| Antibiotic resistance—the need for global solutions R Laxminarayan, A Duse, C Wattal, AKM Zaidi, HFL Wertheim, ... The Lancet infectious diseases 13 (12), 1057-1098, 2013 | 5253 | 2013 |
| Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori RA Alm, LSL Ling, DT Moir, BL King, ED Brown, PC Doig, DR Smith, ... Nature 397 (6715), 176-180, 1999 | 2459 | 1999 |
| Antibacterial drug discovery in the resistance era ED Brown, GD Wright Nature 529 (7586), 336-343, 2016 | 2323 | 2016 |
| A deep learning approach to antibiotic discovery JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, ... Cell 180 (4), 688-702. e13, 2020 | 2042 | 2020 |
| A comprehensive, CRISPR-based functional analysis of essential genes in bacteria JM Peters, A Colavin, H Shi, TL Czarny, MH Larson, S Wong, JS Hawkins, ... Cell 165 (6), 1493-1506, 2016 | 723 | 2016 |
| CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database BP Alcock, W Huynh, R Chalil, KW Smith, AR Raphenya, MA Wlodarski, ... Nucleic acids research 51 (D1), D690-D699, 2023 | 665 | 2023 |
| Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy L Ejim, MA Farha, SB Falconer, J Wildenhain, BK Coombes, M Tyers, ... Nature chemical biology 7 (6), 348-350, 2011 | 585 | 2011 |
| Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells E Sachlos, RM Risueño, S Laronde, Z Shapovalova, JH Lee, J Russell, ... Cell 149 (6), 1284-1297, 2012 | 573 | 2012 |
| Drug repurposing for antimicrobial discovery MA Farha, ED Brown Nature microbiology 4 (4), 565-577, 2019 | 356 | 2019 |
| Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance JM Stokes, CR MacNair, B Ilyas, S French, JP Côté, C Bouwman, ... Nature microbiology 2 (5), 1-8, 2017 | 329 | 2017 |
| MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli ED Brown, EI Vivas, CT Walsh, R Kolter Journal of bacteriology 177 (14), 4194-4197, 1995 | 317 | 1995 |
| Strategies for target identification of antimicrobial natural products MA Farha, ED Brown Natural product reports 33 (5), 668-680, 2016 | 304 | 2016 |
| Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics CR MacNair, JM Stokes, LA Carfrae, AA Fiebig-Comyn, BK Coombes, ... Nature communications 9 (1), 458, 2018 | 292 | 2018 |
| Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus MA Farha, CP Verschoor, D Bowdish, ED Brown Chemistry & biology 20 (9), 1168-1178, 2013 | 258 | 2013 |
| High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase JE Blanchard, NH Elowe, C Huitema, PD Fortin, JD Cechetto, LD Eltis, ... Chemistry & biology 11 (10), 1445-1453, 2004 | 258 | 2004 |
| Helicobacter pylori Physiology Predicted from Genomic Comparison of Two Strains P Doig, BL de Jonge, RA Alm, ED Brown, M Uria-Nickelsen, B Noonan, ... Microbiology and Molecular Biology Reviews 63 (3), 675-707, 1999 | 243 | 1999 |
| Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams MA Farha, A Leung, EW Sewell, MA D’Elia, SE Allison, L Ejim, PM Pereira, ... ACS chemical biology 8 (1), 226-233, 2013 | 231 | 2013 |
| New targets and screening approaches in antimicrobial drug discovery ED Brown, GD Wright Chemical reviews 105 (2), 759-774, 2005 | 224 | 2005 |
| Wall Teichoic Acid Polymers Are Dispensable for Cell Viability in Bacillus subtilis MA D'Elia, KE Millar, TJ Beveridge, ED Brown Journal of bacteriology 188 (23), 8313-8316, 2006 | 223 | 2006 |
| Lesions in Teichoic Acid Biosynthesis in Staphylococcus aureus Lead to a Lethal Gain of Function in the Otherwise Dispensable Pathway MA D'Elia, MP Pereira, YS Chung, W Zhao, A Chau, TJ Kenney, ... Journal of bacteriology 188 (12), 4183-4189, 2006 | 222 | 2006 |
Shawn FrenchMcMaster UniversityVerified email at mcmaster.ca
