Fiona Coutinho, PhD
Fiona Coutinho, PhD
Scientific Program Manager, The Hospital for Sick Children
Verified email at
Cited by
Cited by
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
X Lan, DJ Jörg, FMG Cavalli, LM Richards, LV Nguyen, RJ Vanner, ...
Nature 549 (7671), 227-232, 2017
Quiescent Sox2+ cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma
RJ Vanner, M Remke, M Gallo, HJ Selvadurai, F Coutinho, L Lee, ...
Cancer cell 26 (1), 33-47, 2014
ASCL1 reorganizes chromatin to direct neuronal fate and suppress tumorigenicity of glioblastoma stem cells
NI Park, P Guilhamon, K Desai, RF McAdam, E Langille, M O’Connor, ...
Cell stem cell 21 (2), 209-224. e7, 2017
A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression
X Chen, S Wanggou, A Bodalia, M Zhu, W Dong, JJ Fan, WC Yin, HK Min, ...
Neuron 100 (4), 799-815. e7, 2018
Genome-wide CRISPR-Cas9 screens expose genetic vulnerabilities and mechanisms of temozolomide sensitivity in glioblastoma stem cells
G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ...
Cell reports 27 (3), 971-986. e9, 2019
MLL5 orchestrates a cancer self-renewal state by repressing the histone variant H3. 3 and globally reorganizing chromatin
M Gallo, FJ Coutinho, RJ Vanner, T Gayden, SC Mack, A Murison, ...
Cancer cell 28 (6), 715-729, 2015
A tumorigenic MLL-homeobox network in human glioblastoma stem cells
M Gallo, J Ho, FJ Coutinho, R Vanner, L Lee, R Head, EKM Ling, ...
Cancer research 73 (1), 417-427, 2013
Metabolic regulation of the epigenome drives lethal infantile ependymoma
KA Michealraj, SA Kumar, LJY Kim, FMG Cavalli, D Przelicki, JB Wojcik, ...
Cell 181 (6), 1329-1345. e24, 2020
Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
LM Richards, OKN Whitley, G MacLeod, FMG Cavalli, FJ Coutinho, ...
Nature Cancer 2 (2), 157-173, 2021
High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma
MJ Johnston, A Nikolic, N Ninkovic, P Guilhamon, FMG Cavalli, ...
Genome research 29 (8), 1211-1222, 2019
Characterization of bla SHV Genes on Plasmids from Escherichia coli and Salmonella enterica Isolates from Canadian Food Animals (2006-2007)
JG Pouget, FJ Coutinho, RJ Reid-Smith, P Boerlin
Applied and environmental microbiology 79 (12), 3864-3866, 2013
Intratumoral genetic and functional heterogeneity in pediatric glioblastoma
M Hoffman, AH Gillmor, DJ Kunz, MJ Johnston, A Nikolic, K Narta, ...
Cancer research 79 (9), 2111-2123, 2019
PRMT5 inhibition disrupts splicing and stemness in glioblastoma
P Sachamitr, JC Ho, FE Ciamponi, W Ba-Alawi, FJ Coutinho, ...
Nature communications 12 (1), 1-17, 2021
Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival
P Guilhamon, C Chesnelong, MM Kushida, A Nikolic, D Singhal, ...
Elife 10, e64090, 2021
Chromatin blueprint of glioblastoma stem cells reveals common drug candidates for distinct subtypes
P Guilhamon, MM Kushida, G MacLeod, SAM Tonekaboni, FMG Cavalli, ...
bioRxiv, 370726, 2018
Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival
P Guilhamon, MM Kushida, A Nikolic, D Singhal, G MacLeod, ...
bioRxiv, 370726, 2020
Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
K Isaev, L Jiang, S Wu, CA Lee, V Watters, V Fort, R Tsai, FJ Coutinho, ...
Cell Reports 37 (3), 109873, 2021
A comparison of data integration methods for single-cell RNA sequencing of cancer samples
LM Richards, M Riverin, S Mohanraj, S Ayyadhury, DC Croucher, ...
bioRxiv, 2021
Revelation of shared transcriptional gradients in glioblastoma tumors and cultured glioma stem cells
OK Whitley, LM Richards, F Cavalli, P Guilhamon, F Coutinho, M Kushida, ...
Cancer Research 80 (16 Supplement), 5724-5724, 2020
Single-cell transcriptomics uncovers clonal heterogeneity linked to drug response and cellular phenotype in adult brain tumor stem cells
LM Richards, O Whitley, FM Cavalli, Z Safikhani, F Coutinho, ...
Cancer Research 79 (13 Supplement), 967-967, 2019
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