|How similar are similarity searching methods? A principal component analysis of molecular descriptor space|
A Bender, JL Jenkins, J Scheiber, SCK Sukuru, M Glick, JW Davies
Journal of chemical information and modeling 49 (1), 108-119, 2009
|Mapping adverse drug reactions in chemical space|
J Scheiber, JL Jenkins, SCK Sukuru, A Bender, D Mikhailov, M Milik, ...
Journal of medicinal chemistry 52 (9), 3103-3107, 2009
|Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis|
J Scheiber, B Chen, M Milik, SCK Sukuru, A Bender, D Mikhailov, ...
Journal of chemical information and modeling 49 (2), 308-317, 2009
|PALI—a database of Phylogeny and ALIgnment of homologous protein structures|
S Balaji, S Sujatha, SSC Kumar, N Srinivasan
Nucleic Acids Research 29 (1), 61-65, 2001
|Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications|
A Maderna, M Doroski, C Subramanyam, A Porte, CA Leverett, ...
Journal of medicinal chemistry 57 (24), 10527-10543, 2014
|Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity|
SCK Sukuru, JL Jenkins, REJ Beckwith, J Scheiber, A Bender, ...
Journal of biomolecular screening 14 (6), 690-699, 2009
|Optimization of tubulysin antibody–drug conjugates: a case study in addressing ADC metabolism|
LN Tumey, CA Leverett, B Vetelino, F Li, B Rago, X Han, F Loganzo, ...
ACS medicinal chemistry letters 7 (11), 977-982, 2016
|Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change|
SCK Sukuru, T Crepin, Y Milev, LC Marsh, JB Hill, RJ Anderson, ...
Journal of computer-aided molecular design 20 (3), 159-178, 2006
|“Virtual fragment linking”: an approach to identify potent binders from low affinity fragment hits|
TJ Crisman, A Bender, M Milik, JL Jenkins, J Scheiber, SCK Sukuru, ...
Journal of medicinal chemistry 51 (8), 2481-2491, 2008
|The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering|
S Quiroz-Valenzuela, SCK Sukuru, RP Hausinger, LA Kuhn, WT Heller
Archives of biochemistry and biophysics 480 (1), 51-57, 2008
|Design, synthesis, and cytotoxic evaluation of novel tubulysin analogues as ADC payloads|
CA Leverett, SCK Sukuru, BC Vetelino, S Musto, K Parris, J Pandit, ...
ACS medicinal chemistry letters 7 (11), 999-1004, 2016
|New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation|
Z Chen, A Maderna, SCK Sukuru, M Wagenaar, CJ O’Donnell, MH Lam, ...
Bioorganic & medicinal chemistry letters 23 (24), 6688-6694, 2013
|A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space|
SCK Sukuru, F Nigsch, J Quancard, M Renatus, R Chopra, N Brooijmans, ...
Protein Science 19 (11), 2096-2109, 2010
|Discovery of new auristatins for the use on antibody drug conjugates for the treatment of cancer|
A Maderna, M Doroski, H Risley, A Porte, Z Chen, C Subramanyam, ...
Abstracts of Papers of the American Chemical Society 246, 2013
|The Structure of Urease Activation Complexes Examined by Flexibility Analysis, Mutagenesis, and Small-angle X-ray Scattering Approaches|
S Quiroz, SCK Sukuru, RP Hausinger, LA Kuhn, WT Heller
Archives of Biochemistry and Biophysics 480 (1), 51-57, 2008
|SPREAD—exploiting chemical features that cause differential activity behavior|
J Scheiber, JL Jenkins, A Bender, M Milik, D Mikhailov, SCK Sukuru, ...
Statistical Analysis and Data Mining: The ASA Data Science Journal 2 (2 …, 2009
|Tubulysin analogs and methods for their preparation|
C Subramanyam, LN Tumey, L Xie, C Leverett, BC Vetelino, SCK Sukuru, ...
US Patent 10,723,727, 2020
|Towards Addressing Informatics Challenges Presented by Antibody Drug Conjugates|
C Sukuru, T Zhang, L Tumey, E Muszynska, M Tran, F Loganzo
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015
|Benzosuberenes as cytotoxic tubulin binding agents|
Z Chen, A Maderna, C Sukuru, F Loganzo
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 244, 2012
|Structural and statistical investigation of the trimethoxy-phenyl moiety in potent compounds that modulate multiple target classes|
SCK Sukuru, JA Bikker, CJ O'Donnell
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 242, 2011