| NF-κB restricts inflammasome activation via elimination of damaged mitochondria Z Zhong, A Umemura, E Sanchez-Lopez, S Liang, S Shalapour, J Wong, ... Cell 164 (5), 896-910, 2016 | 981 | 2016 |
| ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development H Nakagawa, A Umemura, K Taniguchi, J Font-Burgada, D Dhar, H Ogata, ... Cancer cell 26 (3), 331-343, 2014 | 483 | 2014 |
| Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer J Font-Burgada, S Shalapour, S Ramaswamy, B Hsueh, D Rossell, ... Cell 162 (4), 766-779, 2015 | 465 | 2015 |
| p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells A Umemura, F He, K Taniguchi, H Nakagawa, S Yamachika, ... Cancer cell 29 (6), 935-948, 2016 | 418 | 2016 |
| Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese T Kawaguchi, Y Sumida, A Umemura, K Matsuo, M Takahashi, ... PloS one 7 (6), e38322, 2012 | 289 | 2012 |
| Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition A Umemura, EJ Park, K Taniguchi, JH Lee, S Shalapour, MA Valasek, ... Cell metabolism 20 (1), 133-144, 2014 | 183 | 2014 |
| Effect of sodium glucose cotransporter 2 inhibitor on liver function tests in Japanese patients with non‐alcoholic fatty liver disease and type 2 diabetes mellitus Y Seko, Y Sumida, S Tanaka, K Mori, H Taketani, H Ishiba, T Hara, ... Hepatology Research 47 (10), 1072-1078, 2017 | 176* | 2017 |
| Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis H Nakagawa, Y Hikiba, Y Hirata, J Font-Burgada, K Sakamoto, ... Proceedings of the National Academy of Sciences 111 (3), 1090-1095, 2014 | 132 | 2014 |
| Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan T Okanoue, A Umemura, K Yasui, Y Itoh Journal of gastroenterology and hepatology 26, 153-162, 2011 | 131 | 2011 |
| Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers T Kawaguchi, T Shima, M Mizuno, Y Mitsumoto, A Umemura, Y Kanbara, ... PLoS One 13 (1), e0185490, 2018 | 120 | 2018 |
| Stress-activated NRF2-MDM2 cascade controls neoplastic progression in pancreas J Todoric, L Antonucci, G Di Caro, N Li, X Wu, NK Lytle, D Dhar, ... Cancer cell 32 (6), 824-839. e8, 2017 | 119 | 2017 |
| High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells C Yokomizo, K Yamaguchi, Y Itoh, T Nishimura, A Umemura, M Minami, ... Cancer letters 310 (2), 140-147, 2011 | 91 | 2011 |
| Efficacy and safety of canagliflozin in type 2 diabetes mellitus patients with biopsy-proven nonalcoholic steatohepatitis classified as stage 1–3 fibrosis Y Seko, T Nishikawa, A Umemura, K Yamaguchi, M Moriguchi, K Yasui, ... Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 835-843, 2018 | 89 | 2018 |
| NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly F He, L Antonucci, S Yamachika, Z Zhang, K Taniguchi, A Umemura, ... Journal of hepatology 72 (6), 1182-1195, 2020 | 87 | 2020 |
| p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species T Sakurai, M Kudo, A Umemura, G He, AM Elsharkawy, E Seki, M Karin Cancer research 73 (1), 215-224, 2013 | 83 | 2013 |
| Oncogenic miR-96-5p inhibits apoptosis by targeting the caspase-9 gene in hepatocellular carcinoma N Iwai, K Yasui, A Tomie, Y Gen, K Terasaki, T Kitaichi, T Soda, ... International journal of oncology 53 (1), 237-245, 2018 | 77 | 2018 |
| Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice K Yamaguchi, Y Itoh, C Yokomizo, T Nishimura, T Niimi, A Umemura, ... Laboratory investigation 91 (4), 609-618, 2011 | 75 | 2011 |
| Association of gankyrin protein expression with early clinical stages and insulin‐like growth factor‐binding protein 5 expression in human hepatocellular carcinoma A Umemura, Y Itoh, K Itoh, K Yamaguchi, T Nakajima, H Higashitsuji, ... Hepatology 47 (2), 493-502, 2008 | 73 | 2008 |
| Development of hepatocellular carcinoma in Japanese patients with biopsy‐proven non‐alcoholic fatty liver disease: association between PNPLA3 genotype and hepatocarcinogenesis … Y Seko, Y Sumida, S Tanaka, K Mori, H Taketani, H Ishiba, T Hara, ... Hepatology Research 47 (11), 1083-1092, 2017 | 69 | 2017 |
| Impact of relative dose intensity of early-phase lenvatinib treatment on therapeutic response in hepatocellular carcinoma AYA Takahashi, M Moriguchi, Y Seko, H Ishikawa, T Yo, H Kimura, H Fujii, ... Anticancer research 39 (9), 5149-5156, 2019 | 62 | 2019 |
