| Drug repurposing: progress, challenges and recommendations S Pushpakom, F Iorio, PA Eyers, KJ Escott, S Hopper, A Wells, A Doig, ... Nature reviews Drug discovery 18 (1), 41-58, 2019 | 3785 | 2019 |
| Distinguishing enzyme structures from non-enzymes without alignments PD Dobson, AJ Doig Journal of molecular biology 330 (4), 771-783, 2003 | 749 | 2003 |
| Amyloid β protein and Alzheimer’s disease: When computer simulations complement experimental studies J Nasica-Labouze, PH Nguyen, F Sterpone, O Berthoumieu, NV Buchete, ... Chemical reviews 115 (9), 3518-3563, 2015 | 624 | 2015 |
| Amyloid oligomers: A joint experimental/computational perspective on Alzheimer’s disease, Parkinson’s disease, type II diabetes, and amyotrophic lateral sclerosis PH Nguyen, A Ramamoorthy, BR Sahoo, J Zheng, P Faller, JE Straub, ... Chemical reviews 121 (4), 2545-2647, 2021 | 503 | 2021 |
| N‐and C‐capping preferences for all 20 amino acids in α‐helical peptides AJ Doig, RL Baldwin Protein Science 4 (7), 1325-1336, 1995 | 457 | 1995 |
| Side‐chain conformational entropy in protein folding AJ Doig, MJE Sternberg Protein Science 4 (11), 2247-2251, 1995 | 386 | 1995 |
| Properties and identification of human protein drug targets TM Bakheet, AJ Doig Bioinformatics 25 (4), 451-457, 2009 | 341 | 2009 |
| Inhibition of toxicity in the β-amyloid peptide fragment β-(25–35) using N-methylated derivatives: a general strategy to prevent amyloid formation E Hughes, RM Burke, AJ Doig Journal of Biological Chemistry 275 (33), 25109-25115, 2000 | 308 | 2000 |
| Inhibition of protein aggregation and amyloid formation by small molecules AJ Doig, P Derreumaux Current opinion in structural biology 30, 50-56, 2015 | 306 | 2015 |
| Helix capping propensities in peptides parallel those in proteins. A Chakrabartty, AJ Doig, RL Baldwin Proceedings of the National Academy of Sciences 90 (23), 11332-11336, 1993 | 306 | 1993 |
| Toward the semiquantitative estimation of binding constants. Guides for peptide-peptide binding in aqueous solution DH Williams, JPL Cox, AJ Doig, M Gardner, U Gerhard, PT Kaye, AR Lal, ... Journal of the American Chemical Society 113 (18), 7020-7030, 1991 | 267 | 1991 |
| Is polyproline II helix the killer conformation? A Raman optical activity study of the amyloidogenic prefibrillar intermediate of human lysozyme EW Blanch, LA Morozova-Roche, DAE Cochran, AJ Doig, L Hecht, ... Journal of Molecular Biology 301 (2), 553-563, 2000 | 262 | 2000 |
| Is the hydrophobic effect stabilizing or destabilizing in proteins?: The contribution of disulphide bonds to protein stability AJ Doig, DH Williams Journal of molecular biology 217 (2), 389-398, 1991 | 248 | 1991 |
| N-methylated peptide inhibitors of β-amyloid aggregation and toxicity. Optimization of the inhibitor structure N Kokkoni, K Stott, H Amijee, JM Mason, AJ Doig Biochemistry 45 (32), 9906-9918, 2006 | 244 | 2006 |
| Determination of free energies of N-Capping in. alpha.-helixes by modification of the Lifson-Roig Helix-Coil theory to include N-and C-Capping AJ Doig, A Chakrabartty, TM Klingler, RL Baldwin Biochemistry 33 (11), 3396-3403, 1994 | 236 | 1994 |
| Predicting enzyme class from protein structure without alignments PD Dobson, AJ Doig Journal of molecular biology 345 (1), 187-199, 2005 | 211 | 2005 |
| Why is research on amyloid-β failing to give new drugs for Alzheimer’s disease? AJ Doig, MP del Castillo-Frias, O Berthoumieu, B Tarus, ... ACS chemical neuroscience 8 (7), 1435-1437, 2017 | 206 | 2017 |
| Design strategies for anti-amyloid agents JM Mason, N Kokkoni, K Stott, AJ Doig Current opinion in structural biology 13 (4), 526-532, 2003 | 167 | 2003 |
| Properties of protein drug target classes SC Bull, AJ Doig PloS one 10 (3), e0117955, 2015 | 159 | 2015 |
| Effect of phosphorylation on α-helix stability as a function of position CD Andrew, J Warwicker, GR Jones, AJ Doig Biochemistry 41 (6), 1897-1905, 2002 | 155 | 2002 |
