Liam R. Brunham
Liam R. Brunham
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Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I
JM Timmins, JY Lee, E Boudyguina, KD Kluckman, LR Brunham, A Mulya, ...
The Journal of clinical investigation 115 (5), 1333-1342, 2005
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
LR Brunham, JK Kruit, J Iqbal, C Fievet, JM Timmins, TD Pape, ...
The Journal of clinical investigation 116 (4), 1052-1062, 2006
β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
LR Brunham, JK Kruit, TD Pape, JM Timmins, AQ Reuwer, Z Vasanji, ...
Nature medicine 13 (3), 340-347, 2007
Efflux and Atherosclerosis: The Clinical and Biochemical Impact of Variations in the ABCA1 Gene
RR Singaraja, LR Brunham, H Visscher, JJP Kastelein, MR Hayden
Arteriosclerosis, thrombosis, and vascular biology 23 (8), 1322-1332, 2003
Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin
LR Brunham, PJ Lansberg, L Zhang, F Miao, C Carter, GK Hovingh, ...
The pharmacogenomics journal 12 (3), 233-237, 2012
Variations on a Gene: Rare and Common Variants in ABCA1 and Their Impact on HDL Cholesterol Levels and Atherosclerosis
LR Brunham, RR Singaraja, MR Hayden
Annu. Rev. Nutr. 26, 105-129, 2006
Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene
LR Brunham, RR Singaraja, TD Pape, A Kejariwal, PD Thomas, ...
PLoS Genet 1 (6), e83, 2005
Cholesterol in islet dysfunction and type 2 diabetes
LR Brunham, JK Kruit, CB Verchere, MR Hayden
The Journal of clinical investigation 118 (2), 403-408, 2008
HDL and LDL cholesterol significantly influence β-cell function in type 2 diabetes mellitus
JK Kruit, LR Brunham, CB Verchere, MR Hayden
Current opinion in lipidology 21 (3), 178-185, 2010
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function
JM Karasinska, F Rinninger, D Lütjohann, P Ruddle, S Franciosi, JK Kruit, ...
Journal of Neuroscience 29 (11), 3579-3589, 2009
Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1
CL Wellington, LR Brunham, S Zhou, RR Singaraja, H Visscher, A Gelfer, ...
Journal of lipid research 44 (8), 1470-1480, 2003
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
F Aminkeng, AP Bhavsar, H Visscher, SR Rassekh, Y Li, JW Lee, ...
Nature genetics 47 (9), 1079-1084, 2015
Optimizing cholesterol treatment in patients with muscle complaints
RS Rosenson, S Baker, M Banach, KM Borow, LT Braun, E Bruckert, ...
Journal of the American College of Cardiology 70 (10), 1290-1301, 2017
Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels
LR Brunham, JK Kruit, TD Pape, JS Parks, F Kuipers, MR Hayden
Circulation research 99 (7), 672-674, 2006
Carriers of loss-of-function mutations in ABCA1 display pancreatic β-cell dysfunction
M Vergeer, LR Brunham, J Koetsveld, JK Kruit, CB Verchere, ...
Diabetes Care 33 (4), 869-874, 2010
Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function …
JK Kruit, PHC Kremer, L Dai, R Tang, P Ruddle, W de Haan, LR Brunham, ...
Diabetologia 53 (6), 1110-1119, 2010
Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro
RR Singaraja, H Visscher, ER James, A Chroni, JM Coutinho, ...
Circulation research 99 (4), 389-397, 2006
Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis
LR Brunham, RR Singaraja, MN Duong, JM Timmins, C Fievet, N Bissada, ...
Arteriosclerosis, thrombosis, and vascular biology 29 (4), 548-554, 2009
Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function
JK Kruit, N Wijesekara, C Westwell-Roper, T Vanmierlo, W De Haan, ...
Diabetes 61 (3), 659-664, 2012
RR Singaraja, M Van Eck, N Bissada, F Zimetti, HL Collins, ...
Circulation 114 (12), 1301-1309, 2006
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