Perrin Baker
Perrin Baker
Maple Leaf Foods
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Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
P Baker, PJ Hill, BD Snarr, N Alnabelseya, MJ Pestrak, MJ Lee, ...
Science advances 2 (5), e1501632, 2016
1142016
PelA deacetylase activity is required for Pel polysaccharide synthesis in Pseudomonas aeruginosa
KM Colvin, N Alnabelseya, P Baker, JC Whitney, PL Howell, MR Parsek
Journal of bacteriology 195 (10), 2329-2339, 2013
672013
Structural and functional characterization of Pseudomonas aeruginosa AlgX role of AlgX in alginate acetylation
LM Riley, JT Weadge, P Baker, H Robinson, JDC Codée, PA Tipton, ...
Journal of Biological Chemistry 288 (31), 22299-22314, 2013
502013
Sph3 is a glycoside hydrolase required for the biosynthesis of galactosaminogalactan in Aspergillus fumigatus
NC Bamford, BD Snarr, FN Gravelat, DJ Little, MJ Lee, CA Zacharias, ...
Journal of Biological Chemistry 290 (46), 27438-27450, 2015
482015
P. aeruginosa SGNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation
P Baker, T Ricer, PJ Moynihan, EN Kitova, MTC Walvoort, DJ Little, ...
PLoS Pathog 10 (8), e1004334, 2014
432014
Characterization of an aldolase− dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway
P Baker, D Pan, J Carere, A Rossi, W Wang, SYK Seah
Biochemistry 48 (27), 6551-6558, 2009
422009
Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity
BD Snarr, P Baker, NC Bamford, Y Sato, H Liu, M Lehoux, FN Gravelat, ...
Proceedings of the National Academy of Sciences 114 (27), 7124-7129, 2017
412017
An epigenetic mechanism regulates germ cell-specific expression of the porcine Deleted in Azoospermia-Like (DAZL) gene
K Linher, Q Cheung, P Baker, G Bedecarrats, K Shiota, J Li
Differentiation 77 (4), 335-349, 2009
412009
Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling
W Wang, P Baker, SYK Seah
Biochemistry 49 (17), 3774-3782, 2010
392010
Characterization of the Pseudomonas aeruginosa glycoside hydrolase PslG reveals that its levels are critical for Psl polysaccharide biosynthesis and biofilm formation
P Baker, GB Whitfield, PJ Hill, DJ Little, MJ Pestrak, H Robinson, ...
Journal of Biological Chemistry 290 (47), 28374-28387, 2015
352015
Rational design of stereoselectivity in the class II pyruvate aldolase BphI
P Baker, SYK Seah
Journal of the American Chemical Society 134 (1), 507-513, 2012
342012
PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β (1, 6)-N-acetylglucosamine and can disrupt bacterial biofilms
DJ Little, R Pfoh, F Le Mauff, NC Bamford, C Notte, P Baker, M Guragain, ...
PLoS pathogens 14 (4), e1006998, 2018
272018
Probing the molecular basis of substrate specificity, stereospecificity, and catalysis in the class II pyruvate aldolase, BphI
P Baker, J Carere, SYK Seah
Biochemistry 50 (17), 3559-3569, 2011
272011
Investigating the molecular determinants for substrate channeling in BphI–BphJ, an aldolase–dehydrogenase complex from the polychlorinated biphenyls degradation pathway
J Carere, P Baker, SYK Seah
Biochemistry 50 (39), 8407-8416, 2011
222011
Protein–protein interactions and substrate channeling in orthologous and chimeric aldolase–dehydrogenase complexes
P Baker, C Hillis, J Carere, SYK Seah
Biochemistry 51 (9), 1942-1952, 2012
202012
Non-eluting, surface-bound enzymes disrupt surface attachment of bacteria by continuous biofilm polysaccharide degradation
D Asker, TS Awad, P Baker, PL Howell, BD Hatton
Biomaterials 167, 168-176, 2018
182018
Treatment with the Pseudomonas aeruginosa glycoside hydrolase PslG combats wound infection by improving antibiotic efficacy and host innate immune activity
MJ Pestrak, P Baker, S Dellos-Nolan, PJ Hill, DP da Silva, H Silver, ...
Antimicrobial agents and chemotherapy 63 (6), 2019
162019
Substrate specificity, substrate channeling, and allostery in BphJ: an acylating aldehyde dehydrogenase associated with the pyruvate aldolase BphI
P Baker, J Carere, SYK Seah
Biochemistry 51 (22), 4558-4567, 2012
152012
Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases
F Le Mauff, NC Bamford, N Alnabelseya, Y Zhang, P Baker, H Robinson, ...
Journal of Biological Chemistry 294 (28), 10760-10772, 2019
132019
Molecular basis for PNAG-dependent biofilm disruption by PgaB
R Pfoh, DJ Little, F Le Mauff, NC Bamford, C Notte, P Baker, M Guragain, ...
Foundations of Crystallography 74, a101, 2018
2018
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Articles 1–20