Dipak Patil
Dipak Patil
Senior Scientist
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Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans
K Lohmann, I Masuho, DN Patil, H Baumann, E Hebert, S Steinrücke, ...
Human molecular genetics 26 (6), 1078-1086, 2017
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
BS Muntean, I Masuho, M Dao, LP Sutton, S Zucca, H Iwamoto, DN Patil, ...
Cell reports 34 (5), 2021
Lipid binding promotes oligomerization and focal adhesion activity of vinculin
K Chinthalapudi, ES Rangarajan, DN Patil, EM George, DT Brown, T Izard
Journal of Cell Biology 207 (5), 643-656, 2014
Structural and functional evolution of chitinase‐like proteins from plants
P Kesari, DN Patil, P Kumar, S Tomar, AK Sharma, P Kumar
Proteomics 15 (10), 1693-1705, 2015
Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans
HA Dunn, DN Patil, Y Cao, C Orlandi, KA Martemyanov
Proceedings of the National Academy of Sciences 115 (19), 5022-5027, 2018
GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition
HE Shamseldin, I Masuho, A Alenizi, S Alyamani, DN Patil, N Ibrahim, ...
Genome biology 17, 1-9, 2016
Structural basis for dual inhibitory role of tamarind K unitz inhibitor (TKI) against factor X a and trypsin
DN Patil, A Chaudhary, AK Sharma, S Tomar, P Kumar
The FEBS Journal 279 (24), 4547-4564, 2012
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex
DN Patil, S Singh, T Laboute, TS Strutzenberg, X Qiu, D Wu, SJ Novick, ...
Science 375 (6576), 86-91, 2022
Structure-function studies of DNA binding domain of response regulator KdpE reveals equal affinity interactions at DNA half-sites
A Narayanan, LN Paul, S Tomar, DN Patil, P Kumar, DA Yernool
PloS one 7 (1), e30102, 2012
Biochemical studies and ligand-bound structures of biphenyl dehydrogenase from Pandoraea pnomenusa strain B-356 reveal a basis for broad specificity of the enzyme
S Dhindwal, DN Patil, M Mohammadi, M Sylvestre, S Tomar, P Kumar
Journal of Biological Chemistry 286 (42), 37011-37022, 2011
Isolation, purification, crystallization and preliminary crystallographic studies of chitinase from tamarind (Tamarindus indica) seeds
DN Patil, M Datta, A Chaudhary, S Tomar, A Kumar Sharma, P Kumar
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2009
Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex
DN Patil, ES Rangarajan, SJ Novick, BD Pascal, DJ Kojetin, PR Griffin, ...
Elife 7, e42150, 2018
Structural investigation of a novel N-acetyl glucosamine binding chi-lectin which reveals evolutionary relationship with class III chitinases
DN Patil, M Datta, A Dev, S Dhindwal, N Singh, P Dasauni, S Kundu, ...
PLoS One 8 (5), e63779, 2013
Lipid-directed vinculin dimerization
K Chinthalapudi, DN Patil, ES Rangarajan, C Rader, T Izard
Biochemistry 54 (17), 2758-2768, 2015
Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR
T Laboute, S Zucca, M Holcomb, DN Patil, C Garza, BA Wheatley, RN Roy, ...
Science 379 (6639), 1352-1358, 2023
Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling
I Masuho, S Chavali, BS Muntean, NK Skamangas, K Simonyan, DN Patil, ...
Cell Reports 24 (3), 557-568. e5, 2018
Conformational flexibility determines the Nf2/merlin tumor suppressor functions
MC Primi, ES Rangarajan, DN Patil, T Izard
Matrix Biology Plus 12, 100074, 2021
Purification, crystallization and preliminary crystallographic studies of a Kunitz-type proteinase inhibitor from tamarind (Tamarindus indica) seeds
DN Patil, A Chaudhry, AK Sharma, S Tomar, P Kumar
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2009
Purification and biophysical characterization of an 11S globulin from Wrightia tinctoria exhibiting hemagglutinating activity
P Kumar, D N Patil, A Chaudhary, S Tomar, D Yernool, N Singh, ...
Protein and Peptide Letters 20 (5), 499-509, 2013
Crystallization and preliminary X-ray diffraction analysis of the complex of Kunitz-type tamarind trypsin inhibitor and porcine pancreatic trypsin
S Tomar, DN Patil, M Datta, S Tapas, A Chaudhary, AK Sharma, P Kumar
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2009
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