Donatella Tondi
Cited by
Cited by
Thymidylate synthase structure, function and implication in drug discovery
MP Costi, S Ferrari, A Venturelli, S Calo, D Tondi, D Barlocco
Current medicinal chemistry 12 (19), 2241-2258, 2005
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase
D Cardinale, G Guaitoli, D Tondi, R Luciani, S Henrich, OMH Salo-Ahen, ...
Proceedings of the National Academy of Sciences 108 (34), E542-E549, 2011
Mono-and disubstituted-3, 8-diazabicyclo [3.2. 1] octane derivatives as analgesics structurally related to epibatidine: Synthesis, activity, and modeling
D Barlocco, G Cignarella, D Tondi, P Vianello, S Villa, A Bartolini, ...
Journal of medicinal chemistry 41 (5), 674-681, 1998
Structure-based discovery and in-parallel optimization of novelcompetitive inhibitors of thymidylate synthase
D Tondi, U Slomczynska, MP Costi, DM Watterson, S Ghelli, BK Shoichet
Chemistry & biology 6 (5), 319-331, 1999
Structure-based optimization of a non-β-lactam lead results in inhibitors that do not up-regulate β-lactamase expression in cell culture
D Tondi, F Morandi, R Bonnet, MP Costi, BK Shoichet
Journal of the American Chemical Society 127 (13), 4632-4639, 2005
Inhibitors of β-lactamases and uses therefor
S Weston, B Shoichet, N University
US Patent 6,075,014, 2000
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase
D Tondi, RA Powers, E Caselli, MC Negri, J Blßzquez, MP Costi, ...
Chemistry & biology 8 (6), 593-610, 2001
Ten years with New Delhi metallo-β-lactamase-1 (NDM-1): from structural insights to inhibitor design
P Linciano, L Cendron, E Gianquinto, F Spyrakis, D Tondi
ACS infectious diseases 5 (1), 9-34, 2018
Structure-Based Design of Inhibitors Specific for Bacterial Thymidylate Synthase,
TJ Stout, D Tondi, M Rinaldi, D Barlocco, P Pecorari, DV Santi, ID Kuntz, ...
Biochemistry 38 (5), 1607-1617, 1999
Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy
A Venturelli, D Tondi, L Cancian, F Morandi, G Cannazza, B Segatore, ...
Journal of medicinal chemistry 50 (23), 5644-5654, 2007
Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors
D Tondi, S Cal˛, BK Shoichet, MP Costi
Bioorganic & medicinal chemistry letters 20 (11), 3416-3419, 2010
Structure-based studies on species-specific inhibition of thymidylate synthase
MP Costi, D Tondi, M Rinaldi, D Barlocco, P Pecorari, F Soragni, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2-3á…, 2002
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase
TA Fritz, D Tondi, JS Finer-Moore, MP Costi, RM Stroud
Chemistry & biology 8 (10), 981-995, 2001
Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative
D Tondi, A Venturelli, R Bonnet, C Pozzi, BK Shoichet, MP Costi
Journal of medicinal chemistry 57 (12), 5449-5458, 2014
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi metallo-β-lactamase-1
F Spyrakis, G Celenza, F Marcoccia, M Santucci, S Cross, P Bellio, ...
ACS medicinal chemistry letters 9 (1), 45-50, 2018
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition
PM Costi, M Rinaldi, D Tondi, P Pecorari, D Barlocco, S Ghelli, RM Stroud, ...
Journal of medicinal chemistry 42 (12), 2112-2124, 1999
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases
GCMPC Matteo Santucci, Francesca Spyrakis, Simon Cross, Antonio Quotadamo ...
Scientific Reports 7 (17716), doi:10.1038/s41598-017-17399-7, 2017
SOS response in bacteria: Inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein
P Bellio, L Di Pietro, A Mancini, M Piovano, M Nicoletti, F Brisdelli, ...
Phytomedicine 29, 11-18, 2017
Decoding the structural basis for carbapenem hydrolysis by class A β-lactamases: fishing for a pharmacophore
D Tondi, S Cross, A Venturelli, M P Costi, G Cruciani, F Spyrakis
Current drug targets 17 (9), 983-1005, 2016
The inhibition of extended spectrum β-lactamases: hits and leads.
D Farina, F Spyrakis, A Venturelli, S Cross, D Tondi, MP Costi
Current medicinal chemistry, 2014
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