| Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture N Reixach, S Deechongkit, X Jiang, JW Kelly, JN Buxbaum Proceedings of the National Academy of Sciences 101 (9), 2817-2822, 2004 | 458 | 2004 |
| Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Aβ toxicity JN Buxbaum, Z Ye, N Reixach, L Friske, C Levy, P Das, T Golde, ... Proceedings of the National Academy of Sciences 105 (7), 2681-2686, 2008 | 333 | 2008 |
| Transthyretin: the servant of many masters JN Buxbaum, N Reixach Cellular and molecular life sciences 66, 3095-3101, 2009 | 233 | 2009 |
| AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin SC Penchala, S Connelly, Y Wang, MS Park, L Zhao, A Baranczak, ... Proceedings of the National Academy of Sciences 110 (24), 9992-9997, 2013 | 164 | 2013 |
| Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity R Sant'Anna, P Gallego, LZ Robinson, A Pereira-Henriques, N Ferreira, ... Nature communications 7 (1), 10787, 2016 | 157 | 2016 |
| Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective? X Li, E Masliah, N Reixach, JN Buxbaum Journal of Neuroscience 31 (35), 12483-12490, 2011 | 140 | 2011 |
| Age-related oxidative modifications of transthyretin modulate its amyloidogenicity L Zhao, JN Buxbaum, N Reixach Biochemistry 52 (11), 1913-1926, 2013 | 128 | 2013 |
| Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion S Bourgault, JP Solomon, N Reixach, JW Kelly Biochemistry 50 (6), 1001-1015, 2011 | 120 | 2011 |
| Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs S Bourgault, S Choi, JN Buxbaum, JW Kelly, JL Price, N Reixach Biochemical and biophysical research communications 410 (4), 707-713, 2011 | 109 | 2011 |
| Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma S Choi, S Connelly, N Reixach, IA Wilson, JW Kelly Nature chemical biology 6 (2), 133-139, 2010 | 106 | 2010 |
| Poly‐(L‐alanine) expansions form core β‐sheets that nucleate amyloid assembly LM Shinchuk, D Sharma, SE Blondelle, N Reixach, H Inouye, ... Proteins: Structure, Function, and Bioinformatics 61 (3), 579-589, 2005 | 97 | 2005 |
| Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity MM Alhamadsheh, S Connelly, A Cho, N Reixach, ET Powers, DW Pan, ... Science translational medicine 3 (97), 97ra81-97ra81, 2011 | 95 | 2011 |
| A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity S Choi, N Reixach, S Connelly, SM Johnson, IA Wilson, JW Kelly Journal of the American Chemical Society 132 (4), 1359-1370, 2010 | 73 | 2010 |
| The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease … X Wang, F Cattaneo, L Ryno, J Hulleman, N Reixach, JN Buxbaum Journal of Neuroscience 34 (21), 7253-7265, 2014 | 65 | 2014 |
| Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic: a lesson in the generation of transgenic models of diseases involving oligomeric proteins N Reixach, TR Foss, E Santelli, J Pascual, JW Kelly, JN Buxbaum Journal of biological chemistry 283 (4), 2098-2107, 2008 | 59 | 2008 |
| Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis Y Akasaki, N Reixach, T Matsuzaki, O Alvarez‐Garcia, M Olmer, ... Arthritis & Rheumatology 67 (8), 2097-2107, 2015 | 50 | 2015 |
| Oxidation inhibits amyloid fibril formation of transthyretin SD Maleknia, N Reixach, JN Buxbaum The FEBS journal 273 (23), 5400-5406, 2006 | 50 | 2006 |
| Cell based screening of inhibitors of transthyretin aggregation N Reixach, SL Adamski-Werner, JW Kelly, J Koziol, JN Buxbaum Biochemical and biophysical research communications 348 (3), 889-897, 2006 | 48 | 2006 |
| Inhibition of β-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library N Reixach, E Crooks, JM Ostresh, RA Houghten, SE Blondelle Journal of Structural Biology 130 (2-3), 247-258, 2000 | 46 | 2000 |
| Inhibition of β-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library N Reixach, E Crooks, JM Ostresh, RA Houghten, SE Blondelle Journal of Structural Biology 130 (2-3), 247-258, 2000 | 46 | 2000 |
Stephen Connelly B.Sc., Ph.D.,The Scripps Research InstituteVerified email at scripps.edu
