Ken Westover
Ken Westover
Associate Professor of Biochemistry and Radiation Oncology, UT Southwestern
Verified email at - Homepage
Cited by
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Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
M Taipale, I Krykbaeva, M Koeva, C Kayatekin, KD Westover, GI Karras, ...
Cell 150 (5), 987-1001, 2012
Consolidative radiotherapy for limited metastatic non–small-cell lung cancer: a phase 2 randomized clinical trial
P Iyengar, Z Wardak, DE Gerber, V Tumati, C Ahn, RS Hughes, JE Dowell, ...
JAMA oncology 4 (1), e173501-e173501, 2018
The molecular basis of eukaryotic transcription
RD Kornberg
Proceedings of the National Academy of Sciences 104 (32), 12955-12961, 2007
Biochemical and structural analysis of common cancer-associated KRAS mutations
JC Hunter, A Manandhar, MA Carrasco, D Gurbani, S Gondi, ...
Molecular cancer research 13 (9), 1325-1335, 2015
Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
D Wang, DA Bushnell, KD Westover, CD Kaplan, RD Kornberg
Cell 127 (5), 941-954, 2006
Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms
DA Bushnell, KD Westover, RE Davis, RD Kornberg
Science 303 (5660), 983-988, 2004
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
ME Pacold, KR Brimacombe, SH Chan, JM Rohde, CA Lewis, ...
Nature chemical biology 12 (6), 452-458, 2016
Therapeutic targeting of oncogenic K‐Ras by a covalent catalytic site inhibitor
SM Lim, KD Westover, SB Ficarro, RA Harrison, HG Choi, ME Pacold, ...
Angewandte Chemie International Edition 53 (1), 199-204, 2014
Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center
KD Westover, DA Bushnell, RD Kornberg
Cell 119 (4), 481-489, 2004
Structural basis of transcription: separation of RNA from DNA by RNA polymerase II
KD Westover, DA Bushnell, RD Kornberg
Science 303 (5660), 1014-1016, 2004
Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution
D Wang, DA Bushnell, X Huang, KD Westover, M Levitt, RD Kornberg
Science 324 (5931), 1203-1206, 2009
KRAS dimerization impacts MEK inhibitor sensitivity and oncogenic activity of mutant KRAS
C Ambrogio, J Köhler, ZW Zhou, H Wang, R Paranal, J Li, M Capelletti, ...
Cell 172 (4), 857-868. e15, 2018
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
JC Hunter, D Gurbani, SB Ficarro, MA Carrasco, SM Lim, HG Choi, T Xie, ...
Proceedings of the National Academy of Sciences 111 (24), 8895-8900, 2014
Structural basis of eukaryotic gene transcription
H Boeger, DA Bushnell, R Davis, J Griesenbeck, Y Lorch, JS Strattan, ...
FEBS letters 579 (4), 899-903, 2005
Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATRPIKK Inhibitor Torin2 with Antitumor Activity
Q Liu, C Xu, S Kirubakaran, X Zhang, W Hur, Y Liu, NP Kwiatkowski, ...
Cancer research 73 (8), 2574-2586, 2013
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease
J Ye, UP Davé, NV Grishin, JL Goldstein, MS Brown
Proceedings of the National Academy of Sciences 97 (10), 5123-5128, 2000
Pharmacological targeting of the pseudokinase Her3
T Xie, SM Lim, KD Westover, ME Dodge, D Ercan, SB Ficarro, ...
Nature chemical biology 10 (12), 1006-1012, 2014
Neutrophil–lymphocyte and platelet–lymphocyte ratios as prognostic factors after stereotactic radiation therapy for early-stage non–small-cell lung cancer
NA Cannon, J Meyer, P Iyengar, C Ahn, KD Westover, H Choy, ...
Journal of Thoracic Oncology 10 (2), 280-285, 2015
Exploring targeted degradation strategy for oncogenic KRASG12C
M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ...
Cell chemical biology 27 (1), 19-31. e6, 2020
Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex
JS Anant, L Desnoyers, M Machius, B Demeler, JC Hansen, KD Westover, ...
Biochemistry 37 (36), 12559-12568, 1998
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