Kristen E. Pauken
Kristen E. Pauken
Harvard Medical School
Verified email at hms.harvard.edu
Title
Cited by
Cited by
Year
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
C Twyman-Saint Victor, AJ Rech, A Maity, R Rengan, KE Pauken, ...
Nature 520 (7547), 373-377, 2015
15342015
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
AC Huang, MA Postow, RJ Orlowski, R Mick, B Bengsch, S Manne, W Xu, ...
Nature 545 (7652), 60-65, 2017
7602017
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
BT Fife, KE Pauken, TN Eagar, T Obu, J Wu, Q Tang, M Azuma, ...
Nature immunology 10 (11), 1185-1192, 2009
6682009
Overcoming T cell exhaustion in infection and cancer
KE Pauken, EJ Wherry
Trends in immunology 36 (4), 265-276, 2015
6582015
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
KE Pauken, MA Sammons, PM Odorizzi, S Manne, J Godec, O Khan, ...
Science 354 (6316), 1160-1165, 2016
5552016
The diverse functions of the PD1 inhibitory pathway
AH Sharpe, KE Pauken
Nature Reviews Immunology 18 (3), 153, 2018
5352018
Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
JL Benci, B Xu, Y Qiu, TJ Wu, H Dada, C Twyman-Saint Victor, L Cucolo, ...
Cell 167 (6), 1540-1554. e12, 2016
4982016
Resident memory CD8 T cells trigger protective innate and adaptive immune responses
JM Schenkel, KA Fraser, LK Beura, KE Pauken, V Vezys, D Masopust
Science 346 (6205), 98-101, 2014
4482014
Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8+ T cell exhaustion
B Bengsch, AL Johnson, M Kurachi, PM Odorizzi, KE Pauken, J Attanasio, ...
Immunity 45 (2), 358-373, 2016
3272016
The role of the PD‐1 pathway in autoimmunity and peripheral tolerance
BT Fife, KE Pauken
Annals of the New York Academy of Sciences 1217 (1), 45-59, 2011
3182011
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
PM Odorizzi, KE Pauken, MA Paley, A Sharpe, EJ Wherry
Journal of Experimental Medicine 212 (7), 1125-1137, 2015
2632015
CD39 expression identifies terminally exhausted CD8+ T cells
PK Gupta, J Godec, D Wolski, E Adland, K Yates, KE Pauken, C Cosgrove, ...
PLoS Pathog 11 (10), e1005177, 2015
1832015
CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors
LA Kalekar, SE Schmiel, SL Nandiwada, WY Lam, LO Barsness, N Zhang, ...
Nature immunology 17 (3), 304-314, 2016
1492016
IL-15–independent maintenance of tissue-resident and boosted effector memory CD8 T cells
JM Schenkel, KA Fraser, KA Casey, LK Beura, KE Pauken, V Vezys, ...
The Journal of Immunology 196 (9), 3920-3926, 2016
992016
TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit
KE Pauken, EJ Wherry
Cancer cell 26 (6), 785-787, 2014
692014
Adverse events following cancer immunotherapy: obstacles and opportunities
KE Pauken, M Dougan, NR Rose, AH Lichtman, AH Sharpe
Trends in immunology 40 (6), 511-523, 2019
632019
SnapShot: T cell exhaustion
KE Pauken, EJ Wherry
Cell 163 (4), 1038-1038. e1, 2015
632015
PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes
KE Pauken, MK Jenkins, M Azuma, BT Fife
Diabetes 62 (8), 2859-2869, 2013
582013
Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice
KE Pauken, JL Linehan, JA Spanier, NL Sahli, LA Kalekar, BA Binstadt, ...
The Journal of Immunology 191 (10), 4913-4917, 2013
452013
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes
KC Osum, AL Burrack, T Martinov, NL Sahli, JS Mitchell, CG Tucker, ...
Scientific reports 8 (1), 1-12, 2018
412018
The system can't perform the operation now. Try again later.
Articles 1–20