Joseph W. Lewcock
Joseph W. Lewcock
CSO and Head of Discovery, Denali Therapeutics
Verified email at
Cited by
Cited by
A feedback mechanism regulates monoallelic odorant receptor expression
JW Lewcock, RR Reed
Proceedings of the National Academy of Sciences 101 (4), 1069-1074, 2004
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
TA Watkins, B Wang, S Huntwork-Rodriguez, J Yang, Z Jiang, ...
Proceedings of the National Academy of Sciences 110 (10), 4039-4044, 2013
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics
JW Lewcock, N Genoud, K Lettieri, SL Pfaff
Neuron 56 (4), 604-620, 2007
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
A Sengupta Ghosh, B Wang, CD Pozniak, M Chen, RJ Watts, JW Lewcock
The Journal of cell biology 194 (5), 751-764, 2011
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits
CP Myers, JW Lewcock, MG Hanson, S Gosgnach, JB Aimone, FH Gage, ...
Neuron 46 (1), 37-49, 2005
Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection
SS Wang, JW Lewcock, P Feinstein, P Mombaerts, RR Reed
Development 131 (6), 1377-1388, 2004
FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code
R Shirasaki, JW Lewcock, K Lettieri, SL Pfaff
Neuron 50 (6), 841-853, 2006
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
S Huntwork-Rodriguez, B Wang, T Watkins, AS Ghosh, CD Pozniak, ...
Journal of Cell Biology 202 (5), 747-763, 2013
Presenilin-dependent receptor processing is required for axon guidance
G Bai, O Chivatakarn, D Bonanomi, K Lettieri, L Franco, C Xia, E Stein, ...
Cell 144 (1), 106-118, 2011
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
CE Le Pichon, WJ Meilandt, S Dominguez, H Solanoy, H Lin, H Ngu, ...
Science translational medicine 9 (403), 2017
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
CD Pozniak, A Sengupta Ghosh, A Gogineni, JE Hanson, SH Lee, ...
Journal of Experimental Medicine 210 (12), 2553-2567, 2013
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
CS Lobsiger, S Boillée, C Pozniak, AM Khan, M McAlonis-Downes, ...
Proceedings of the National Academy of Sciences 110 (46), E4385-E4392, 2013
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models
S Patel, F Cohen, BJ Dean, K De La Torre, G Deshmukh, AA Estrada, ...
Journal of medicinal chemistry 58 (1), 401-418, 2015
The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)
AL Boxer, M Gold, E Huey, WT Hu, H Rosen, J Kramer, FB Gao, ...
Alzheimer's & Dementia 9 (2), 189-198, 2013
Spatially coordinated kinase signaling regulates local axon degeneration
M Chen, JA Maloney, DY Kallop, JK Atwal, SJ Tam, K Baer, H Kissel, ...
Journal of Neuroscience 32 (39), 13439-13453, 2012
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization
K Stanger, M Steffek, L Zhou, CD Pozniak, C Quan, Y Franke, J Tom, ...
Nature chemical biology 8 (7), 655-660, 2012
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6
CE Heise, J Murray, KE Augustyn, B Bravo, P Chugha, F Cohen, ...
PLoS One 7 (12), e50864, 2012
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
M Larhammar, S Huntwork-Rodriguez, Z Jiang, H Solanoy, AS Ghosh, ...
Elife 6, e20725, 2017
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge
AA Nugent, K Lin, B Van Lengerich, S Lianoglou, L Przybyla, SS Davis, ...
Neuron 105 (5), 837-854. e9, 2020
Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS/FTD
MY Fang, S Markmiller, AQ Vu, A Javaherian, WE Dowdle, P Jolivet, ...
Neuron 103 (5), 802-819. e11, 2019
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