Kristen E. Pauken
Kristen E. Pauken
Harvard Medical School
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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
C Twyman-Saint Victor, AJ Rech, A Maity, R Rengan, KE Pauken, ...
Nature 520 (7547), 373-377, 2015
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
BT Fife, KE Pauken, TN Eagar, T Obu, J Wu, Q Tang, M Azuma, ...
Nature immunology 10 (11), 1185-1192, 2009
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
AC Huang, MA Postow, RJ Orlowski, R Mick, B Bengsch, S Manne, W Xu, ...
Nature 545 (7652), 60-65, 2017
Overcoming T cell exhaustion in infection and cancer
KE Pauken, EJ Wherry
Trends in immunology 36 (4), 265-276, 2015
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
KE Pauken, MA Sammons, PM Odorizzi, S Manne, J Godec, O Khan, ...
Science 354 (6316), 1160-1165, 2016
Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
JL Benci, B Xu, Y Qiu, TJ Wu, H Dada, C Twyman-Saint Victor, L Cucolo, ...
Cell 167 (6), 1540-1554. e12, 2016
Resident memory CD8 T cells trigger protective innate and adaptive immune responses
JM Schenkel, KA Fraser, LK Beura, KE Pauken, V Vezys, D Masopust
Science 346 (6205), 98-101, 2014
The diverse functions of the PD1 inhibitory pathway
AH Sharpe, KE Pauken
Nature Reviews Immunology 18 (3), 153, 2018
The role of the PD‐1 pathway in autoimmunity and peripheral tolerance
BT Fife, KE Pauken
Annals of the New York Academy of Sciences 1217 (1), 45-59, 2011
Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8+ T cell exhaustion
B Bengsch, AL Johnson, M Kurachi, PM Odorizzi, KE Pauken, J Attanasio, ...
Immunity 45 (2), 358-373, 2016
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
PM Odorizzi, KE Pauken, MA Paley, A Sharpe, EJ Wherry
Journal of Experimental Medicine 212 (7), 1125-1137, 2015
CD39 expression identifies terminally exhausted CD8+ T cells
PK Gupta, J Godec, D Wolski, E Adland, K Yates, KE Pauken, C Cosgrove, ...
PLoS Pathog 11 (10), e1005177, 2015
CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors
LA Kalekar, SE Schmiel, SL Nandiwada, WY Lam, LO Barsness, N Zhang, ...
Nature immunology 17 (3), 304-314, 2016
IL-15–independent maintenance of tissue-resident and boosted effector memory CD8 T cells
JM Schenkel, KA Fraser, KA Casey, LK Beura, KE Pauken, V Vezys, ...
The Journal of Immunology 196 (9), 3920-3926, 2016
TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit
KE Pauken, EJ Wherry
Cancer cell 26 (6), 785-787, 2014
PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes
KE Pauken, MK Jenkins, M Azuma, BT Fife
Diabetes 62 (8), 2859-2869, 2013
SnapShot: T cell exhaustion
KE Pauken, EJ Wherry
Cell 163 (4), 1038-1038. e1, 2015
Adverse events following cancer immunotherapy: obstacles and opportunities
KE Pauken, M Dougan, NR Rose, AH Lichtman, AH Sharpe
Trends in immunology 40 (6), 511-523, 2019
Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice
KE Pauken, JL Linehan, JA Spanier, NL Sahli, LA Kalekar, BA Binstadt, ...
The Journal of Immunology 191 (10), 4913-4917, 2013
Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade
KE Pauken, CE Nelson, T Martinov, JA Spanier, JR Heffernan, NL Sahli, ...
The Journal of Immunology 194 (8), 3551-3555, 2015
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