Lewis Cantley

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John AsaraAssociate Professor Medicine, Harvard Medical School; Director, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
Costas LyssiotisAssociate Professor of Physiology, University of MichiganVerified email at lyssiotis.com
Ji LuoNational Cancer InstituteVerified email at nih.gov
Alex TokerVerified email at bidmc.harvard.edu
David FrumanProfessor of Molecular Biology & Biochemistry, UC IrvineVerified email at uci.edu
John BlenisProfessor of Pharmacology, Weill Cornell MedicineVerified email at med.cornell.edu
Jason LocasaleDuke UniversityVerified email at alum.mit.edu
Brendan D. ManningHarvard UniversityVerified email at hsph.harvard.edu
Lucia Rameh PlantVanderbilt UniversityVerified email at vanderbilt.edu
C. Ronald KahnJoslin Diabetes Center and Harvard Medical SchoolVerified email at joslin.harvard.edu
Reuben ShawThe Salk Institute of Biological StudiesVerified email at salk.edu
Pier Paolo PandolfiDirector, Cancer Center and Cancer Research Institute, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
David R. KaplanHospital for Sick ChildrenVerified email at sickkids.ca
Ronald A. DePinhoMD AndersonVerified email at mdanderson.org
Steven ShoelsonHarvard Medical SchoolVerified email at joslin.harvard.edu
Gerburg WulfAssociate Professor in Medicine, Harvard Medical SchoolVerified email at bidmc.harvard.edu
Pasi JanneDana Farber Cancer InstituteVerified email at dfci.harvard.edu
Malcolm WhitmanHarvardVerified email at hms.harvard.edu
Kurt AugerGlaxoSmithKlineVerified email at gsk.com
Thomas RobertsProfessor, Harvard Medical SchoolVerified email at dfci.harvard.edu

Lewis Cantley

Dana Farber Cancer Center and Harvard Medical School

Verified email at med.cornell.edu

cancer metabolism signal transduction PI 3-Kinase Protein kinases


Title Sort by citations Sort by year Sort by title	Cited by Cited by	Year
Understanding the Warburg effect: the metabolic requirements of cell proliferation MG Vander Heiden, LC Cantley, CB Thompson science 324 (5930), 1029-1033, 2009	14359	2009
The phosphoinositide 3-kinase pathway LC Cantley Science 296 (5573), 1655-1657, 2002	6961	2002
AKT/PKB signaling: navigating downstream BD Manning, LC Cantley Cell 129 (7), 1261-1274, 2007	6826	2007
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling JA Engelman, K Zejnullahu, T Mitsudomi, Y Song, C Hyland, JO Park, ... science 316 (5827), 1039-1043, 2007	5147	2007
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ... Nature 462 (7274), 739-744, 2009	4086	2009
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism JA Engelman, J Luo, LC Cantley Nature Reviews Genetics 7 (8), 606-619, 2006	3646	2006
Oncogenes and signal transduction LC Cantley, KR Auger, C Carpenter, B Duckworth, A Graziani, R Kapeller, ... Cell 64 (2), 281-302, 1991	3507	1991
SH2 domains recognize specific phosphopeptide sequences S Zhou, SE Shoelson, M Chaudhuri, G Gish, T Pawson, WG Haser, F King, ... Cell 72 (5), 767-778, 1993	3472	1993
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth HR Christofk, MG Vander Heiden, MH Harris, A Ramanathan, ... Nature 452 (7184), 230-233, 2008	2952	2008
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway LC Cantley, BG Neel Proceedings of the National Academy of Sciences 96 (8), 4240-4245, 1999	2672	1999
Ras, PI (3) K and mTOR signalling controls tumour cell growth RJ Shaw, LC Cantley Nature 441 (7092), 424-430, 2006	2493	2006
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis GM DeNicola, FA Karreth, TJ Humpton, A Gopinathan, C Wei, K Frese, ... Nature 475 (7354), 106-109, 2011	2389*	2011
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy, RA DePinho, ... Science 310 (5754), 1642-1646, 2005	2220	2005
PI3K pathway alterations in cancer: variations on a theme TL Yuan, LC Cantley Oncogene 27 (41), 5497-5510, 2008	2203	2008
PI3K: downstream AKTion blocks apoptosis TF Franke, DR Kaplan, LC Cantley Cell 88 (4), 435-437, 1997	2138	1997
Phosphoinositide kinases DA Fruman, RE Meyers, LC Cantley Annual review of biochemistry 67 (1), 481-507, 1998	2061	1998
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress RJ Shaw, M Kosmatka, N Bardeesy, RL Hurley, LA Witters, RA DePinho, ... Proceedings of the National Academy of Sciences 101 (10), 3329-3335, 2004	2005	2004
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3, 4-bisphosphate TF Franke, DR Kaplan, LC Cantley, A Toker Science 275 (5300), 665-668, 1997	1940	1997
Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs JC Obenauer, LC Cantley, MB Yaffe Nucleic acids research 31 (13), 3635-3641, 2003	1894	2003
The structural basis for 14-3-3: phosphopeptide binding specificity MB Yaffe, K Rittinger, S Volinia, PR Caron, A Aitken, H Leffers, ... Cell 91 (7), 961-971, 1997	1887	1997

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