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Andrew Michael Beekman
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Fungal metabolites as pharmaceuticals
AM Beekman, RA Barrow
Australian Journal of Chemistry 67 (6), 827-843, 2014
662014
Small‐molecule and peptide inhibitors of the pro‐survival protein Mcl‐1
AM Beekman, LA Howell
ChemMedChem 11 (8), 802-813, 2016
492016
Syntheses of the fungal metabolites boletopsins 7, 11, and 12 from the Papua New Guinea medicinal mushroom Boletopsis sp.
AM Beekman, RA Barrow
The Journal of organic chemistry 79 (3), 1017-1024, 2014
242014
Syntheses of the fungal metabolites boletopsins 7, 11, and 12 from the Papua New Guinea medicinal mushroom Boletopsis sp.
AM Beekman, RA Barrow
The Journal of organic chemistry 79 (3), 1017-1024, 2014
242014
Identification of Boletopsin 11 and 12, Antibiotics from the Traditionally Used Fungus Boletopsis sp.
SW Wossa, AM Beekman, P Ma, O Kevo, RA Barrow
Asian Journal of Organic Chemistry 2 (7), 565-567, 2013
222013
First syntheses of the biologically active fungal metabolites pestalotiopsones A, B, C and F
AM Beekman, EC Martinez, RA Barrow
Organic & Biomolecular Chemistry 11 (7), 1109-1115, 2013
222013
Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4
SC Mills, L Howell, A Beekman, L Stokes, A Mueller
Cellular signalling 42, 88-96, 2018
212018
Identification of Small‐Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia‐1 (Mcl‐1)
AM Beekman, MA O'Connell, LA Howell
ChemMedChem 11 (8), 840-844, 2016
172016
Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
AM Beekman, MMD Cominetti, SJ Walpole, S Prabhu, MA O'Connell, ...
Chemical Science 10 (16), 4502-4508, 2019
152019
Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis
JD Myrtle, AM Beekman, RA Barrow
Organic & Biomolecular Chemistry 14 (35), 8253-8260, 2016
132016
Discovery and synthesis of Boletopsins 13 and 14, brominated fungal metabolites of terrestrial origin
AM Beekman, SW Wossa, O Kevo, P Ma, RA Barrow
Journal of natural products 78 (8), 2133-2135, 2015
122015
Peptide‐Directed Binding for the Discovery of Modulators of α‐Helix‐Mediated Protein–Protein Interactions: Proof‐of‐Concept Studies with the Apoptosis Regulator Mcl‐1
AM Beekman, MA O'Connell, LA Howell
Angewandte Chemie 129 (35), 10582-10586, 2017
112017
Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers
ZR Goddard, AM Beekman, MMD Cominetti, MA O'Connell, I Chambrier, ...
RSC Medicinal Chemistry 12 (2), 288-292, 2021
102021
Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through enantiopure synthesis
AM Beekman, RA Barrow
Journal of natural products 76 (11), 2054-2059, 2013
102013
Syntheses of cytosporones A, C, J, K, and N, metabolites from medicinal fungi
AM Beekman, RA Barrow
Australian Journal of Chemistry 68 (10), 1583-1592, 2015
82015
Insights into the structure-activity relationship of glycosides as positive allosteric modulators acting on P2X7 receptors
W Piyasirananda, A Beekman, A Ganesan, S Bidula, L Stokes
Molecular pharmacology 99 (2), 163-174, 2021
62021
A Peptide–Duocarmycin Conjugate Targeting the Thomsen-Friedenreich Antigen Has Potent and Selective Antitumor Activity
OC Cartwright, AM Beekman, MMD Cominetti, DA Russell, M Searcey
Bioconjugate Chemistry 31 (7), 1745-1749, 2020
62020
A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase
AM Beekman, MMD Cominetti, OC Cartwright, DL Boger, M Searcey
MedChemComm 10 (12), 2170-2174, 2019
42019
Duocarmycins as Antibody–Drug Conjugate (ADC) Payloads
AM Beekman, MMD Cominetti, M Searcey
Cytotoxic Payloads for Antibody–Drug Conjugates 71, 187, 2019
32019
In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery
LA Howell, AM Beekman
RSC Chemical Biology 2 (1), 215-219, 2021
12021
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