| A computational framework to explore large-scale biosynthetic diversity JC Navarro-Muñoz, N Selem-Mojica, MW Mullowney, SA Kautsar, ... Nature chemical biology 16 (1), 60-68, 2020 | 544 | 2020 |
| An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis X Huang, Y Dong, EA Bey, JA Kilgore, JS Bair, LS Li, M Patel, ... Cancer research 72 (12), 3038-3047, 2012 | 155 | 2012 |
| A community resource for paired genomic and metabolomic data mining MA Schorn, S Verhoeven, L Ridder, F Huber, DD Acharya, AA Aksenov, ... Nature Chemical Biology 17 (4), 363-368, 2021 | 102 | 2021 |
| Deoxynyboquinones as NQO1-activated cancer therapeutics EI Parkinson, PJ Hergenrother Accounts of chemical research 48 (10), 2715-2723, 2015 | 92 | 2015 |
| Synthesis of (±)-actinophyllic acid and analogs: Applications of cascade reactions and diverted total synthesis BA Granger, IT Jewett, JD Butler, B Hua, CE Knezevic, EI Parkinson, ... Journal of the American Chemical Society 135 (35), 12984-12986, 2013 | 77 | 2013 |
| Efficient NQO1 substrates are potent and selective anticancer agents EI Parkinson, JS Bair, M Cismesia, PJ Hergenrother ACS chemical biology 8 (10), 2173-2183, 2013 | 72 | 2013 |
| A computational framework for systematic exploration of biosynthetic diversity from large-scale genomic data JC Navarro-Muñoz, N Selem-Mojica, MW Mullowney, S Kautsar, JH Tryon, ... Biorxiv, 445270, 2018 | 53 | 2018 |
| Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics EI Parkinson, JH Tryon, AW Goering, KS Ju, RA McClure, JD Kemball, ... ACS chemical biology 13 (4), 1029-1037, 2018 | 43 | 2018 |
| Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria EI Parkinson, JS Bair, BA Nakamura, HY Lee, HI Kuttab, EH Southgate, ... Nature communications 6 (1), 6947, 2015 | 43 | 2015 |
| Fosmidomycin biosynthesis diverges from related phosphonate natural products EI Parkinson, A Erb, AC Eliot, KS Ju, WW Metcalf Nature chemical biology 15 (11), 1049-1056, 2019 | 24 | 2019 |
| Reactive oxygen species synergize to potently and selectively induce cancer cell death HY Lee, EI Parkinson, C Granchi, I Paterni, D Panigrahy, P Seth, ... ACS chemical biology 12 (5), 1416-1424, 2017 | 22 | 2017 |
| Runaway ROS as a selective anticancer strategy EI Parkinson, PJ Hergenrother ChemMedChem 6 (11), 1957-1959, 2011 | 21 | 2011 |
| Brønsted Acid Catalyzed C3-Alkylation of 2-Indolylmethanols with Azlactones via an Umpolung Strategy Y Shen, ZQ Zhu, JX Liu, L Yu, BX Du, GJ Mei, F Shi Synthesis 49 (17), 4025-4034, 2017 | 16 | 2017 |
| Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the … AP Lundberg, JM Francis, M Pajak, EI Parkinson, KL Wycislo, TJ Rosol, ... Investigational new drugs 35, 134-144, 2017 | 11 | 2017 |
| Synthetic natural product inspired cyclic peptides MA Hostetler, C Smith, S Nelson, Z Budimir, R Modi, I Woolsey, A Frerk, ... ACS Chemical Biology 16 (11), 2604-2611, 2021 | 9 | 2021 |
| An Unusual Oxidative Rearrangement Catalyzed by a Divergent Member of the 2‐Oxoglutarate‐Dependent Dioxygenase Superfamily during Biosynthesis of Dehydrofosmidomycin EI Parkinson, HG Lakkis, AA Alwali, MEM Metcalf, R Modi, WW Metcalf Angewandte Chemie International Edition 61 (30), e202206173, 2022 | 6 | 2022 |
| Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy AP Lundberg, MW Boudreau, KA Selting, LE Chatkewitz, J Samuelson, ... Neoplasia 23 (8), 811-822, 2021 | 5 | 2021 |
| Deoxynyboquinones as NQO1-targeted anticancer compounds and deoxynybomycins as potent and selective antibiotics EI Parkinson University of Illinois at Urbana-Champaign, 2015 | 4 | 2015 |
| Synthesis of gamma-butyrolactone hormones enables understanding of natural product induction LE Wilbanks, HE Hennigan, CD Martinez-Brokaw, H Lakkis, S Thormann, ... ACS Chemical Biology 18 (7), 1624-1631, 2023 | 3 | 2023 |
| Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase ZL Budimir, RS Patel, A Eggly, CN Evans, HM Rondon-Cordero, ... Nature Chemical Biology 20 (1), 120-128, 2024 | 2 | 2024 |
