Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy X Lan, DJ Jörg, FMG Cavalli, LM Richards, LV Nguyen, RJ Vanner, ... Nature 549 (7671), 227-232, 2017 | 421 | 2017 |
Quiescent Sox2+ cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma RJ Vanner, M Remke, M Gallo, HJ Selvadurai, F Coutinho, L Lee, ... Cancer cell 26 (1), 33-47, 2014 | 310 | 2014 |
A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression X Chen, S Wanggou, A Bodalia, M Zhu, W Dong, JJ Fan, WC Yin, HK Min, ... Neuron 100 (4), 799-815. e7, 2018 | 273 | 2018 |
ASCL1 reorganizes chromatin to direct neuronal fate and suppress tumorigenicity of glioblastoma stem cells NI Park, P Guilhamon, K Desai, RF McAdam, E Langille, M O’Connor, ... Cell stem cell 21 (2), 209-224. e7, 2017 | 217 | 2017 |
Genome-wide CRISPR-Cas9 screens expose genetic vulnerabilities and mechanisms of temozolomide sensitivity in glioblastoma stem cells G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ... Cell reports 27 (3), 971-986. e9, 2019 | 193 | 2019 |
Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity LM Richards, OKN Whitley, G MacLeod, FMG Cavalli, FJ Coutinho, ... Nature Cancer 2 (2), 157-173, 2021 | 178 | 2021 |
MLL5 orchestrates a cancer self-renewal state by repressing the histone variant H3. 3 and globally reorganizing chromatin M Gallo, FJ Coutinho, RJ Vanner, T Gayden, SC Mack, A Murison, ... Cancer cell 28 (6), 715-729, 2015 | 108 | 2015 |
A tumorigenic MLL-homeobox network in human glioblastoma stem cells M Gallo, J Ho, FJ Coutinho, R Vanner, L Lee, R Head, EKM Ling, ... Cancer research 73 (1), 417-427, 2013 | 98 | 2013 |
Metabolic regulation of the epigenome drives lethal infantile ependymoma KA Michealraj, SA Kumar, LJY Kim, FMG Cavalli, D Przelicki, JB Wojcik, ... Cell 181 (6), 1329-1345. e24, 2020 | 90 | 2020 |
PRMT5 inhibition disrupts splicing and stemness in glioblastoma P Sachamitr, JC Ho, FE Ciamponi, W Ba-Alawi, FJ Coutinho, ... Nature communications 12 (1), 979, 2021 | 86 | 2021 |
Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival P Guilhamon, C Chesnelong, MM Kushida, A Nikolic, D Singhal, ... Elife 10, e64090, 2021 | 59 | 2021 |
High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma MJ Johnston, A Nikolic, N Ninkovic, P Guilhamon, FMG Cavalli, ... Genome research 29 (8), 1211-1222, 2019 | 54 | 2019 |
Intratumoral genetic and functional heterogeneity in pediatric glioblastoma M Hoffman, AH Gillmor, DJ Kunz, MJ Johnston, A Nikolic, K Narta, ... Cancer research 79 (9), 2111-2123, 2019 | 42 | 2019 |
Characterization of bla SHV Genes on Plasmids from Escherichia coli and Salmonella enterica Isolates from Canadian Food Animals (2006-2007) JG Pouget, FJ Coutinho, RJ Reid-Smith, P Boerlin Applied and environmental microbiology 79 (12), 3864-3866, 2013 | 31 | 2013 |
Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas K Isaev, L Jiang, S Wu, CA Lee, V Watters, V Fort, R Tsai, FJ Coutinho, ... Cell Reports 37 (3), 2021 | 15 | 2021 |
A comparison of data integration methods for single-cell RNA sequencing of cancer samples LM Richards, M Riverin, S Mohanraj, S Ayyadhury, DC Croucher, ... bioRxiv, 2021.08. 04.453579, 2021 | 7 | 2021 |
Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival P Guilhamon, M Kushida, A Nikolic, D Singhal, G MacLeod, F Cavalli, ... | 3 | 2018 |
Chromatin blueprint of glioblastoma stem cells reveals common drug candidates for distinct subtypes P Guilhamon, MM Kushida, G MacLeod, SAM Tonekaboni, FMG Cavalli, ... bioRxiv, 370726, 2018 | 3 | 2018 |
The functional genomic circuitry of human glioblastoma stem cells G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ... BioRxiv, 358432, 2018 | 3 | 2018 |
CNSC-44. BIOLOGICAL PATTERN DISCOVERY IN GLIOBLASTOMA S Ayyadhury, P Sachamitr, M Kushida, N Park, F Coutinho, O Whitley, ... Neuro-Oncology 25 (Supplement_5), v32-v33, 2023 | | 2023 |