André Mateus
TitleCited byYear
Rapid measurement of intracellular unbound drug concentrations
A Mateus, P Matsson, P Artursson
Molecular pharmaceutics 10 (6), 2467-2478, 2013
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
H Almqvist, H Axelsson, R Jafari, C Dan, A Mateus, M Haraldsson, ...
Nature communications 7, 11040, 2016
Species-specific activity of antibacterial drug combinations
AR Brochado, A Telzerow, J Bobonis, M Banzhaf, A Mateus, J Selkrig, ...
Nature 559 (7713), 259, 2018
Pervasive protein thermal stability variation during the cell cycle
I Becher, A Andrés-Pons, N Romanov, F Stein, M Schramm, F Baudin, ...
Cell 173 (6), 1495-1507. e18, 2018
Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes
A Mateus, TA Määttä, MM Savitski
Proteome science 15 (1), 13, 2016
Assessment of pharmacokinetic changes of meropenem during therapy in septic critically ill patients
J Goncalves-Pereira, NE Silva, A Mateus, C Pinho, P Povoa
BMC Pharmacology and Toxicology 15 (1), 21, 2014
Intracellular drug bioavailability: a new predictor of system dependent drug disposition
A Mateus, A Treyer, C Wegler, M Karlgren, P Matsson, P Artursson
Scientific reports 7, 43047, 2017
Direct measurement of intracellular compound concentration by rapidfire mass spectrometry offers insights into cell permeability
LJ Gordon, M Allen, P Artursson, MM Hann, BJ Leavens, A Mateus, ...
Journal of biomolecular screening 21 (2), 156-164, 2016
Prediction of intracellular exposure bridges the gap between target-and cell-based drug discovery
A Mateus, LJ Gordon, GJ Wayne, H Almqvist, H Axelsson, ...
Proceedings of the National Academy of Sciences 114 (30), E6231-E6239, 2017
Mechanistic modeling of pitavastatin disposition in sandwich-cultured human hepatocytes: a proteomics-informed bottom-up approach
A Vildhede, A Mateus, EK Khan, Y Lai, M Karlgren, P Artursson, ...
Drug Metabolism and Disposition 44 (4), 505-516, 2016
A high-throughput cell-based method to predict the unbound drug fraction in the brain
A Mateus, P Matsson, P Artursson
Journal of medicinal chemistry 57 (7), 3005-3010, 2014
Thermal proteome profiling in bacteria: probing protein state in vivo
A Mateus, J Bobonis, N Kurzawa, F Stein, D Helm, J Hevler, A Typas, ...
Molecular systems biology 14 (7), 2018
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors
S Llona-Minguez, A Hoglund, A Ghassemian, M Desroses, ...
Journal of medicinal chemistry 60 (10), 4279-4292, 2017
Identification of triazolothiadiazoles as potent inhibitors of the dCTP pyrophosphatase 1
S Llona-Minguez, A Hoglund, E Wiita, I Almlof, A Mateus, ...
Journal of medicinal chemistry 60 (5), 2148-2154, 2017
Intracellular drug bioavailability: Effect of neutral lipids and phospholipids
A Treyer, A Mateus, JR Wiśniewski, H Boriss, P Matsson, P Artursson
Molecular pharmaceutics 15 (6), 2224-2233, 2018
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
AM Filppula, R Parvizi, A Mateus, P Baranczewski, P Artursson
Scientific reports 9 (1), 5850, 2019
The outer membrane lipoprotein NlpI nucleates hydrolases within peptidoglycan multi-enzyme complexes in Escherichia coli
M Banzhaf, HCL Yau, J Verheul, A Lodge, G Kritikos, A Mateus, AK Hov, ...
bioRxiv, 609503, 2019
Intracellular unbound drug concentrations: methodology and application for understanding cellular drug exposure
A Mateus
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Articles 1–18