Lukas Dow
Lukas Dow
Weill Cornell Medicine
Verified email at med.cornell.edu
TitleCited byYear
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration
CA Lindemans, M Calafiore, AM Mertelsmann, MH O’connor, JA Dudakov, ...
Nature 528 (7583), 560, 2015
3612015
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ...
Science 350 (6266), 1391-1396, 2015
3382015
Inducible in vivo genome editing with CRISPR-Cas9
LE Dow, J Fisher, KP O'rourke, A Muley, ER Kastenhuber, G Livshits, ...
Nature biotechnology 33 (4), 390, 2015
3052015
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation
MJ Ludford-Menting, J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, ...
Immunity 22 (6), 737-748, 2005
2542005
A rapid and scalable system for studying gene function in mice using conditional RNA interference
PK Premsrirut, LE Dow, SY Kim, M Camiolo, CD Malone, C Miething, ...
Cell 145 (1), 145-158, 2011
2472011
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
P Rathert, M Roth, T Neumann, F Muerdter, JS Roe, M Muhar, S Deswal, ...
Nature 525 (7570), 543, 2015
2342015
Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer
LE Dow, KP O’Rourke, J Simon, DF Tschaharganeh, JH van Es, ...
Cell 161 (7), 1539-1552, 2015
2332015
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
J Zuber, K McJunkin, C Fellmann, LE Dow, MJ Taylor, GJ Hannon, ...
Nature biotechnology 29 (1), 79, 2011
2022011
The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge
LE Dow, JS Kauffman, J Caddy, AS Peterson, SM Jane, SM Russell, ...
Oncogene 26 (16), 2272, 2007
1652007
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
HB Pearson, PA Perez-Mancera, LE Dow, A Ryan, P Tennstedt, D Bogani, ...
The Journal of clinical investigation 121 (11), 4257-4267, 2011
1502011
Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling
LE Dow, IA Elsum, CL King, KM Kinross, HE Richardson, PO Humbert
Oncogene 27 (46), 5988, 2008
1502008
The Scribble and Par complexes in polarity and migration: friends or foes?
PO Humbert, LE Dow, SM Russell
Trends in cell biology 16 (12), 622-630, 2006
1492006
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble
LE Dow, AM Brumby, R Muratore, ML Coombe, KA Sedelies, JA Trapani, ...
Oncogene 22 (58), 9225, 2003
1332003
Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis
LE Dow, PO Humbert
International review of cytology 262, 253-302, 2007
1262007
A pipeline for the generation of shRNA transgenic mice
LE Dow, PK Premsrirut, J Zuber, C Fellmann, K McJunkin, C Miething, ...
Nature protocols 7 (2), 374, 2012
1202012
p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer
DF Tschaharganeh, W Xue, DF Calvisi, M Evert, TV Michurina, LE Dow, ...
Cell 158 (3), 579-592, 2014
1072014
Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition
JE Bolden, N Tasdemir, LE Dow, JH van Es, JE Wilkinson, Z Zhao, ...
Cell reports 8 (6), 1919-1929, 2014
882014
Modeling disease in vivo with CRISPR/Cas9
LE Dow
Trends in molecular medicine 21 (10), 609-621, 2015
732015
Life in the fast lane: mammalian disease models in the genomics era
LE Dow, SW Lowe
Cell 148 (6), 1099-1109, 2012
642012
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer
KP O'Rourke, E Loizou, G Livshits, EM Schatoff, T Baslan, E Manchado, ...
Nature biotechnology 35 (6), 577, 2017
622017
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Articles 1–20