Efstratios Stratikos
Efstratios Stratikos
Associate Professor of Biochemistry, Department of Chemistry, University of Athens
Verified email at chem.uoa.gr - Homepage
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Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Ň and full insertion of the reactive center loop into β-sheet A
E Stratikos, PGW Gettins
Proceedings of the National Academy of Sciences 96 (9), 4808-4813, 1999
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1
TT Nguyen, SC Chang, I Evnouchidou, IA York, C Zikos, KL Rock, ...
Nature structural & molecular biology 18 (5), 604, 2011
Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1
S Kim, S Lee, J Shin, Y Kim, I Evnouchidou, D Kim, YK Kim, YE Kim, ...
Nature immunology 12 (10), 984-991, 2011
Major proteinase movement upon stable serpin–proteinase complex formation
E Stratikos, PGW Gettins
Proceedings of the National Academy of Sciences 94 (2), 453-458, 1997
Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic†…
I Evnouchidou, RP Kamal, SS Seregin, Y Goto, M Tsujimoto, A Hattori, ...
The Journal of Immunology 186 (4), 1909-1913, 2011
The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1
I Evnouchidou, F Momburg, A Papakyriakou, A Chroni, L Leondiadis, ...
PloS one 3 (11), e3658, 2008
The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing
JR Birtley, E Saridakis, E Stratikos, IM Mavridis
Biochemistry 51 (1), 286-295, 2012
Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides
E Zervoudi, A Papakyriakou, D Georgiadou, I Evnouchidou, A Gajda, ...
Biochemical Journal 435 (2), 411-420, 2011
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses
E Zervoudi, E Saridakis, JR Birtley, SS Seregin, E Reeves, P Kokkala, ...
Proceedings of the National Academy of Sciences 110 (49), 19890-19895, 2013
Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II α-chain
E Stratikos, DC Wiley, LJ Stern
The Journal of Immunology 172 (2), 1109-1117, 2004
A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing
I Evnouchidou, J Birtley, S Seregin, A Papakyriakou, E Zervoudi, ...
The Journal of Immunology 189 (5), 2383-2392, 2012
Recombinant human pigment epithelium‐derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells
E Stratikos, E Alberdi, PGW Gettins, SP Becerra
Protein Science 5 (12), 2575-2582, 1996
Mapping the serpin-proteinase complex using single cysteine variants of α1-proteinase inhibitor Pittsburgh
E Stratikos, PGW Gettins
Journal of Biological Chemistry 273 (25), 15582-15589, 1998
Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens
SS Seregin, DPW Rastall, I Evnouchidou, CF Aylsworth, D Quiroga, ...
Autoimmunity 46 (8), 497-508, 2013
Structural basis for antigenic peptide recognition and processing by endoplasmic reticulum (ER) aminopeptidase 2
A Mpakali, P Giastas, N Mathioudakis, IM Mavridis, E Saridakis, ...
Journal of Biological Chemistry 290 (43), 26021-26032, 2015
Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced†…
E Stratikos, L Mosyak, DM Zaller, DC Wiley
The Journal of experimental medicine 196 (2), 173-183, 2002
A new role for Zn (II) aminopeptidases: antigenic peptide generation and destruction
I Evnouchidou, A Papakyriakou, E Stratikos
Current pharmaceutical design 15 (31), 3656-3670, 2009
A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition
E Stratikos, A Stamogiannos, E Zervoudi, D Fruci
Frontiers in oncology 4, 363, 2014
Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1
D Georgiadou, A Hearn, I Evnouchidou, A Chroni, L Leondiadis, IA York, ...
The Journal of Immunology 185 (3), 1584-1592, 2010
Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1
A Stamogiannos, D Koumantou, A Papakyriakou, E Stratikos
Molecular immunology 67 (2), 426-435, 2015
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