Perrin Baker
Perrin Baker
Covalon Technologies
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Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
P Baker, PJ Hill, BD Snarr, N Alnabelseya, MJ Pestrak, MJ Lee, ...
Science advances 2 (5), e1501632, 2016
892016
PelA deacetylase activity is required for Pel polysaccharide synthesis in Pseudomonas aeruginosa
KM Colvin, N Alnabelseya, P Baker, JC Whitney, PL Howell, MR Parsek
Journal of bacteriology 195 (10), 2329-2339, 2013
562013
Structural and functional characterization of Pseudomonas aeruginosa AlgX role of AlgX in alginate acetylation
LM Riley, JT Weadge, P Baker, H Robinson, JDC Codée, PA Tipton, ...
Journal of Biological Chemistry 288 (31), 22299-22314, 2013
482013
Sph3 is a glycoside hydrolase required for the biosynthesis of galactosaminogalactan in Aspergillus fumigatus
NC Bamford, BD Snarr, FN Gravelat, DJ Little, MJ Lee, CA Zacharias, ...
Journal of Biological Chemistry 290 (46), 27438-27450, 2015
442015
Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling
W Wang, P Baker, SYK Seah
Biochemistry 49 (17), 3774-3782, 2010
402010
Characterization of an aldolase− dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway
P Baker, D Pan, J Carere, A Rossi, W Wang, SYK Seah
Biochemistry 48 (27), 6551-6558, 2009
392009
An epigenetic mechanism regulates germ cell-specific expression of the porcine Deleted in Azoospermia-Like (DAZL) gene
K Linher, Q Cheung, P Baker, G Bedecarrats, K Shiota, J Li
Differentiation 77 (4), 335-349, 2009
392009
P. aeruginosa SGNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation
P Baker, T Ricer, PJ Moynihan, EN Kitova, MTC Walvoort, DJ Little, ...
PLoS pathogens 10 (8), 2014
372014
Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity
BD Snarr, P Baker, NC Bamford, Y Sato, H Liu, M Lehoux, FN Gravelat, ...
Proceedings of the National Academy of Sciences 114 (27), 7124-7129, 2017
362017
Rational design of stereoselectivity in the class II pyruvate aldolase BphI
P Baker, SYK Seah
Journal of the American Chemical Society 134 (1), 507-513, 2012
332012
Characterization of the Pseudomonas aeruginosa glycoside hydrolase PslG reveals that its levels are critical for Psl polysaccharide biosynthesis and biofilm formation
P Baker, GB Whitfield, PJ Hill, DJ Little, MJ Pestrak, H Robinson, ...
Journal of Biological Chemistry 290 (47), 28374-28387, 2015
312015
Probing the molecular basis of substrate specificity, stereospecificity, and catalysis in the class II pyruvate aldolase, BphI
P Baker, J Carere, SYK Seah
Biochemistry 50 (17), 3559-3569, 2011
272011
Investigating the molecular determinants for substrate channeling in BphI–BphJ, an aldolase–dehydrogenase complex from the polychlorinated biphenyls degradation pathway
J Carere, P Baker, SYK Seah
Biochemistry 50 (39), 8407-8416, 2011
222011
Protein–protein interactions and substrate channeling in orthologous and chimeric aldolase–dehydrogenase complexes
P Baker, C Hillis, J Carere, SYK Seah
Biochemistry 51 (9), 1942-1952, 2012
182012
PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β (1, 6)-N-acetylglucosamine and can disrupt bacterial biofilms
DJ Little, R Pfoh, F Le Mauff, NC Bamford, C Notte, P Baker, M Guragain, ...
PLoS pathogens 14 (4), e1006998, 2018
162018
Substrate specificity, substrate channeling, and allostery in BphJ: an acylating aldehyde dehydrogenase associated with the pyruvate aldolase BphI
P Baker, J Carere, SYK Seah
Biochemistry 51 (22), 4558-4567, 2012
142012
Non-eluting, surface-bound enzymes disrupt surface attachment of bacteria by continuous biofilm polysaccharide degradation
D Asker, TS Awad, P Baker, PL Howell, BD Hatton
Biomaterials 167, 168-176, 2018
112018
Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases
F Le Mauff, NC Bamford, N Alnabelseya, Y Zhang, P Baker, H Robinson, ...
Journal of Biological Chemistry 294 (28), 10760-10772, 2019
72019
Treatment with the Pseudomonas aeruginosa glycoside hydrolase PslG combats wound infection by improving antibiotic efficacy and host innate immune activity
MJ Pestrak, P Baker, S Dellos-Nolan, PJ Hill, DP da Silva, H Silver, ...
Antimicrobial agents and chemotherapy 63 (6), e00234-19, 2019
52019
Molecular mechanisms of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases
MF Le, NC Bamford, N Alnabelseya, Y Zhang, P Baker, H Robinson, ...
Journal of Biological Chemistry 294, 13, 2019
2019
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Articles 1–20