|Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration|
CA Lindemans, M Calafiore, AM Mertelsmann, MH O’connor, JA Dudakov, ...
Nature 528 (7583), 560-564, 2015
|Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH|
J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ...
Science 350 (6266), 1391-1396, 2015
|Inducible in vivo genome editing with CRISPR-Cas9|
LE Dow, J Fisher, KP O'rourke, A Muley, ER Kastenhuber, G Livshits, ...
Nature biotechnology 33 (4), 390-394, 2015
|Transcriptional plasticity promotes primary and acquired resistance to BET inhibition|
P Rathert, M Roth, T Neumann, F Muerdter, JS Roe, M Muhar, S Deswal, ...
Nature 525 (7570), 543-547, 2015
|Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer|
LE Dow, KP O’Rourke, J Simon, DF Tschaharganeh, JH van Es, ...
Cell 161 (7), 1539-1552, 2015
|A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation|
MJ Ludford-Menting, J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, ...
Immunity 22 (6), 737-748, 2005
|A rapid and scalable system for studying gene function in mice using conditional RNA interference|
PK Premsrirut, LE Dow, SY Kim, M Camiolo, CD Malone, C Miething, ...
Cell 145 (1), 145-158, 2011
|Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi|
J Zuber, K McJunkin, C Fellmann, LE Dow, MJ Taylor, GJ Hannon, ...
Nature biotechnology 29 (1), 79-83, 2011
|The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge|
LE Dow, JS Kauffman, J Caddy, AS Peterson, SM Jane, SM Russell, ...
Oncogene 26 (16), 2272-2282, 2007
|Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling|
LE Dow, IA Elsum, CL King, KM Kinross, HE Richardson, PO Humbert
Oncogene 27 (46), 5988-6001, 2008
|The Scribble and Par complexes in polarity and migration: friends or foes?|
PO Humbert, LE Dow, SM Russell
Trends in cell biology 16 (12), 622-630, 2006
|SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia|
HB Pearson, PA Perez-Mancera, LE Dow, A Ryan, P Tennstedt, D Bogani, ...
The Journal of clinical investigation 121 (11), 4257-4267, 2011
|p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer|
DF Tschaharganeh, W Xue, DF Calvisi, M Evert, TV Michurina, LE Dow, ...
Cell 158 (3), 579-592, 2014
|hScrib is a functional homologue of the Drosophila tumour suppressor Scribble|
LE Dow, AM Brumby, R Muratore, ML Coombe, KA Sedelies, JA Trapani, ...
Oncogene 22 (58), 9225-9230, 2003
|A pipeline for the generation of shRNA transgenic mice|
LE Dow, PK Premsrirut, J Zuber, C Fellmann, K McJunkin, C Miething, ...
Nature protocols 7 (2), 374, 2012
|Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis|
LE Dow, PO Humbert
International review of cytology 262, 253-302, 2007
|Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition|
JE Bolden, N Tasdemir, LE Dow, JH van Es, JE Wilkinson, Z Zhao, ...
Cell reports 8 (6), 1919-1929, 2014
|Optimized base editors enable efficient editing in cells, organoids and mice|
MP Zafra, EM Schatoff, A Katti, M Foronda, M Breinig, AY Schweitzer, ...
Nature biotechnology 36 (9), 888-893, 2018
|Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer|
KP O'Rourke, E Loizou, G Livshits, EM Schatoff, T Baslan, E Manchado, ...
Nature biotechnology 35 (6), 577-582, 2017
|Modeling disease in vivo with CRISPR/Cas9|
Trends in molecular medicine 21 (10), 609-621, 2015