Kristen E. Pauken
Kristen E. Pauken
Harvard Medical School
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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
C Twyman-Saint Victor, AJ Rech, A Maity, R Rengan, KE Pauken, ...
Nature 520 (7547), 373-377, 2015
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
AC Huang, MA Postow, RJ Orlowski, R Mick, B Bengsch, S Manne, W Xu, ...
Nature 545 (7652), 60-65, 2017
Overcoming T cell exhaustion in infection and cancer
KE Pauken, EJ Wherry
Trends in immunology 36 (4), 265-276, 2015
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
BT Fife, KE Pauken, TN Eagar, T Obu, J Wu, Q Tang, M Azuma, ...
Nature immunology 10 (11), 1185-1192, 2009
The diverse functions of the PD1 inhibitory pathway
AH Sharpe, KE Pauken
Nature Reviews Immunology 18 (3), 153-167, 2018
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
KE Pauken, MA Sammons, PM Odorizzi, S Manne, J Godec, O Khan, ...
Science 354 (6316), 1160-1165, 2016
Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
JL Benci, B Xu, Y Qiu, TJ Wu, H Dada, C Twyman-Saint Victor, L Cucolo, ...
Cell 167 (6), 1540-1554. e12, 2016
Resident memory CD8 T cells trigger protective innate and adaptive immune responses
JM Schenkel, KA Fraser, LK Beura, KE Pauken, V Vezys, D Masopust
Science 346 (6205), 98-101, 2014
Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8+ T cell exhaustion
B Bengsch, AL Johnson, M Kurachi, PM Odorizzi, KE Pauken, J Attanasio, ...
Immunity 45 (2), 358-373, 2016
The role of the PD‐1 pathway in autoimmunity and peripheral tolerance
BT Fife, KE Pauken
Annals of the New York Academy of Sciences 1217 (1), 45-59, 2011
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
PM Odorizzi, KE Pauken, MA Paley, A Sharpe, EJ Wherry
Journal of Experimental Medicine 212 (7), 1125-1137, 2015
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
PK Gupta, J Godec, D Wolski, E Adland, K Yates, KE Pauken, C Cosgrove, ...
PLoS pathogens 11 (10), e1005177, 2015
CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors
LA Kalekar, SE Schmiel, SL Nandiwada, WY Lam, LO Barsness, N Zhang, ...
Nature immunology 17 (3), 304-314, 2016
IL-15–independent maintenance of tissue-resident and boosted effector memory CD8 T cells
JM Schenkel, KA Fraser, KA Casey, LK Beura, KE Pauken, V Vezys, ...
The Journal of Immunology 196 (9), 3920-3926, 2016
Adverse events following cancer immunotherapy: obstacles and opportunities
KE Pauken, M Dougan, NR Rose, AH Lichtman, AH Sharpe
Trends in immunology 40 (6), 511-523, 2019
TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit
KE Pauken, EJ Wherry
Cancer cell 26 (6), 785-787, 2014
SnapShot: T cell exhaustion
KE Pauken, EJ Wherry
Cell 163 (4), 1038-1038. e1, 2015
PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes
KE Pauken, MK Jenkins, M Azuma, BT Fife
Diabetes 62 (8), 2859-2869, 2013
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes
KC Osum, AL Burrack, T Martinov, NL Sahli, JS Mitchell, CG Tucker, ...
Scientific reports 8 (1), 1-12, 2018
Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade
KE Pauken, CE Nelson, T Martinov, JA Spanier, JR Heffernan, NL Sahli, ...
The Journal of Immunology 194 (8), 3551-3555, 2015
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