Chetan Sukuru
Chetan Sukuru
Director, Research Informatics, Tango
Verified email at tangotx.com - Homepage
Title
Cited by
Cited by
Year
How similar are similarity searching methods? A principal component analysis of molecular descriptor space
A Bender, JL Jenkins, J Scheiber, SCK Sukuru, M Glick, JW Davies
Journal of chemical information and modeling 49 (1), 108-119, 2009
2872009
Mapping adverse drug reactions in chemical space
J Scheiber, JL Jenkins, SCK Sukuru, A Bender, D Mikhailov, M Milik, ...
Journal of medicinal chemistry 52 (9), 3103-3107, 2009
1692009
Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis
J Scheiber, B Chen, M Milik, SCK Sukuru, A Bender, D Mikhailov, ...
Journal of chemical information and modeling 49 (2), 308-317, 2009
1692009
PALI—a database of Phylogeny and ALIgnment of homologous protein structures
S Balaji, S Sujatha, SSC Kumar, N Srinivasan
Nucleic Acids Research 29 (1), 61-65, 2001
1172001
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications
A Maderna, M Doroski, C Subramanyam, A Porte, CA Leverett, ...
Journal of medicinal chemistry 57 (24), 10527-10543, 2014
972014
Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity
SCK Sukuru, JL Jenkins, REJ Beckwith, J Scheiber, A Bender, ...
Journal of biomolecular screening 14 (6), 690-699, 2009
802009
Optimization of tubulysin antibody–drug conjugates: a case study in addressing ADC metabolism
LN Tumey, CA Leverett, B Vetelino, F Li, B Rago, X Han, F Loganzo, ...
ACS medicinal chemistry letters 7 (11), 977-982, 2016
502016
Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change
SCK Sukuru, T Crepin, Y Milev, LC Marsh, JB Hill, RJ Anderson, ...
Journal of computer-aided molecular design 20 (3), 159-178, 2006
482006
“Virtual fragment linking”: an approach to identify potent binders from low affinity fragment hits
TJ Crisman, A Bender, M Milik, JL Jenkins, J Scheiber, SCK Sukuru, ...
Journal of medicinal chemistry 51 (8), 2481-2491, 2008
422008
The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering
S Quiroz-Valenzuela, SCK Sukuru, RP Hausinger, LA Kuhn, WT Heller
Archives of biochemistry and biophysics 480 (1), 51-57, 2008
392008
Design, synthesis, and cytotoxic evaluation of novel tubulysin analogues as ADC payloads
CA Leverett, SCK Sukuru, BC Vetelino, S Musto, K Parris, J Pandit, ...
ACS medicinal chemistry letters 7 (11), 999-1004, 2016
242016
New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation
Z Chen, A Maderna, SCK Sukuru, M Wagenaar, CJ O’Donnell, MH Lam, ...
Bioorganic & medicinal chemistry letters 23 (24), 6688-6694, 2013
152013
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space
SCK Sukuru, F Nigsch, J Quancard, M Renatus, R Chopra, N Brooijmans, ...
Protein Science 19 (11), 2096-2109, 2010
92010
Discovery of new auristatins for the use on antibody drug conjugates for the treatment of cancer
A Maderna, M Doroski, H Risley, A Porte, Z Chen, C Subramanyam, ...
Abstracts of Papers of the American Chemical Society 246, 2013
22013
The Structure of Urease Activation Complexes Examined by Flexibility Analysis, Mutagenesis, and Small-angle X-ray Scattering Approaches
S Quiroz, SCK Sukuru, RP Hausinger, LA Kuhn, WT Heller
Archives of Biochemistry and Biophysics 480 (1), 51-57, 2008
22008
SPREAD—exploiting chemical features that cause differential activity behavior
J Scheiber, JL Jenkins, A Bender, M Milik, D Mikhailov, SCK Sukuru, ...
Statistical Analysis and Data Mining: The ASA Data Science Journal 2 (2 …, 2009
12009
Tubulysin analogs and methods for their preparation
C Subramanyam, LN Tumey, L Xie, C Leverett, BC Vetelino, SCK Sukuru, ...
US Patent 10,723,727, 2020
2020
Towards Addressing Informatics Challenges Presented by Antibody Drug Conjugates
C Sukuru, T Zhang, L Tumey, E Muszynska, M Tran, F Loganzo
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015
2015
Benzosuberenes as cytotoxic tubulin binding agents
Z Chen, A Maderna, C Sukuru, F Loganzo
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 244, 2012
2012
Structural and statistical investigation of the trimethoxy-phenyl moiety in potent compounds that modulate multiple target classes
SCK Sukuru, JA Bikker, CJ O'Donnell
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 242, 2011
2011
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Articles 1–20