| Bacterial cell wall assembly: still an attractive antibacterial target TDH Bugg, D Braddick, CG Dowson, DI Roper Trends in biotechnology 29 (4), 167-173, 2011 | 309 | 2011 |
| Vancomycin resistance in enterococci: reprogramming of the d-Ala–d-Ala ligases in bacterial peptidoglycan biosynthesis VL Healy, IAD Lessard, DI Roper, JR Knox, CT Walsh Chemistry & biology 7 (5), R109-R119, 2000 | 192 | 2000 |
| Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases HS Subramanya, DI Roper, Z Dauter, EJ Dodson, GJ Davies, KS Wilson, ... Biochemistry 35 (3), 792-802, 1996 | 192 | 1996 |
| Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins TDH Bugg, AJ Lloyd, DI Roper Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2006 | 166 | 2006 |
| Understanding the mechanism of ice binding by type III antifreeze proteins AA Antson, DJ Smith, DI Roper, S Lewis, LSD Caves, CS Verma, ... Journal of molecular biology 305 (4), 875-889, 2001 | 161 | 2001 |
| CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits L Meigh, SA Greenhalgh, TL Rodgers, MJ Cann, DI Roper, N Dale Elife 2, e01213, 2013 | 132 | 2013 |
| Asymmetric triplex metallohelices with high and selective activity against cancer cells AD Faulkner, RA Kaner, QMA Abdallah, G Clarkson, DJ Fox, P Gurnani, ... Nature Chemistry 6 (9), 797-803, 2014 | 117 | 2014 |
| Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis E Kuru, A Radkov, X Meng, A Egan, L Alvarez, A Dowson, G Booher, ... ACS Chemical Biology 14 (12), 2745-2756, 2019 | 114 | 2019 |
| FtsZ polymer-bundling by the Escherichia coli ZapA orthologue, YgfE, involves a conformational change in bound GTP E Small, R Marrington, A Rodger, DJ Scott, K Sloan, D Roper, TR Dafforn, ... Journal of molecular biology 369 (1), 210-221, 2007 | 112 | 2007 |
| The physico-chemical characterization of a boiling stable antifreeze protein from a perennial grass (Lolium perenne) PDA Pudney, SL Buckley, CM Sidebottom, SN Twigg, MP Sevilla, CB Holt, ... Archives of Biochemistry and Biophysics 410 (2), 238-245, 2003 | 112 | 2003 |
| IFN-γ enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2 S Tötemeyer, M Sheppard, A Lloyd, D Roper, C Dowson, D Underhill, ... The Journal of Immunology 176 (8), 4804-4810, 2006 | 109 | 2006 |
| A road map for prioritizing warheads for cysteine targeting covalent inhibitors P Abranyi-Balogh, L Petri, T Imre, P Szijj, A Scarpino, M Hrast, A Mitrović, ... European journal of medicinal chemistry 160, 94-107, 2018 | 108 | 2018 |
| Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics H Kishida, S Unzai, DI Roper, A Lloyd, SY Park, JRH Tame Biochemistry 45 (3), 783-792, 2006 | 105 | 2006 |
| In vitro Reconstitution of Peptidoglycan Assembly from the Gram-Positive Pathogen Streptococcus pneumoniae A Zapun, J Philippe, KA Abrahams, L Signor, DI Roper, E Breukink, ... ACS chemical biology 8 (12), 2688-2696, 2013 | 96 | 2013 |
| Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan AJ Lloyd, AM Gilbey, AM Blewett, G De Pascale, A El Zoeiby, ... Journal of biological chemistry 283 (10), 6402-6417, 2008 | 96 | 2008 |
| Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing ES Lysenko, TB Clarke, M Shchepetov, AJ Ratner, DI Roper, CG Dowson, ... PLoS pathogens 3 (8), e118, 2007 | 92 | 2007 |
| The molecular basis of vancomycin resistance in clinically relevant Enterococci: Crystal structure of d-alanyl-d-lactate ligase (VanA) DI Roper, T Huyton, A Vagin, G Dodson Proceedings of the National Academy of Sciences 97 (16), 8921-8925, 2000 | 92 | 2000 |
| The Escherichia coli C homoprotocatechuate degradative operon: hpc gene order, direction of transcription and control of expression DI Roper, T Fawcett, RA Cooper Molecular and General Genetics MGG 237, 241-250, 1993 | 89 | 1993 |
| Analysis of SMALP co-extracted phospholipids shows distinct membrane environments for three classes of bacterial membrane protein ACK Teo, SC Lee, NL Pollock, Z Stroud, S Hall, A Thakker, AR Pitt, ... Scientific Reports 9 (1), 1813, 2019 | 87 | 2019 |
| Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a S Paulin, M Jamshad, TR Dafforn, J Garcia-Lara, SJ Foster, NF Galley, ... Nanotechnology 25 (28), 285101, 2014 | 83 | 2014 |
Christopher G DowsonProfessor of Microbiology, University of WarwickVerified email at warwick.ac.uk
