| A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia L Ivanciu, R Toso, P Margaritis, G Pavani, H Kim, A Schlachterman, JH Liu, ... Nature biotechnology 29 (11), 1028-1033, 2011 | 100 | 2011 |
| Successful treatment of canine hemophilia by continuous expression of canine FVIIa P Margaritis, E Roy, MN Aljamali, HD Downey, U Giger, S Zhou, ... Blood 113 (16), 3682-3689, 2009 | 95 | 2009 |
| Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII P Margaritis, VR Arruda, M Aljamali, RM Camire, A Schlachterman, ... Journal of Clinical Investigation 113 (7), 1025, 2004 | 83 | 2004 |
| Research Report Optimized Production of High-Titer Recombinant Adeno-Associated Virus in Roller Bottles YL Liu, K Wagner, N Robinson, D Sabatino, P Margaritis, W Xiao, ... Biotechniques 34 (1), 184-189, 2003 | 83 | 2003 |
| Long-Term Expression of Human Clotting Factor IX from Retrovirally Transduced Primary Human Keratinocytes In Vivo SJ White, SM Page, P Margaritis, GG Brownlee Human gene therapy 9 (8), 1187-1195, 1998 | 76 | 1998 |
| A novel missense mutation responsible for factor VII deficiency in research Beagle colonies MB Callan, MN Aljamali, P Margaritis, ME GRIOT‐WENK, ES Pollak, ... Journal of Thrombosis and Haemostasis 4 (12), 2616-2622, 2006 | 67 | 2006 |
| An engineered U1 small nuclear RNA rescues splicing‐defective coagulation F7 gene expression in mice D Balestra, A Faella, P Margaritis, N Cavallari, F Pagani, F Bernardi, ... Journal of Thrombosis and Haemostasis 12 (2), 177-185, 2014 | 51 | 2014 |
| A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin C Yang, J Feng, W Song, J Wang, B Tsai, Y Zhang, WA Scaringe, KA Hill, ... Proceedings of the National Academy of Sciences 104 (39), 15394-15399, 2007 | 49 | 2007 |
| Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality MN Aljamali, P Margaritis, A Schlachterman, SJ Tai, E Roy, R Bunte, ... The Journal of clinical investigation 118 (5), 1825-1834, 2008 | 48 | 2008 |
| A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X SJ Tai, RW Herzog, P Margaritis, VR Arruda, K Chu, JA Golden, ... Journal of Thrombosis and Haemostasis 6 (2), 339-345, 2008 | 35 | 2008 |
| The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo G Pavani, L Ivanciu, A Faella, OA Marcos-Contreras, P Margaritis Blood 124 (7), 1157-1165, 2014 | 30 | 2014 |
| Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII OA Marcos-Contreras, SM Smith, DA Bellinger, RA Raymer, E Merricks, ... Blood 127 (5), 565-571, 2016 | 29 | 2016 |
| Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B TC Nichols, RA Raymer, HWG Franck, EP Merricks, DA Bellinger, ... Haemophilia 16 (s3), 19-23, 2010 | 29 | 2010 |
| Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo P Margaritis, E Roy, A Faella, HD Downey, L Ivanciu, G Pavani, S Zhou, ... Blood 117 (15), 3974-3982, 2011 | 21 | 2011 |
| Cellular Localization and Characterization of Cytosolic Binding Partners for Gla Domain-containing Proteins PRRG4 and PRRG2 MN Yazicioglu, L Monaldini, K Chu, FR Khazi, SL Murphy, H Huang, ... Journal of Biological Chemistry 288 (36), 25908-25914, 2013 | 17 | 2013 |
| Gene therapy in haemophilia–going for cure? P Margaritis, KA High Haemophilia 16 (s3), 24-28, 2010 | 15 | 2010 |
| Modified blood clotting factors and methods of use K High, P Margaritis, R Camire US Patent App. 09/816,688, 2001 | 14 | 2001 |
| ARFI Ultrasound Monitoring of Hemorrhage and Hemostasis In Vivo in Canine Von Willebrand Disease and Hemophilia MR Scola, TC Nichols, H Zhu, MC Caughey, EP Merricks, RA Raymer, ... Ultrasound in medicine & biology 37 (12), 2126-2132, 2011 | 13 | 2011 |
| PheWAS uncovers a pathological role of coagulation Factor X during Acinetobacter baumannii infection JE Choby, AJ Monteith, LE Himmel, P Margaritis, JK Shirey-Rice, ... Infection and immunity, IAI. 00031-19, 2019 | 9* | 2019 |
| Mutation in the factor VII hepatocyte nuclear factor 4α-binding site contributes to factor VII deficiency XW Zheng, R Kudaravalli, TT Russell, DM DiMichele, C Gibb, JE Russell, ... Blood Coagulation & Fibrinolysis 22 (7), 624-627, 2011 | 9 | 2011 |
