Fiona Coutinho, PhD
Fiona Coutinho, PhD
Scientific Program Manager, The Hospital for Sick Children
Verified email at
Cited by
Cited by
Quiescent Sox2+ cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma
RJ Vanner, M Remke, M Gallo, HJ Selvadurai, F Coutinho, L Lee, ...
Cancer cell 26 (1), 33-47, 2014
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
X Lan, DJ Jörg, FMG Cavalli, LM Richards, LV Nguyen, RJ Vanner, ...
Nature 549 (7671), 227-232, 2017
ASCL1 reorganizes chromatin to direct neuronal fate and suppress tumorigenicity of glioblastoma stem cells
NI Park, P Guilhamon, K Desai, RF McAdam, E Langille, M O’Connor, ...
Cell stem cell 21 (2), 209-224. e7, 2017
MLL5 orchestrates a cancer self-renewal state by repressing the histone variant H3. 3 and globally reorganizing chromatin
M Gallo, FJ Coutinho, RJ Vanner, T Gayden, SC Mack, A Murison, ...
Cancer cell 28 (6), 715-729, 2015
A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression
X Chen, S Wanggou, A Bodalia, M Zhu, W Dong, JJ Fan, WC Yin, HK Min, ...
Neuron 100 (4), 799-815. e7, 2018
A tumorigenic MLL-homeobox network in human glioblastoma stem cells
M Gallo, J Ho, FJ Coutinho, R Vanner, L Lee, R Head, EKM Ling, ...
Cancer research 73 (1), 417-427, 2013
Genome-wide CRISPR-Cas9 screens expose genetic vulnerabilities and mechanisms of temozolomide sensitivity in glioblastoma stem cells
G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ...
Cell reports 27 (3), 971-986. e9, 2019
Metabolic regulation of the epigenome drives lethal infantile ependymoma
KA Michealraj, SA Kumar, LJY Kim, FMG Cavalli, D Przelicki, JB Wojcik, ...
Cell 181 (6), 1329-1345. e24, 2020
Characterization of bla SHV genes on plasmids from Escherichia coli and Salmonella enterica isolates from Canadian Food Animals (2006-2007)
JG Pouget, FJ Coutinho, RJ Reid-Smith, P Boerlin
Applied and environmental microbiology 79 (12), 3864-3866, 2013
High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma
MJ Johnston, A Nikolic, N Ninkovic, P Guilhamon, FMG Cavalli, ...
Genome research 29 (8), 1211-1222, 2019
Intratumoral genetic and functional heterogeneity in pediatric glioblastoma
M Hoffman, AH Gillmor, DJ Kunz, MJ Johnston, A Nikolic, K Narta, ...
Cancer research 79 (9), 2111-2123, 2019
Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
LM Richards, OKN Whitley, G MacLeod, FMG Cavalli, FJ Coutinho, ...
Nature Cancer 2 (2), 157-173, 2021
Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival
P Guilhamon, C Chesnelong, MM Kushida, A Nikolic, D Singhal, ...
Elife 10, e64090, 2021
Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival
P Guilhamon, MM Kushida, A Nikolic, D Singhal, G MacLeod, ...
BioRxiv, 370726, 2020
PRMT5 inhibition disrupts splicing and stemness in glioblastoma
P Sachamitr, JC Ho, FE Ciamponi, W Ba-Alawi, FJ Coutinho, ...
Nature communications 12 (1), 1-17, 2021
Revelation of shared transcriptional gradients in glioblastoma tumors and cultured glioma stem cells
OK Whitley, LM Richards, F Cavalli, P Guilhamon, F Coutinho, M Kushida, ...
Cancer Research 80 (16 Supplement), 5724-5724, 2020
Single-cell transcriptomics uncovers clonal heterogeneity linked to drug response and cellular phenotype in adult brain tumor stem cells
LM Richards, O Whitley, FM Cavalli, Z Safikhani, F Coutinho, ...
Cancer Research 79 (13 Supplement), 967-967, 2019
Comprehensive analysis of lncRNAs reveals candidate prognostic biomarkers in multiple cancer types
K Isaev, L Jiang, CA Lee, R Tsai, F Coutinho, PB Dirks, D Schramek, ...
bioRxiv, 861039, 2019
Data and resource sharing: Advancing our understanding of glioblastoma
HA Luchman, F Coutinho, S Weiss, P Dirks
Cancer Research 78 (13 Supplement), 3058-3058, 2018
Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma
M Hoffman, AH Gillmor, DJ Kunz, M Johnston, A Nikolic, K Narta, J King, ...
bioRxiv, 434241, 2018
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