| Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs X Shen, DR Corey Nucleic acids research 46 (4), 1584-1600, 2018 | 603 | 2018 |
| Generation of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically relevant conditions: chemistry relevant to both the genotoxic … M Hoffman, A Rajapakse, X Shen, KS Gates Chemical research in toxicology 25 (8), 1609-1615, 2012 | 54 | 2012 |
| Activation of frataxin protein expression by antisense oligonucleotides targeting the mutant expanded repeat L Li, X Shen, Z Liu, M Norrbom, TP Prakash, D O'Reilly, VK Sharma, ... nucleic acid therapeutics 28 (1), 23-33, 2018 | 35 | 2018 |
| Enzyme-Activated Generation of Reactive Oxygen Species from Heterocyclic N-Oxides under Aerobic and Anaerobic Conditions and Its Relevance to Hypoxia … X Shen, KS Gates Chemical research in toxicology 32 (3), 348-361, 2019 | 28 | 2019 |
| Computer-aided de novo ligand design and docking/molecular dynamics study of vitamin D receptor agonists XL Shen, M Takimoto-Kamimura, J Wei, QZ Gao Journal of molecular modeling 18, 203-212, 2012 | 27 | 2012 |
| Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion X Shen, A Kilikevicius, D O'Reilly, TP Prakash, MJ Damha, F Rigo, ... Bioorganic & medicinal chemistry letters 28 (17), 2850-2855, 2018 | 22 | 2018 |
| Efficient electroporation of neuronal cells using synthetic oligonucleotides: identifying duplex RNA and antisense oligonucleotide activators of human frataxin expression X Shen, S Beasley, JN Putman, Y Li, TP Prakash, F Rigo, M Napierala, ... Rna 25 (9), 1118-1129, 2019 | 20 | 2019 |
| Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive … X Shen, CH Laber, U Sarkar, F Galazzi, KM Johnson, NG Mahieu, ... The Journal of organic chemistry 83 (6), 3126-3131, 2018 | 20 | 2018 |
| Isotopic Labeling Experiments That Elucidate the Mechanism of DNA Strand Cleavage by the Hypoxia-Selective Antitumor Agent 1,2,4-Benzotriazine 1,4-Di-N-oxide X Shen, A Rajapakse, F Gallazzi, V Junnotula, T Fuchs-Knotts, R Glaser, ... Chemical research in toxicology 27 (1), 111-118, 2014 | 20 | 2014 |
| Duplex RNAs and ss-siRNAs Block RNA Foci Associated with Fuchs' Endothelial Corneal Dystrophy J Hu, X Shen, F Rigo, TP Prakash, VV Mootha, DR Corey nucleic acid therapeutics 29 (2), 73-81, 2019 | 18 | 2019 |
| Generation of Reactive Oxygen Species Mediated by 1-Hydroxyphenazine, a Virulence Factor of Pseudomonas aeruginosa S Sinha, X Shen, F Gallazzi, Q Li, JW Zmijewski, JR Lancaster Jr, ... Chemical research in toxicology 28 (2), 175-181, 2015 | 14 | 2015 |
| Progress towards drug discovery for Friedreich’s Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein X Shen, J Wong, TP Prakash, F Rigo, Y Li, M Napierala, DR Corey Bioorganic & medicinal chemistry 28 (11), 115472, 2020 | 12 | 2020 |
| Targeting 3′ and 5′ untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression Y Li, J Li, J Wang, DR Lynch, X Shen, DR Corey, D Parekh, B Bhat, ... Nucleic acids research 49 (20), 11560-11574, 2021 | 10 | 2021 |
| Difficulties translating antisense-mediated activation of Frataxin expression from cell culture to mice A Kilikevicius, J Wang, X Shen, F Rigo, TP Prakash, M Napierala, ... RNA biology 19 (1), 364-372, 2022 | 4 | 2022 |
| The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders X Li, M Kheirabadi, PG Dougherty, KJ Kamer, X Shen, NL Estrella, ... Molecular Therapy-Nucleic Acids 33, 273-285, 2023 | 3 | 2023 |
| Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates J Hu, X Shen, M Kheirabadi, MD Streeter, Z Qian, VV Mootha, DR Corey ACS omega 8 (45), 42797-42802, 2023 | | 2023 |
| Compositions for delivery of antisense compounds Q Ziqing, X Li, M Kheirabadi, M Dhanabal, H Liu, X Shen, K Kamer, ... US Patent App. 17/757,421, 2023 | | 2023 |
| Antisense compounds and methods for targeting cug repeats Xiulong Shen, Ziqing Qian, Patrick Dougherty, Mahboubeh Kheirabadi, Xiang Li WO Patent WO2022271818A1, 2022 | | 2022 |
| Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity Ziqing Qian, Natarajan Sethuraman, Mahboubeh Kheirabadi, Haoming Liu ... WO Patent WO2022240721A1, 2022 | | 2022 |
| Compositions and methods for modulating tissue distribution of intracellular therapeutics Ziqing Qian, Patrick Dougherty, Mahboubeh Kheirabadi, Haoming Liu, Xiulong Shen WO Patent WO2022241408A1, 2022 | | 2022 |
David CoreyVerified email at utsouthwestern.edu
