Jason Moffat
Jason Moffat
Verified email at utoronto.ca - Homepage
TitleCited byYear
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
AE Carpenter, TR Jones, MR Lamprecht, C Clarke, IH Kang, O Friman, ...
Genome biology 7 (10), R100, 2006
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
J Moffat, DA Grueneberg, X Yang, SY Kim, AM Kloepfer, G Hinkle, ...
Cell 124 (6), 1283-1298, 2006
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1
DA Guertin, DM Stevens, CC Thoreen, AA Burds, NY Kalaany, J Moffat, ...
Developmental cell 11 (6), 859-871, 2006
Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate
G Huyer, S Liu, J Kelly, J Moffat, P Payette, B Kennedy, G Tsaprailis, ...
Journal of Biological Chemistry 272 (2), 843-851, 1997
Exploration of essential gene functions via titratable promoter alleles
S Mnaimneh, AP Davierwala, J Haynes, J Moffat, WT Peng, W Zhang, ...
Cell 118 (1), 31-44, 2004
High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities
T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ...
Cell 163 (6), 1515-1526, 2015
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia
M Škrtić, S Sriskanthadevan, B Jhas, M Gebbia, X Wang, Z Wang, ...
Cancer cell 20 (5), 674-688, 2011
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning
TR Jones, AE Carpenter, MR Lamprecht, J Moffat, SJ Silver, JK Grenier, ...
Proceedings of the National Academy of Sciences 106 (6), 1826-1831, 2009
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress
JM Tkach, A Yimit, AY Lee, M Riffle, M Costanzo, D Jaschob, JA Hendry, ...
Nature cell biology 14 (9), 966, 2012
Building mammalian signalling pathways with RNAi screens
J Moffat, DM Sabatini
Nature Reviews Molecular Cell Biology 7 (3), 177, 2006
Essential gene profiles in breast, pancreatic, and ovarian cancer cells
R Marcotte, KR Brown, F Suarez, A Sayad, K Karamboulas, ...
Cancer discovery 2 (2), 172-189, 2012
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming
H Han, M Irimia, PJ Ross, HK Sung, B Alipanahi, L David, A Golipour, ...
Nature 498 (7453), 241, 2013
A dynamic protein interaction landscape of the human centrosome-cilium interface
GD Gupta, ╔ Coyaud, J Gonšalves, BA Mojarad, Y Liu, Q Wu, ...
Cell 163 (6), 1484-1499, 2015
Yeast proteome dynamics from single cell imaging and automated analysis
YT Chong, JLY Koh, H Friesen, SK Duffy, MJ Cox, A Moses, J Moffat, ...
Cell 161 (6), 1413-1424, 2015
Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance
R Marcotte, A Sayad, KR Brown, F Sanchez-Garcia, J Reimand, M Haider, ...
Cell 164 (1-2), 293-309, 2016
A strategy for modulation of enzymes in the ubiquitin system
A Ernst, G Avvakumov, J Tong, Y Fan, Y Zhao, P Alberts, A Persaud, ...
Science 339 (6119), 590-595, 2013
Measuring error rates in genomic perturbation screens: gold standards for human functional genomics
T Hart, KR Brown, F Sircoulomb, R Rottapel, J Moffat
Molecular systems biology 10 (7), 2014
Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4
K Baetz, J Moffat, J Haynes, M Chang, B Andrews
Molecular and cellular biology 21 (19), 6515-6528, 2001
A role for the TGFβ-Par6 polarity pathway in breast cancer progression
AM Viloria-Petit, L David, JY Jia, T Erdemir, AL Bane, D Pinnaduwage, ...
Proceedings of the National Academy of Sciences 106 (33), 14028-14033, 2009
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
GW Xu, M Ali, TE Wood, D Wong, N Maclean, X Wang, M Gronda, M Skrtic, ...
Blood 115 (11), 2251-2259, 2010
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