Manzamine A, a novel antitumor alkaloid from a sponge R Sakai, T Higa, CW Jefford, G Bernardinelli Journal of the American Chemical Society 108 (20), 6404-6405, 1986 | 617 | 1986 |
Identification of 12 hepatotoxins from a Homer Lake bloom of the cyanobacteria Microcystis aeruginosa, Microcystis viridis, and Microcystis wesenbergii: nine new microcystins M Namikoshi, KL Rinehart, R Sakai, RR Stotts, AM Dahlem, VR Beasley, ... The Journal of organic chemistry 57 (3), 866-872, 1992 | 359 | 1992 |
Manzamine B and C, two novel alkaloids from the sponge Haliclona sp. R Sakai, S Kohmoto, T Higa, CW Jefford, G Bernardinelli Tetrahedron Letters 28 (45), 5493-5496, 1987 | 249 | 1987 |
Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo. R Sakai, KL Rinehart, Y Guan, AH Wang Proceedings of the National Academy of Sciences 89 (23), 11456-11460, 1992 | 244 | 1992 |
Crambescidins: new antiviral and cytotoxic compounds from the sponge Crambe crambe EA Jares-Erijman, R Sakai, KL Rinehart The Journal of Organic Chemistry 56 (19), 5712-5715, 1991 | 212 | 1991 |
Dysiherbaine: a new neurotoxic amino acid from the Micronesian marine sponge Dysidea herbacea R Sakai, H Kamiya, M Murata, K Shimamoto Journal of the American Chemical Society 119 (18), 4112-4116, 1997 | 210 | 1997 |
Structure− activity relationships of the didemnins R Sakai, KL Rinehart, V Kishore, B Kundu, G Faircloth, JB Gloer, ... Journal of medicinal chemistry 39 (14), 2819-2834, 1996 | 210 | 1996 |
Structures of three new cyclic heptapeptide hepatotoxins produced by the cyanobacterium (blue-green alga) Nostoc sp. strain 152 M Namikoshi, KL Rinehart, R Sakai, K Sivonen, WW Carmichael The Journal of Organic Chemistry 55 (25), 6135-6139, 1990 | 203 | 1990 |
Bioactive compounds from aquatic and terrestrial sources KL Rinehart, TG Holt, NL Fregeau, PA Keifer, GR Wilson, TJ Perun Jr, ... Journal of natural products 53 (4), 771-792, 1990 | 198 | 1990 |
Characterization of novel L-threo-β-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters K Shimamoto, R Sakai, K Takaoka, N Yumoto, T Nakajima, SG Amara, ... Molecular pharmacology 65 (4), 1008-1015, 2004 | 195 | 2004 |
Didemnins and tunichlorin: novel natural products from the marine tunicate Trididemnum solidum KL Rinehart, V Kishore, KC Bible, R Sakai, DW Sullins, KM Li Journal of natural products 51 (1), 1-21, 1988 | 184 | 1988 |
Discorhabdin D, an antitumor alkaloid from the sponges Latrunculia brevis and Prianos sp NB Perry, JW Blunt, MHG Munro, T Higa, R Sakai The Journal of Organic Chemistry 53 (17), 4127-4128, 1988 | 176 | 1988 |
New manzamine alkaloids from a sponge of the genus Xestospongia T Ichiba, R Sakai, S Kohmoto, G Saucy, T Higa Tetrahedron letters 29 (25), 3083-3086, 1988 | 145 | 1988 |
Ecteinascidins: putative biosynthetic precursors and absolute stereochemistry R Sakai, EA Jares-Erijman, I Manzanares, MV Silva Elipe, KL Rinehart Journal of the American Chemical Society 118 (38), 9017-9023, 1996 | 142 | 1996 |
Molecular and crystal structures of ecteinascidins: potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata. Y Guan, R Sakai, KL Rinehart, AH Wang Journal of biomolecular structure & dynamics 10 (5), 793-818, 1993 | 141 | 1993 |
New nodularins: a general method for structure assignment M Namikoshi, BW Choi, R Sakai, F Sun, KL Rinehart, WW Carmichael, ... The Journal of organic chemistry 59 (9), 2349-2357, 1994 | 136 | 1994 |
Polycyclic guanidine-containing compounds from the Mediterranean sponge Crambe crambe: the structure of 13, 14, 15-isocrambescidin 800 and the absolute stereochemistry of the … EA Jares-Erijman, AL Ingrum, JR Carney, KL Rinehart, R Sakai The Journal of Organic Chemistry 58 (18), 4805-4808, 1993 | 118 | 1993 |
Antitumor macrodiolides isolated from a marine sponge Theonella sp.: Structure revision of misakinolide A Y Kato, N Fusetani, S Matsunaga, K Hashimoto, R Sakai, T Higa, ... Tetrahedron letters 28 (49), 6225-6228, 1987 | 116 | 1987 |
Octocoral chemical signaling selects and controls dinoflagellate symbionts K Koike, M Jimbo, R Sakai, M Kaeriyama, K Muramoto, T Ogata, ... The Biological Bulletin 207 (2), 80-86, 2004 | 111 | 2004 |
Differential activation of individual subunits in heteromeric kainate receptors GT Swanson, T Green, R Sakai, A Contractor, W Che, H Kamiya, ... Neuron 34 (4), 589-598, 2002 | 111 | 2002 |