Tommy Alain
Tommy Alain
Children's Hospital of Eastern Ontario Research Institute and University of Ottawa
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Cited by
Cited by
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
RJO Dowling, I Topisirovic, T Alain, M Bidinosti, BD Fonseca, ...
Science 328 (5982), 1172-1176, 2010
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation
M Morita, SP Gravel, V Chenard, K Sikström, L Zheng, T Alain, V Gandin, ...
Cell metabolism 18 (5), 698-711, 2013
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
D Olagnier, E Farahani, J Thyrsted, J Blay-Cadanet, A Herengt, M Idorn, ...
Nature communications 11 (1), 4938, 2020
Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence
PM D'Aoust, E Mercier, D Montpetit, JJ Jia, I Alexandrov, N Neault, ...
Water research 188, 116560, 2021
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
N Robichaud, SV del Rincon, B Huor, T Alain, LA Petruccelli, J Hearnden, ...
Oncogene 34 (16), 2032-2042, 2015
La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1)
BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ...
Journal of Biological Chemistry 290 (26), 15996-16020, 2015
Oncolytic reovirus against ovarian and colon cancer
K Hirasawa, SG Nishikawa, KL Norman, T Alain, A Kossakowska, ...
Cancer research 62 (6), 1696-1701, 2002
Distinct perturbation of the translatome by the antidiabetic drug metformin
O Larsson, M Morita, I Topisirovic, T Alain, MJ Blouin, M Pollak, ...
Proceedings of the National Academy of Sciences 109 (23), 8977-8982, 2012
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development
M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ...
Molecular and cellular biology, 2012
Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale
V Gandin, K Sikström, T Alain, M Morita, S McLaughlan, O Larsson, ...
JoVE (Journal of Visualized Experiments), e51455, 2014
La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs
RM Lahr, BD Fonseca, GE Ciotti, HA Al-Ashtal, JJ Jia, MR Niklaus, ...
Elife 6, e24146, 2017
Myxoma virus is a novel oncolytic virus with significant antitumor activity against experimental human gliomas
X Lun, W Yang, T Alain, ZQ Shi, H Muzik, JW Barrett, G McFadden, J Bell, ...
Cancer research 65 (21), 9982-9990, 2005
Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations
PM D'Aoust, TE Graber, E Mercier, D Montpetit, I Alexandrov, N Neault, ...
Science of The Total Environment 770, 145319, 2021
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies
T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ...
Cancer research 72 (24), 6468-6476, 2012
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling
BD Fonseca, GH Diering, MA Bidinosti, K Dalal, T Alain, AD Balgi, ...
Journal of Biological Chemistry 287 (21), 17530-17545, 2012
Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling
R Cao, B Robinson, H Xu, C Gkogkas, A Khoutorsky, T Alain, A Yanagiya, ...
Neuron 79 (4), 712-724, 2013
Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production
T Alain, XQ Lun, Y Martineau, P Sean, B Pulendran, E Petroulakis, ...
Proceedings of the National Academy of Sciences 107 (4), 1576-1581, 2010
Reovirus therapy of lymphoid malignancies
T Alain, K Hirasawa, KJ Pon, SG Nishikawa, SJ Urbanski, Y Auer, J Luider, ...
Blood, The Journal of the American Society of Hematology 100 (12), 4146-4153, 2002
p53-dependent translational control of senescence and transformation via 4E-BPs
E Petroulakis, A Parsyan, RJO Dowling, O LeBacquer, Y Martineau, ...
Cancer cell 16 (5), 439-446, 2009
Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E
B Herdy, M Jaramillo, YV Svitkin, AB Rosenfeld, M Kobayashi, D Walsh, ...
Nature immunology 13 (6), 543-550, 2012
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