Leonid S. Brown
Leonid S. Brown
Professor of Biophysics, University of Guelph
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Microbial and animal rhodopsins: structures, functions, and molecular mechanisms
OP Ernst, DT Lodowski, M Elstner, P Hegemann, LS Brown, H Kandori
Chemical reviews 114 (1), 126-163, 2014
Coherent control of retinal isomerization in bacteriorhodopsin
VI Prokhorenko, AM Nagy, SA Waschuk, LS Brown, RR Birge, RJD Miller
science 313 (5791), 1257-1261, 2006
Glutamic acid 204 is the terminal proton release group at the extracellular surface of bacteriorhodopsin
LS Brown, J Sasaki, H Kandori, A Maeda, R Needleman, JK Lanyi
Journal of Biological Chemistry 270 (45), 27122-27126, 1995
Conversion of Bacteriorhodopsin into a Chloride Ion Pump
J Sasaki, L Brown, YS Chon, A Maeda, R Needleman, JK Lanyi
Science 269, 73, 1995
Protein conformational changes in the bacteriorhodopsin photocycle
S Subramaniam, M Lindahl, P Bullough, AR Faruqi, J Tittor, D Oesterhelt, ...
Journal of molecular biology 287 (1), 145-161, 1999
Proton transfers in the photochemical reaction cycle of proteorhodopsin
AK Dioumaev, LS Brown, J Shih, EN Spudich, JL Spudich, JK Lanyi
Biochemistry 41 (17), 5348-5358, 2002
Proton binding within a membrane protein by a protonated water cluster
F Garczarek, LS Brown, JK Lanyi, K Gerwert
Proceedings of the National Academy of Sciences 102 (10), 3633-3638, 2005
Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein
S Wang, RA Munro, L Shi, I Kawamura, T Okitsu, A Wada, SY Kim, ...
Nature methods 10 (10), 1007-1012, 2013
Leptosphaeria rhodopsin: Bacteriorhodopsin-like proton pump from a eukaryote
SA Waschuk, AG Bezerra Jr, L Shi, LS Brown
Proceedings of the National Academy of Sciences 102 (19), 6879-6883, 2005
Existence of a proton transfer chain in bacteriorhodopsin: participation of Glu-194 in the release of protons to the extracellular surface
AK Dioumaev, HT Richter, LS Brown, M Tanio, S Tuzi, H Saitô, Y Kimura, ...
Biochemistry 37 (8), 2496-2506, 1998
A linkage of the p K a's of Asp-85 and Glu-204 forms part of the reprotonation switch of bacteriorhodopsin
HT Richter, LS Brown, R Needleman, JK Lanyi
Biochemistry 35 (13), 4054-4062, 1996
Crystallographic structures of the M and N intermediates of bacteriorhodopsin: assembly of a hydrogen-bonded chain of water molecules between Asp-96 and the retinal Schiff base
B Schobert, LS Brown, JK Lanyi
Journal of molecular biology 330 (3), 553-570, 2003
Three-dimensional solid-state NMR study of a seven-helical integral membrane proton pump—structural insights
L Shi, MAM Ahmed, W Zhang, G Whited, LS Brown, V Ladizhansky
Journal of molecular biology 386 (4), 1078-1093, 2009
Energy coupling in an ion pump: the reprotonation switch of bacteriorhodopsin
M Kataoka, H Kamikubo, F Tokunagga, LS Brown, Y Yamazaki, A Maeda, ...
Journal of molecular biology 243 (4), 621-638, 1994
Characterization of the photochemical reaction cycle of proteorhodopsin
G Váró, LS Brown, M Lakatos, JK Lanyi
Biophysical journal 84 (2), 1202-1207, 2003
Transient channel-opening in bacteriorhodopsin: an EPR study
TE Thorgeirsson, W Xiao, LS Brown, R Needleman, JK Lanyi, YK Shin
Journal of molecular biology 273 (5), 951-957, 1997
Conformation of a seven‐helical transmembrane photosensor in the lipid environment
L Shi, I Kawamura, KH Jung, LS Brown, V Ladizhansky
Angewandte Chemie 6 (123), 1338-1341, 2011
Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. I. The photochemical cycle
G Varo, LS Brown, J Sasaki, H Kandori, A Maeda, R Needleman, JK Lanyi
Biochemistry 34 (44), 14490-14499, 1995
Proton-detected solid-state NMR reveals intramembrane polar networks in a seven-helical transmembrane protein proteorhodopsin
ME Ward, L Shi, E Lake, S Krishnamurthy, H Hutchins, LS Brown, ...
Journal of the American Chemical Society 133 (43), 17434-17443, 2011
Solid-state NMR study of proteorhodopsin in the lipid environment: secondary structure and dynamics
L Shi, EMR Lake, MAM Ahmed, LS Brown, V Ladizhansky
Biochimica et Biophysica Acta (BBA)-Biomembranes 1788 (12), 2563-2574, 2009
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