| Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation P Jaakkola, DR Mole, YM Tian, MI Wilson, J Gielbert, SJ Gaskell, ... Science 292 (5516), 468-472, 2001 | 6250 | 2001 |
| C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation ACR Epstein, JM Gleadle, LA McNeill, KS Hewitson, J O'Rourke, DR Mole, ... Cell 107 (1), 43-54, 2001 | 3871 | 2001 |
| Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein ME Cockman, N Masson, DR Mole, P Jaakkola, GW Chang, SC Clifford, ... Journal of Biological Chemistry 275 (33), 25733-25741, 2000 | 1358 | 2000 |
| HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability JS Isaacs, YJ Jung, DR Mole, S Lee, C Torres-Cabala, YL Chung, ... Cancer cell 8 (2), 143-153, 2005 | 1018 | 2005 |
| High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq J Schödel, S Oikonomopoulos, J Ragoussis, CW Pugh, PJ Ratcliffe, ... Blood, The Journal of the American Society of Hematology 117 (23), e207-e217, 2011 | 757 | 2011 |
| Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts DR Mole, C Blancher, RR Copley, PJ Pollard, JM Gleadle, J Ragoussis, ... Journal of biological chemistry 284 (25), 16767-16775, 2009 | 657 | 2009 |
| Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia SO Ang, H Chen, K Hirota, VR Gordeuk, J Jelinek, Y Guan, E Liu, ... Nature genetics 32 (4), 614-621, 2002 | 583 | 2002 |
| Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease SC Clifford, ME Cockman, AC Smallwood, DR Mole, ER Woodward, ... Human molecular genetics 10 (10), 1029-1038, 2001 | 444 | 2001 |
| Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival H Choudhry, A Albukhari, M Morotti, S Haider, D Moralli, J Smythies, ... Oncogene 34 (34), 4482-4490, 2015 | 320 | 2015 |
| Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α PJ Pollard, C Loenarz, DR Mole, MA McDonough, JM Gleadle, ... Biochemical Journal 416 (3), 387-394, 2008 | 316 | 2008 |
| The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1 R Schietke, C Warnecke, I Wacker, J Schödel, DR Mole, V Campean, ... Journal of Biological Chemistry 285 (9), 6658-6669, 2010 | 278 | 2010 |
| Hypoxia, hypoxia-inducible transcription factors, and renal cancer J Schödel, S Grampp, ER Maher, H Moch, PJ Ratcliffe, P Russo, DR Mole European urology 69 (4), 646-657, 2016 | 271 | 2016 |
| 2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase DR Mole, I Schlemminger, LA McNeill, KS Hewitson, CW Pugh, ... Bioorganic & medicinal chemistry letters 13 (16), 2677-2680, 2003 | 181 | 2003 |
| Common genetic variants at the 11q13. 3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression J Schödel, C Bardella, LK Sciesielski, JM Brown, CW Pugh, V Buckle, ... Nature genetics 44 (4), 420-425, 2012 | 169 | 2012 |
| Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia C Camps, HK Saini, DR Mole, H Choudhry, M Reczko, ... Molecular cancer 13 (1), 1-21, 2014 | 163 | 2014 |
| Extensive regulation of the non‐coding transcriptome by hypoxia: role of HIF in releasing paused RNA pol2 H Choudhry, J Schödel, S Oikonomopoulos, C Camps, S Grampp, ... EMBO reports 15 (1), 70-76, 2014 | 158 | 2014 |
| miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis RI McCormick, C Blick, J Ragoussis, J Schoedel, DR Mole, AC Young, ... British journal of cancer 108 (5), 1133-1142, 2013 | 152 | 2013 |
| Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin JA Smythies, M Sun, N Masson, R Salama, PD Simpson, E Murray, ... EMBO reports 20 (1), e46401, 2019 | 149 | 2019 |
| Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis S Lakhal, J Schödel, ARM Townsend, CW Pugh, PJ Ratcliffe, DR Mole Journal of Biological Chemistry 286 (6), 4090-4097, 2011 | 146 | 2011 |
| Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α) A Thalhammer, Z Bencokova, R Poole, C Loenarz, J Adam, L O'Flaherty, ... PloS one 6 (1), e16210, 2011 | 141 | 2011 |
