Perrin Baker
Perrin Baker
Maple Leaf Foods
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Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
P Baker, PJ Hill, BD Snarr, N Alnabelseya, MJ Pestrak, MJ Lee, ...
Science advances 2 (5), e1501632, 2016
PelA deacetylase activity is required for Pel polysaccharide synthesis in Pseudomonas aeruginosa
KM Colvin, N Alnabelseya, P Baker, JC Whitney, PL Howell, MR Parsek
Journal of bacteriology 195 (10), 2329-2339, 2013
Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus*♦
NC Bamford, BD Snarr, FN Gravelat, DJ Little, MJ Lee, CA Zacharias, ...
Journal of Biological Chemistry 290 (46), 27438-27450, 2015
Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity
BD Snarr, P Baker, NC Bamford, Y Sato, H Liu, M Lehoux, FN Gravelat, ...
Proceedings of the National Academy of Sciences 114 (27), 7124-7129, 2017
Characterization of the Pseudomonas aeruginosa glycoside hydrolase PslG reveals that its levels are critical for Psl polysaccharide biosynthesis and biofilm formation
P Baker, GB Whitfield, PJ Hill, DJ Little, MJ Pestrak, H Robinson, ...
Journal of Biological Chemistry 290 (47), 28374-28387, 2015
Treatment with the Pseudomonas aeruginosa glycoside hydrolase PslG combats wound infection by improving antibiotic efficacy and host innate immune activity
MJ Pestrak, P Baker, S Dellos-Nolan, PJ Hill, D Passos da Silva, H Silver, ...
Antimicrobial agents and chemotherapy 63 (6), 10.1128/aac. 00234-19, 2019
Structural and functional characterization of Pseudomonas aeruginosa AlgX: role of AlgX in alginate acetylation
LM Riley, JT Weadge, P Baker, H Robinson, JDC Codée, PA Tipton, ...
Journal of Biological Chemistry 288 (31), 22299-22314, 2013
P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation
P Baker, T Ricer, PJ Moynihan, EN Kitova, MTC Walvoort, DJ Little, ...
PLoS pathogens 10 (8), e1004334, 2014
PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β (1, 6)-N-acetylglucosamine and can disrupt bacterial biofilms
DJ Little, R Pfoh, F Le Mauff, NC Bamford, C Notte, P Baker, M Guragain, ...
PLoS pathogens 14 (4), e1006998, 2018
Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases
F Le Mauff, NC Bamford, N Alnabelseya, Y Zhang, P Baker, H Robinson, ...
Journal of Biological Chemistry 294 (28), 10760-10772, 2019
Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling
W Wang, P Baker, SYK Seah
Biochemistry 49 (17), 3774-3782, 2010
Non-eluting, surface-bound enzymes disrupt surface attachment of bacteria by continuous biofilm polysaccharide degradation
D Asker, TS Awad, P Baker, PL Howell, BD Hatton
Biomaterials 167, 168-176, 2018
Characterization of an aldolase− dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway
P Baker, D Pan, J Carere, A Rossi, W Wang, SYK Seah
Biochemistry 48 (27), 6551-6558, 2009
Rational design of stereoselectivity in the class II pyruvate aldolase BphI
P Baker, SYK Seah
Journal of the American Chemical Society 134 (1), 507-513, 2012
An epigenetic mechanism regulates germ cell-specific expression of the porcine Deleted in Azoospermia-Like (DAZL) gene
K Linher, Q Cheung, P Baker, G Bedecarrats, K Shiota, J Li
Differentiation 77 (4), 335-349, 2009
Probing the molecular basis of substrate specificity, stereospecificity, and catalysis in the class II pyruvate aldolase, BphI
P Baker, J Carere, SYK Seah
Biochemistry 50 (17), 3559-3569, 2011
Protein–protein interactions and substrate channeling in Orthologous and chimeric aldolase–dehydrogenase complexes
P Baker, C Hillis, J Carere, SYK Seah
Biochemistry 51 (9), 1942-1952, 2012
Investigating the molecular determinants for substrate channeling in BphI–BphJ, an aldolase–dehydrogenase complex from the polychlorinated biphenyls degradation pathway
J Carere, P Baker, SYK Seah
Biochemistry 50 (39), 8407-8416, 2011
Substrate specificity, substrate channeling, and allostery in BphJ: an acylating aldehyde dehydrogenase associated with the pyruvate aldolase BphI
P Baker, J Carere, SYK Seah
Biochemistry 51 (22), 4558-4567, 2012
Preclinical evaluation of recombinant microbial glycoside hydrolases in the prevention of experimental invasive aspergillosis
H Ostapska, D Raju, M Lehoux, I Lacdao, S Gilbert, P Sivarajah, ...
Mbio 12 (5), 10.1128/mbio. 02446-21, 2021
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