| Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates … E McEwen, N Kedersha, B Song, D Scheuner, N Gilks, A Han, JJ Chen, ... Journal of Biological Chemistry 280 (17), 16925-16933, 2005 | 502 | 2005 |
| Heme‐regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency AP Han, C Yu, L Lu, Y Fujiwara, C Browne, G Chin, M Fleming, ... The EMBO journal, 2001 | 478 | 2001 |
| Regulation of protein synthesis by heme-regulated eIF-2α kinase JJ Chen, IM London Trends in biochemical sciences 20 (3), 105-108, 1995 | 430 | 1995 |
| Translation initiation control by heme-regulated eukaryotic initiation factor 2α kinase in erythroid cells under cytoplasmic stresses L Lu, AP Han, JJ Chen Molecular and cellular biology 21 (23), 7971-7980, 2001 | 420 | 2001 |
| Regulation of protein synthesis by the heme-regulated eIF2α kinase: relevance to anemias JJ Chen blood 109 (7), 2693-2699, 2007 | 383 | 2007 |
| Association of a M (r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature … J Chou, JJ Chen, M Gross, B Roizman Proceedings of the National Academy of Sciences 92 (23), 10516-10520, 1995 | 364 | 1995 |
| Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels (∗) IB Rosenwald, R Kaspar, D Rousseau, L Gehrke, P Leboulch, JJ Chen, ... Journal of Biological Chemistry 270 (36), 21176-21180, 1995 | 339 | 1995 |
| Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development HP Harding, Y Zhang, D Scheuner, JJ Chen, RJ Kaufman, D Ron Proceedings of the national academy of sciences 106 (6), 1832-1837, 2009 | 281 | 2009 |
| Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK R Kumar, S Azam, JM Sullivan, C Owen, DR Cavener, P Zhang, D Ron, ... Journal of neurochemistry 77 (5), 1418-1421, 2001 | 263 | 2001 |
| Graphene oxide induces toll-like receptor 4 (TLR4)-dependent necrosis in macrophages G Qu, S Liu, S Zhang, L Wang, X Wang, B Sun, N Yin, X Gao, T Xia, ... ACS nano 7 (7), 5732-5745, 2013 | 259 | 2013 |
| Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. TE Dever, JJ Chen, GN Barber, AM Cigan, L Feng, TF Donahue, ... Proceedings of the National Academy of Sciences 90 (10), 4616-4620, 1993 | 259 | 1993 |
| Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human … JJ Chen, MS Throop, L Gehrke, I Kuo, JK Pal, M Brodsky, IM London Proceedings of the National Academy of Sciences 88 (17), 7729-7733, 1991 | 256 | 1991 |
| Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis IB Rosenwald, JJ Chen, S Wang, L Savas, IM London, J Pullman Oncogene 18 (15), 2507-2517, 1999 | 243 | 1999 |
| Expression of the eukaryotic translation initiation factors 4E and 2α in non-Hodgkin's lymphomas S Wang, IB Rosenwald, MJ Hutzler, GA Pihan, L Savas, JJ Chen, ... The American journal of pathology 155 (1), 247-255, 1999 | 191 | 1999 |
| Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis RNVS Suragani, RS Zachariah, JG Velazquez, S Liu, CW Sun, ... Blood, The Journal of the American Society of Hematology 119 (22), 5276-5284, 2012 | 171 | 2012 |
| The cellular location of dihydroorotate dehydrogenase: relation to de novo biosynthesis of pyrimidines JJ Chen, ME Jones Archives of biochemistry and biophysics 176 (1), 82-90, 1976 | 169 | 1976 |
| Heme-regulated eIF2α kinase JJ Chen Translational control of gene expression, 2000 | 137 | 2000 |
| Two heme-binding domains of heme-regulated eukaryotic initiation factor-2α kinase: N terminus and kinase insertion M Rafie-Kolpin, PJ Chefalo, Z Hussain, J Hahn, S Uma, RL Matts, ... Journal of Biological Chemistry 275 (7), 5171-5178, 2000 | 132 | 2000 |
| Hemin enhances the differentiation of mouse 3T3 cells to adipocytes JJ Chen, IM London Cell 26 (1), 117-122, 1981 | 132 | 1981 |
| Heme-regulated eIF2α kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and β-thalassemia AP Han, MD Fleming, JJ Chen The Journal of clinical investigation 115 (6), 1562-1570, 2005 | 129 | 2005 |
