Eric D Brown
Eric D Brown
Professor of Biochemistry, McMaster University
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TitleCited byYear
Antibiotic resistance—the need for global solutions
R Laxminarayan, A Duse, C Wattal, AKM Zaidi, HFL Wertheim, ...
The Lancet infectious diseases 13 (12), 1057-1098, 2013
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
RA Alm, LSL Ling, DT Moir, BL King, ED Brown, PC Doig, DR Smith, ...
Nature 397 (6715), 176-180, 1999
Antibacterial drug discovery in the resistance era
ED Brown, GD Wright
Nature 529 (7586), 336-343, 2016
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells
E Sachlos, RM Risueño, S Laronde, Z Shapovalova, JH Lee, J Russell, ...
Cell 149 (6), 1284-1297, 2012
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
L Ejim, MA Farha, SB Falconer, J Wildenhain, BK Coombes, M Tyers, ...
Nature chemical biology 7 (6), 348, 2011
A comprehensive, CRISPR-based functional analysis of essential genes in bacteria
JM Peters, A Colavin, H Shi, TL Czarny, MH Larson, S Wong, JS Hawkins, ...
Cell 165 (6), 1493-1506, 2016
MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli.
ED Brown, EI Vivas, CT Walsh, R Kolter
Journal of bacteriology 177 (14), 4194-4197, 1995
Helicobacter pylori physiology predicted from genomic comparison of two strains
P Doig, BL de Jonge, RA Alm, ED Brown, M Uria-Nickelsen, B Noonan, ...
Microbiol. Mol. Biol. Rev. 63 (3), 675-707, 1999
New targets and screening approaches in antimicrobial drug discovery
ED Brown, GD Wright
Chemical reviews 105 (2), 759-774, 2005
Lesions in teichoic acid biosynthesis in Staphylococcus aureus lead to a lethal gain of function in the otherwise dispensable pathway
MA D'Elia, MP Pereira, YS Chung, W Zhao, A Chau, TJ Kenney, ...
Journal of Bacteriology 188 (12), 4183-4189, 2006
Wall teichoic acid polymers are dispensable for cell viability in Bacillus subtilis
MA D'Elia, KE Millar, TJ Beveridge, ED Brown
Journal of bacteriology 188 (23), 8313-8316, 2006
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycin
JL Marquardt, ED Brown, WS Lane, TM Haley, Y Ichikawa, CH Wong, ...
Biochemistry 33 (35), 10646-10651, 1994
Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole
M Spitzer, E Griffiths, KM Blakely, J Wildenhain, L Ejim, L Rossi, ...
Molecular systems biology 7 (1), 2011
Development and Characterization of a Xylose-Dependent System for Expression of Cloned Genes inBacillus subtilis: Conditional Complementation of a Teichoic Acid Mutant
AP Bhavsar, X Zhao, ED Brown
Appl. Environ. Microbiol. 67 (1), 403-410, 2001
Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams
MA Farha, A Leung, EW Sewell, MA D’Elia, SE Allison, L Ejim, PM Pereira, ...
ACS chemical biology 8 (1), 226-233, 2013
An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase
S Orlicky, X Tang, V Neduva, N Elowe, ED Brown, F Sicheri, M Tyers
Nature biotechnology 28 (7), 733, 2010
High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase
JE Blanchard, NH Elowe, C Huitema, PD Fortin, JD Cechetto, LD Eltis, ...
Chemistry & biology 11 (10), 1445-1453, 2004
Teichoic acid is an essential polymer in Bacillus subtilis that is functionally distinct from teichuronic acid
AP Bhavsar, LK Erdman, JW Schertzer, ED Brown
Journal of bacteriology 186 (23), 7865-7873, 2004
Strategies for target identification of antimicrobial natural products
MA Farha, ED Brown
Natural product reports 33 (5), 668-680, 2016
Studies of the interaction of Escherichia coli YjeQ with the ribosome in vitro
DM Daigle, ED Brown
Journal of bacteriology 186 (5), 1381-1387, 2004
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