (15), 8432-8441, 2020 | 19 | 2020 |
Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes KC Wang, SY Lyu, YC Liu, CY Chang, CJ Wu, TL Li Acta Crystallographica Section D: Biological Crystallography 70 (5), 1401-1410, 2014 | 19 | 2014 |
Chain elongation and cyclization in type III PKS DpgA HC Wu, YS Li, YC Liu, SY Lyu, CJ Wu, TL Li ChemBioChem 13 (6), 862-871, 2012 | 14 | 2012 |
Cryptic sulfur incorporation in thioangucycline biosynthesis M Cao, C Zheng, D Yang, E Kalkreuter, A Adhikari, YC Liu, ME Rateb, ... Angewandte Chemie 133 (13), 7216-7223, 2021 | 13 | 2021 |
The Mesomeric Effect of Thiazolium on non‐Kekulé Diradicals in Pichia stipitis Transketolase NS Hsu, YL Wang, KH Lin, CF Chang, SY Lyu, LJ Hsu, YC Liu, CY Chang, ... Angewandte Chemie International Edition 57 (7), 1802-1807, 2018 | 6 | 2018 |
PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases CJ Zheng, E Kalkreuter, BY Fan, YC Liu, LB Dong, B Shen ACS chemical biology 16 (1), 96-105, 2020 | 5 | 2020 |
Structural and mechanistic basis for novel compound biosynthesis using the 4-electron hexose oxidase TL Li, YC Liu, YS Li, SY Lyu US Patent 8,507,427, 2013 | 3 | 2013 |
Addendum: Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds YC Liu, YS Li, SY Lyu, LJ Hsu, YH Chen, YT Huang, HC Chan, CJ Huang, ... Nature Chemical Biology 11 (5), 361-361, 2015 | 2 | 2015 |