Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer X Liu, K Olszewski, Y Zhang, EW Lim, J Shi, X Zhang, J Zhang, H Lee, ... Nature cell biology 22 (4), 476-486, 2020 | 286 | 2020 |
Serine restriction alters sphingolipid diversity to constrain tumour growth T Muthusamy, T Cordes, MK Handzlik, L You, EW Lim, J Gengatharan, ... Nature 586 (7831), 790-795, 2020 | 177 | 2020 |
3D collagen architecture regulates cell adhesion through degradability, thereby controlling metabolic and oxidative stress DO Velez, SK Ranamukhaarachchi, A Kumar, RN Modi, EW Lim, ... Integrative Biology 11 (5), 221-234, 2019 | 45 | 2019 |
g-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A X Gao, L Zhao, S Liu, Y Li, S Xia, D Chen, MW Wu, Shaoxiong, Q Dai, ... Molecular Cell 76, 1-15, 2019 | 42* | 2019 |
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function BJ Gheller, JE Blum, EW Lim, MK Handzlik, EHH Fong, AC Ko, S Khanna, ... Molecular metabolism 43, 101106, 2021 | 40 | 2021 |
Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease K Eade, ML Gantner, JA Hostyk, T Nagasaki, S Giles, R Fallon, ... Nature metabolism 3 (3), 366-377, 2021 | 31 | 2021 |
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy I Perea-Gil, T Seeger, AAN Bruyneel, V Termglinchan, E Monte, EW Lim, ... European Heart Journal 43 (36), 3477-3489, 2022 | 28 | 2022 |
A small molecule fluorogenic probe for the detection of sphingosine in living cells AK Rudd, N Mittal, EW Lim, CM Metallo, NK Devaraj Journal of the American Chemical Society 142 (42), 17887-17891, 2020 | 19 | 2020 |
An integrated robotic system for high‐throughput process development of cell and virus culture conditions: Application to biosafety level 2 live virus vaccines C Daniels, J Rodriguez, E Lim, M Wenger Engineering in Life Sciences 16 (2), 202-209, 2016 | 11 | 2016 |
Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in PolgD257A mice EW Lim, MK Handzlik, E Trefts, JM Gengatharan, CM Pondevida, ... Science advances 7 (42), eabj4077, 2021 | 8 | 2021 |
Deuterium tracing to interrogate compartment-specific NAD (P) H metabolism in cultured mammalian cells EW Lim, SJ Parker, CM Metallo Metabolic Flux Analysis in Eukaryotic Cells: Methods and Protocols, 51-71, 2020 | 6 | 2020 |
Serine and glycine are essential for human muscle progenitor cell population expansion BJ Gheller, JE Blum, EL Bender, ME Gheller, EW Lim, MK Handzlik, ... bioRxiv, 833798, 2019 | 2 | 2019 |
Supplemented Serum-Containing Culture Medium for Enhanced Arpe-19 Growth and Human Cytomegalovirus Vaccine Production S Christanti, EWY Lim, J Rodriguez, CL Daniels US Patent App. 17/420,177, 2022 | | 2022 |
Metabolic Compensation Associated with Progressive Mitochondrial Dysfunction E Lim, M Handzlik, C Metallo The FASEB Journal 35, 2021 | | 2021 |
Metabolic adaptation to progressive mitochondrial dysfunction in aging POLGD257A mice EW Lim, MK Handzlik, E Trefts, JM Gengatharan, RJ Shaw, CM Metallo bioRxiv, 2021.04. 29.441996, 2021 | | 2021 |
Reprogrammed TCA Cycle Maintains a Stem-Like Epitranscriptome and Therapeutic Persistence in Glioblastoma Stem Cells LJY Kim, EW Lim, JW Locasale, AE Sloan, CM Metallo, JN Rich JOURNAL OF NEUROSURGERY 132 (4), 123-123, 2020 | | 2020 |